Results 61 to 70 of about 212,775 (379)

Flow-induced elongation of von Willebrand factor precedes tension-dependent activation

Nature Communications, 2017
Von Willebrand factor, an ultralarge concatemeric blood protein, must bind to platelet GPIbα during bleeding to mediate hemostasis, but not in the normal circulation to avoid thrombosis.
Hongxia Fu, Yan Jiang, Darren Yang, F. Scheiflinger, Wesley P. Wong, T. Springer   +5 more
semanticscholar   +1 more source

Factor fon Willebrand antigen in endothelium functional state assessment in patients with systemic lupus erythematosus

Научно-практическая ревматология, 2004
Objective. To determine the importance of von Willebrand factor antigen as marker of endotheliae damage at the patients with systemic lupus erythematosus (SLE). Material and methods. 30 women from authentic SLE by criteria ACR, in the age of 20-45 years,
M E Zapryagaeva, E S Mach, A A Baranov
doaj   +1 more source

Desmopressin testing in von Willebrand disease: Lowering the burden

Research and Practice in Thrombosis and Haemostasis, 2022
Background Individuals with von Willebrand disease (VWD) require desmopressin testing because of interindividual response differences. However, testing is burdensome, while not all patients may need extensive testing. Objectives To provide von Willebrand
Jessica M. Heijdra, Ferdows Atiq, Wala Al Arashi, Quincy Kieboom, Esmee Wuijster, Karina Meijer, Marieke J. H. A. Kruip, Frank W. G. Leebeek, Marjon H. Cnossen, in collaboration with the OPTI‐CLOT Study Group   +9 more
doaj   +1 more source

Acquired Von Willebrand Factor Deficiency at Patient-Prosthesis Mismatch after AVR Procedure—A Narrative Review

Medicina, 2023
Acquired von Willebrand factor deficiency has been described in patients with aortic valve stenosis due to high shear forces developed during passage through the narrowed valve orifice, which determines structural changes in this molecule.
Andrei Emanuel Grigorescu, Andrei Anghel, Darius Gheorghe Buriman, Horea Feier   +3 more
doaj   +1 more source

Enfermedad de von Willebrand, biología molecular y diagnóstico [PDF]

, 2015
ResumenAntecedentesLa enfermedad de von Willebrand es el trastorno hereditario más frecuente de las proteínas de la coagulación en los seres humanos. Existen 3 tipos: 1, 2A, 2B, 2N, 2M, y 3. Está asociada a mutaciones en el cromosoma 12, en la región p13.
Hernández-Zamora, Edgar, Quintana-González, Sandra, Reyes-Maldonado, Elba, Zavala-Hernández, Cesar   +3 more
core   +1 more source

[Cost-minimization analysis of replacement therapy in the treatment of von Willebrand disease]

Farmeconomia: Health Economics and Therapeutic Pathways, 2016
BACKGROUND: Replacement therapy with von Willebrand factor (VWF)/factor VIII (FVIII) concentrates represents an effective approach for patients with von Willebrand disease (VWD) who are unresponsive to desmopressin.
Giancarlo Castaman
doaj   +1 more source

von Willebrand factor variant p.Arg924Gln marks an allele associated with reduced von Willebrand factor and factor VIII levels [PDF]

, 2010
Background: von Willebrand factor (VWF) variant c.2771G>A; p.R924Q has been described as a benign polymorphism or a possible marker for a null allele and been associated with mild bleeding phenotypes.
Berber, Budde, Caron, Casais, Castaman, Cumming, Daly, Davies, Eikenboom, Eikenboom, Eikenboom, Goodeve, Green, Hilbert, James, Lester, Nichols, Orstavik, Souto, Tosetto   +19 more
core   +1 more source

Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the Endothelium

Advanced Healthcare Materials, EarlyView.
Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche, Ségolène Ladaigue, Giacomo Gropplero, Nicolas Zimmermann, Martin Nurmik, Irina Veith, Manh‐Louis Nguyen, Solenn Brosseau, Nicolas Poté, Pierre Mordant, Arnaud Roussel, Fathia Mami‐Chouaib, Fatima Mechta‐Grigoriou, Gérard Zalcman, Fabrice Soncin, Stéphanie Descroix, Maria Carla Parrini   +16 more
wiley   +1 more source

Successful Aortic Aneurysm Repair in a Woman with Severe von Willebrand (Type 3) Disease

Case Reports in Hematology, 2015
von Willebrand disease type 3 (VWD3) is a rare but the most severe form of von Willebrand disease; it is due to almost complete lack of von Willebrand factor activity (VWF:RCo).
Victoria Campbell, Kevin Marriott, Rex Stanbridge, Abdul Shlebak   +3 more
doaj   +1 more source

Phase 3 study of recombinant von Willebrand factor in patients with severe von Willebrand disease who are undergoing elective surgery

Journal of Thrombosis and Haemostasis, 2018
Essentials Recombinant von Willebrand factor (rVWF) is effective in von Willebrand disease (VWD). A phase 3 study of rVWF, with/without recombinant factor VIII (rFVIII) before surgery in VWD.
Flora Peyvandi, Flora Peyvandi, A. Mamaev, J.‐D. Wang, O. Stasyshyn, M. Timofeeva, Nicola Curry, Ana Rosa Cid, T. Yee, K. Kavakli, G. Castaman, A. Sytkowski   +11 more
semanticscholar   +1 more source