Results 61 to 70 of about 328,885 (284)

Desmopressin testing in von Willebrand disease: Lowering the burden

Research and Practice in Thrombosis and Haemostasis, 2022
Background Individuals with von Willebrand disease (VWD) require desmopressin testing because of interindividual response differences. However, testing is burdensome, while not all patients may need extensive testing. Objectives To provide von Willebrand
Jessica M. Heijdra, Ferdows Atiq, Wala Al Arashi, Quincy Kieboom, Esmee Wuijster, Karina Meijer, Marieke J. H. A. Kruip, Frank W. G. Leebeek, Marjon H. Cnossen, in collaboration with the OPTI‐CLOT Study Group   +9 more
doaj   +1 more source

Phase 3 study of recombinant von Willebrand factor in patients with severe von Willebrand disease who are undergoing elective surgery

Journal of Thrombosis and Haemostasis, 2018
Essentials Recombinant von Willebrand factor (rVWF) is effective in von Willebrand disease (VWD). A phase 3 study of rVWF, with/without recombinant factor VIII (rFVIII) before surgery in VWD.
Flora Peyvandi, Flora Peyvandi, A. Mamaev, J.‐D. Wang, O. Stasyshyn, M. Timofeeva, Nicola Curry, Ana Rosa Cid, T. Yee, K. Kavakli, G. Castaman, A. Sytkowski   +11 more
semanticscholar   +1 more source

von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.

New England Journal of Medicine, 1998
BACKGROUND Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome are severe microvascular disorders of platelet clumping with similar signs and symptoms.
M. Furlan, R. Robles, M. Galbusera, G. Remuzzi, P. Kyrle, B. Brenner, M. Krause, I. Scharrer, V. Aumann, U. Mittler, M. Solenthaler, B. Lämmle   +11 more
semanticscholar   +1 more source

Cadmium regulates von Willebrand factor and occludin expression in glomerular endothelial cells of mice in a TNF-α-dependent manner

Renal Failure, 2019
Background: Cadmium (Cd) is an environmental pollutant that leads to nephrotoxicity. However, the mechanisms of Cd-induced glomerular injury have not been fully clarified. Von Willebrand factor (vWF) and occludin are important endothelial cell markers in
Zongguo Sun, Qi Xie, Jie Pan, Na Niu
doaj   +1 more source

Platelet interaction with von Willebrand factor is enhanced by shear-induced clustering of glycoprotein Ibα

Haematologica, 2013
Initial platelet arrest at the exposed arterial vessel wall is mediated through glycoprotein Ibα binding to the A1 domain of von Willebrand factor. This interaction occurs at sites of elevated shear force, and strengthens upon increasing hydrodynamic ...
Eelo Gitz, Charlotte D. Koopman, Alèkos Giannas, Cornelis A Koekman, Dave J. van den Heuvel, Hans Deckmyn, Jan-Willem N. Akkerman, Hans C. Gerritsen, Rolf T. Urbanus   +8 more
doaj   +1 more source

Evaluation of a semi‐automated von Willebrand factor multimer assay, the Hydragel 5 von Willebrand multimer, by two European Centers

Research and Practice in Thrombosis and Haemostasis, 2018
The phenotypic diagnosis of von Willebrand disease (VWD) is a multistep process with classification dependent on the quantification of von Willebrand factor (VWF) multimeric structure.
A. Bowyer, K. Goodfellow, H. Seidel, P. Westhofen, F. Stufano, A. Goodeve, S. Kitchen, M. Makris   +7 more
semanticscholar   +1 more source

Doença de von Willebrand e anestesia Enfermedad de von Willebrand y anestesia Von Willebrand's disease and anesthesia

Revista Brasileira de Anestesiologia, 2007
JUSTIFICATIVA E OBJETIVOS: A doença de von Willebrand ocorre devido à mutação no cromossomo 12 e é caracterizada por deficiência qualitativa ou quantitativa do fator de von Willebrand.
Fabiano Timbó Barbosa, Rafael Martins da Cunha, Luciano Timbó Barbosa   +2 more
doaj   +1 more source

Biochemistry and genetics of von Willebrand factor.

Annual Review of Biochemistry, 1998
Von Willebrand factor (VWF) is a blood glycoprotein that is required for normal hemostasis, and deficiency of VWF, or von Willebrand disease (VWD), is the most common inherited bleeding disorder.
Fred E. Cohen, S. B. Prusiner, D. G. Hardie, David Carling   +3 more
semanticscholar   +1 more source

Von Willebrand Factor Multimers during Transcatheter Aortic-Valve Replacement.

New England Journal of Medicine, 2016
BACKGROUND Postprocedural aortic regurgitation occurs in 10 to 20% of patients undergoing transcatheter aortic-valve replacement (TAVR) for aortic stenosis.
E. Van Belle, A. Rauch, F. Vincent, E. Robin, M. Kibler, J. Labreuche, E. Jeanpierre, M. Levade, C. Hurt, N. Rousse, J. Dally, N. Debry, J. Dallongeville, A. Vincentelli, C. Delhaye, J. Auffray, F. Juthier, G. Schurtz, G. Lemesle, T. Caspar, O. Morel, N. Dumonteil, A. Duhamel, C. Paris, Annabelle Dupont-Prado, P. Legendre, F. Mouquet, B. Marchant, Sylvie Hermoire, D. Corseaux, K. Moussa, A. Manchuelle, J. Bauchart, V. Loobuyck, C. Caron, C. Zawadzki, F. Leroy, J. Bodart, B. Staels, J. Goudemand, P. Lenting, S. Susen   +41 more
semanticscholar   +1 more source

Platelets and von Willebrand factor in atherogenesis.

Blood, 2017
The role of platelet adhesion, activation, and aggregation in acute atherothrombotic events such as myocardial infarction and stroke is well established.
Melinda D. Wu, Tamara M. Atkinson, J. Lindner   +2 more
semanticscholar   +1 more source