Results 31 to 40 of about 328,885 (284)
VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma
BMC Gastroenterology, 2019 Background To investigate the von Willebrand factor to ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma (HCC) in cirrhosis.
Hiroaki Takaya +16 more
doaj +1 more source
Inflammation, von Willebrand factor, and ADAMTS13.
Blood, 2018 Increasing evidence indicates that inflammation can cause thrombosis by a von Willebrand factor (VWF)-mediated mechanism that includes endothelial activation, secretion of VWF, assembly of hyperadhesive VWF strings and fibers, cleavage by ADAMTS13, and ...
Junmei Chen, D. Chung
semanticscholar +1 more source
Shear-Induced Unfolding Activates von Willebrand Factor A2 Domain for Proteolysis [PDF]
J. Thromb. Haemost. 2009 (7), 2096-2105, 2009 To avoid pathological platelet aggregation by von Willebrand factor (VWF), VWF multimers are regulated in size and reactivity for adhesion by ADAMTS13-mediated proteolysis in a shear flow dependent manner. We examined if tensile stress in VWF under shear flow activates the VWF A2 domain for cleavage by ADAMTS13 using molecular dynamics simulations.
arxiv +1 more source
von Willebrand factor regulation of blood vessel formation.
Blood, 2018 Several important physiological processes, from permeability to inflammation to hemostasis, take place at the vessel wall and are regulated by endothelial cells (ECs). Thus, proteins that have been identified as regulators of one process are increasingly
A. Randi, Koval E Smith, G. Castaman
semanticscholar +1 more source
ON THE VERSATILITY OF VON WILLEBRAND FACTOR
Mediterranean Journal of Hematology and Infectious Diseases, 2013 Von Willebrand factor (VWF) is a large multimeric protein, the function of which has been demonstrated to be pivotal to the haemostatic system. Indeed, quantitative and/or qualitative abnormalities of VWF are associated with the bleeding disorder Von Willebrand disease (VWD).
Rauch, Antoine +5 more
openaire +4 more sources
Haematologica, 2010 Background Pregnancy in von Willebrand’s disease may carry a significant risk of bleeding. Information on changes in factor VIII and von Willebrand factor and pregnancy outcome in relation to von Willebrand factor gene mutations are very scanty.Design ...
Giancarlo Castaman +2 more
doaj +1 more source
The Pan African Medical Journal, 2021 INTRODUCTION: von Willebrand Disease (vWD) is the most prevalent bleeding disorder. Women are more likely to manifest abnormal bleeding symptoms due to physiologic events and menorrhagia is the most common presenting symptom.
Miyoba Melinda Munsanje +6 more
doaj +1 more source
Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura.
New England Journal of Medicine, 1998 BACKGROUND Thrombotic thrombocytopenic purpura is a potentially fatal disease characterized by widespread platelet thrombi in the microcirculation. In the normal circulation, von Willebrand factor is cleaved by a plasma protease.
H. Tsai, E. Lian
semanticscholar +1 more source
Haematologica, 2013 The carboxyl-terminal domains of von Willebrand factor, D4-CK, are cysteine-rich implying that they are structurally important. In this study we characterized the impact of five cysteine missense mutations residing in D4-CK domains on the conformation ...
Hamideh Yadegari +6 more
doaj +1 more source
Blood, 2019 D assemblies make up half of the von Willebrand factor (VWF), yet are of unknown structure. D1 and D2 in the prodomain and D'D3 in mature VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerization of D3 through disulfides ...
Xianchi Dong +7 more
semanticscholar +1 more source