Results 61 to 70 of about 214,027 (378)

Acquired Von Willebrand Factor Deficiency at Patient-Prosthesis Mismatch after AVR Procedure—A Narrative Review

Medicina, 2023
Acquired von Willebrand factor deficiency has been described in patients with aortic valve stenosis due to high shear forces developed during passage through the narrowed valve orifice, which determines structural changes in this molecule.
Andrei Emanuel Grigorescu, Andrei Anghel, Darius Gheorghe Buriman, Horea Feier   +3 more
doaj   +1 more source

Phase 3 study of recombinant von Willebrand factor in patients with severe von Willebrand disease who are undergoing elective surgery

Journal of Thrombosis and Haemostasis, 2018
Essentials Recombinant von Willebrand factor (rVWF) is effective in von Willebrand disease (VWD). A phase 3 study of rVWF, with/without recombinant factor VIII (rFVIII) before surgery in VWD.
Flora Peyvandi, Flora Peyvandi, A. Mamaev, J.‐D. Wang, O. Stasyshyn, M. Timofeeva, Nicola Curry, Ana Rosa Cid, T. Yee, K. Kavakli, G. Castaman, A. Sytkowski   +11 more
semanticscholar   +1 more source

Successful Aortic Aneurysm Repair in a Woman with Severe von Willebrand (Type 3) Disease

Case Reports in Hematology, 2015
von Willebrand disease type 3 (VWD3) is a rare but the most severe form of von Willebrand disease; it is due to almost complete lack of von Willebrand factor activity (VWF:RCo).
Victoria Campbell, Kevin Marriott, Rex Stanbridge, Abdul Shlebak   +3 more
doaj   +1 more source

Az érfal trombogenitása és annak szabályozása = Vessel wall thrombogenicity and its regulation [PDF]

, 2008
Fiziológiás hemosztázis ill. artériás trombózis keletkezésekor a trombociták a gyorsan áramló vérből von Willebrand faktoron keresztül tapadnak ki az érfalban lévő kollagénhez. Az érfal mátrix komponenseit vizsgálva megállapítottuk, hogy a media rétegből
Gombás, Judit, Komorowicz, Erzsébet, Váradi, Balázs   +2 more
core  

Vorticity‐Facilitated Platelet Aggregation: a High Expansion‐Ratio Stenotic Microfluidic Platform Unravels the Role of Complex Flow Dynamics in Arterial Thrombosis

Advanced Healthcare Materials, EarlyView.
This study reveals how vorticity—a swirling flow pattern—enhances platelet aggregation and thrombus formation in high‐shear conditions. Using a custom microfluidic model, it is shows that vorticity promotes vWF–GPIbα interactions and calcium signaling, providing new insights into thrombosis mechanobiology and informing safer blood‐contacting medical ...
Jianfang Ren, Nurul Aisha Zainal Abidin, Allan Sun, Rui Gao, Yuxin Chen, Arian Nasser, Zihao Wang, Yunduo Charles Zhao, Alexander Dupuy, Anna Waterhouse, Qian Peter Su, Daniele Vigolo, Mike Chia Lun Wu, Lining Arnold Ju   +13 more
wiley   +1 more source

Platelet interaction with von Willebrand factor is enhanced by shear-induced clustering of glycoprotein Ibα

Haematologica, 2013
Initial platelet arrest at the exposed arterial vessel wall is mediated through glycoprotein Ibα binding to the A1 domain of von Willebrand factor. This interaction occurs at sites of elevated shear force, and strengthens upon increasing hydrodynamic ...
Eelo Gitz, Charlotte D. Koopman, Alèkos Giannas, Cornelis A Koekman, Dave J. van den Heuvel, Hans Deckmyn, Jan-Willem N. Akkerman, Hans C. Gerritsen, Rolf T. Urbanus   +8 more
doaj   +1 more source

Desmopressin testing in von Willebrand disease: Lowering the burden

Research and Practice in Thrombosis and Haemostasis, 2022
Background Individuals with von Willebrand disease (VWD) require desmopressin testing because of interindividual response differences. However, testing is burdensome, while not all patients may need extensive testing. Objectives To provide von Willebrand
Jessica M. Heijdra, Ferdows Atiq, Wala Al Arashi, Quincy Kieboom, Esmee Wuijster, Karina Meijer, Marieke J. H. A. Kruip, Frank W. G. Leebeek, Marjon H. Cnossen, in collaboration with the OPTI‐CLOT Study Group   +9 more
doaj   +1 more source

Clinically relevant differences between assays for von Willebrand factor activity

Journal of Thrombosis and Haemostasis, 2018
Essentials It is unclear whether there are differences between von Willebrand factor (VWF) activity assays. We compared the four most used VWF activity assays in 661 von Willebrand disease (VWD) patients.
J. Boender, J. Eikenboom, J. Bom, K. Meijer, J. D. Meris, K. Fijnvandraat, M. Cnossen, B. Gorkom, W. Heerde, E. Mauser-Bunschoten, M. Maat, F. Leebeek   +11 more
semanticscholar   +1 more source

Migraine and vascular disease biomarkers: A population-based case-control study. [PDF]

, 2018
Background The underpinnings of the migraine-stroke association remain uncertain, but endothelial activation is a potential mechanism. We evaluated the association of migraine and vascular disease biomarkers in a community-based population.
Ferrari, Michel D., Herial, Nabeel, Khubchandani, Jagdish, Koppen, Hille, Kruit, Mark C., Launer, Lenore J., Palm-Meinders, Inge H., Terwindt, Gisela M., Tietjen, Gretchen E., van Buchem, Mark A.   +9 more
core   +2 more sources

Novel Drug‐Testing Platform for Vascular Injury‐induced Intimal Hyperplasia Using a Microphysiological System

Advanced Healthcare Materials, EarlyView.
This study develops a 3D vascular injury model using a microphysiological system that mimics key features of intimal hyperplasia. Antiproliferative drugs reduced VSMC proliferation but worsened endothelialdenudation. A combination of diphenyleneiodonium and quercetin effectively reduced proliferation and migration of VSMC and inflammation while ...
Ungsig Nam, HyeMi Kim, Jeong Ah Kim, Ki‐Hwan Nam, Kye‐Sung Lee, Hwan Hur, Jessie S. Jeon, Ji Yong Bae   +7 more
wiley   +1 more source