Results 111 to 120 of about 47,572 (272)

Long‐term outcome after allogeneic stem cell transplantation for GATA2 deficiency: An analysis of 67 adults and children from France and Belgium

British Journal of Haematology, EarlyView.
The overall survival of patients receiving an allogeneic haematopoietic stem cell transplant (HSCT) for GATA2 deficiency was significantly better if they were transplanted recently, with a bone marrow or cord blood graft and if the transplant was performed before the onset of excess blast. Excess blast before HSCT was the only factor associated with an
Flore Sicre de Fontbrune, Florian Chevillon, Mony Fahd, Kristell Desseaux, Xavier Poiré, Edouard Forcade, Arthur Sterin, Bénédicte Neven, Virginie Gandemer, Sylvain Thepot, Alice Garnier, Bruno Lioure, Ambroise Marcais, Stephanie Nguyen‐Quoc, Suzanne Tavitian, Laure Vincent, Jean Donadieu, Matthieu Resche Riggon, Sylvie Chevret, Marlene Pasquet, Regis Peffault de Latour   +20 more
wiley   +1 more source

Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51) [PDF]

, 2015
Herein, we have investigated the amebicidal activities of the pharmaceutical triazole CYP51 inhibitors fluconazole, itraconazole, and voriconazole against Acanthamoeba castellanii and Acanthamoeba polyphaga and assess their potential as therapeutic ...
Andrew G. S. Warrilow, David C. Lamb, Diane E. Kelly, Josie E. Parker, Nicola J. Rolley, Stephen N. Smith, Steven L. Kelly, W. David Nes   +7 more
core   +1 more source

An Update on Voriconazole in Ophthalmology

Delhi Journal of Ophthalmology, 2016
Ocular mycosis is one of the leading causes of corneal blindness. The range of common antifungal agents available for ocular mycosis remains inadequate and is generally associated with poor clinical outcomes. Voriconazole is a newer generation triazole antifungal agent, only marketed in systemic formulation, with broad-spectrum activity and a high ...
Venkatachalam K, Heralgi Mm, Vokuda H, Badami A   +3 more
openaire   +4 more sources

A suspected case of autoinduction of voriconazole metabolism in a patient with cerebral aspergillosis

Drug, Healthcare and Patient Safety, 2017
Martin J Ferguson,1 Maria L Randles,2 Declan G de Freitas3 1Pharmacy Department, Beaumont Hospital, Beaumont, Dublin, 2Pharmacy Department, Wexford General Hospital, Wexford, 3Department of Transplantation, Urology and Nephrology, Beaumont Hospital ...
Ferguson MJ, Randles ML, de Freitas DG
doaj  

Characteristics of voriconazole-induced visual disturbances and hallucinations: case reports and literature review

Frontiers in Pharmacology
Voriconazole, a broad-spectrum antifungal agent, is considered the first-line treatment for invasive aspergillosis. In this article, we report three cases of patients who experienced visual disturbances and hallucinations following voriconazole therapy ...
Ya Liu, Ying Huang, Xiang Liu, Danxia Wang, Yixiang Hu   +4 more
doaj   +1 more source

The epidemiological landscape of bloodstream infections in children undergoing chemotherapy or haematopoietic cell transplantation: A retrospective study by Infectious Diseases Working Group of Italian Association of Pediatric Hematology and Oncology (AIEOP)

British Journal of Haematology, EarlyView.
Summary Understanding bloodstream infection (BSI) epidemiology is crucial for optimizing antibiotic therapy in paediatric haematology–oncology patients undergoing chemotherapy or haematopoietic cell transplantation (HCT). However, updated paediatric data remain scarce.
Francesco Baccelli, Francesca Compagno, Gloria Tridello, Francesco Delle Cave, Daniele Zama, Riccardo Masetti, Maria Grazia Petris, Lorenzo Chiusaroli, Manuela Spadea, Francesca Trevisan, Antonella Colombini, Samantha Conci, Cristina Meazza, Paola Muggeo, Maria Vittoria Micheletti, Alessia Pancaldi, Rosamaria Mura, Daniela Onofrillo, Raffaella De Santis, Milena La Spina, Elio Castagnola, Katia Perruccio, Angelica Barone, Nagua Giurici, Angelamaria Petrone, Federico Mercolini, Simona Rinieri, Simone Cesaro, Francesca Carraro7, Annalisa Tondo9, Laura Rachele Bettini10, Elena Pletto2, Olga Nigro11, Roberta Martino12, Eva Parolo13, Giovanni Palazzi12   +35 more
wiley   +1 more source

Has early mortality following single‐unit unrelated cord blood transplantation improved in recent years? A nationwide registry data analysis from 2003 to 2022 in Japan

British Journal of Haematology, EarlyView.
The 100‐day non‐relapse mortality after single‐unit cord blood transplantation significantly declined from 19.6% (2003–2007) to 9.5% (2018–2022), while the 3‐year overall survival improved from 38.8% to 54.4%. Haematopoietic recovery rates improved steadily, with neutrophil engraftment reaching 89.6% and platelet engraftment 78.0% in the most recent ...
Takaaki Konuma, Junya Kanda, Naoyuki Uchida, Masatsugu Tanaka, Fumihiko Kimura, Hideki Nakasone, Yasufumi Uehara, Masahito Tokunaga, Masako Toyosaki, Shigesaburo Miyakoshi, Noriko Doki, Kazuya Ishiwata, Hikaru Kobayashi, Yasushi Onishi, Yasuji Kozai, Koji Kato, Fumihiko Ishimaru, Takahiro Fukuda, Yoshiko Atsuta, Satoshi Takahashi   +19 more
wiley   +1 more source

Topiramate for the treatment of neonatal seizures and beyond

Epilepsia, EarlyView.
Abstract Acute symptomatic neonatal seizures are one of the most common neurological disorders in newborns admitted to neonatal intensive care units and require prompt treatment. Up to 50% of neonatal seizures are refractory to first‐line medications such as phenobarbital (PB), and another 30% fail second‐line therapy.
Wolfgang Löscher, Janet S. Soul
wiley   +1 more source

Identification and Characterization of Three Novel Biomarkers for Mixed/Cholestatic Drug‐Induced Liver Injury

Hepatology Research, EarlyView.
Three metabolites, pyroglutamylglycine (pyroGluGly), phenylalanine (Phe), and phenylalanyltryptophan (PheTrp), were identified as candidate DILI biomarkers. The serum concentrations of pyroGluGly, Phe, and PheTrp demonstrated a high differentiating ability in patients with mixed and cholestatic DILI compared with those in patients who recovered from ...
Kosuke Saito, Tatehiro Kagawa, Keiji Tsuji, Yuji Kumagai, Ken Sato, Shotaro Sakisaka, Naoya Sakamoto, Mitsuhiko Aiso, Shunji Hirose, Nami Mori, Toshio Uraoka, Kazuhide Takata, Koji Ogawa, Kazuhiko Mori, Motonobu Sato, Takayoshi Nishiya, Kazuhiko Takamatsu, Noriaki Arakawa, Takashi Izumi, Ruri Kikura‐Hanajiri, Yasuo Ohno, Yoshiro Saito, Hajime Takikawa   +22 more
wiley   +1 more source

Invasive pulmonary aspergillosis post extracorporeal membrane oxygenation support and literature review [PDF]

, 2014
The use of extracorporeal membrane oxygenation (ECMO) for reversible pulmonary failure in critically ill patients has increased over the last few decades.
Al-Shair, Armstrong-James, Aubron, Aubron, Bizzarro, Blot, Burket, Caillot, De Pauw, Elefanti, Estrada, Garcia, Hsu, Marasco, O’Neill, Patterson, Seyedmousavi, Upton, Walsh   +18 more
core   +3 more sources