Results 101 to 110 of about 34,473 (219)

Design, Synthesis, and Biological Evaluation of Benzimidazol‐2‐One Hybrids as Potential Anti‐Alzheimer's Disease Agents

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder for which single‐target therapies often provide insufficient benefit, motivating the development of multi‐target‐directed ligands (MTDLs). In this study, a novel series of benzimidazolone‐based hybrids incorporating piperazine, coumarin, and triazole moieties was designed,
Fatih Yılmaz, Emre Menteşe, Ozan Emre Eyüpoğlu, Bahittin Kahveci, Mustafa Emirik   +4 more
wiley   +1 more source

Risk factors for voriconazole-associated hepatotoxicity in patients with liver dysfunction: a retrospective nested case–control study

Frontiers in Pharmacology
IntroductionVoriconazole is widely used to prevent and treat invasive aspergillosis. However, its use is restricted by adverse effects, including acute liver injury (ALI).
Jing Ren, Xinfeng Cai, Wei Ge, Jinlin Guo, Shan Wang, Qinhui Wang, Linna Liu, Le Yang, Qi Yang   +8 more
doaj   +1 more source

Voriconazole Induced Bradycardia

, 2013
Voriconazole is a triazole antifungal drug that is used to treat invasive fungal infections, especially aspergillus. Here, we report two children who had severe bradycardia associated with voriconazole at a dose of 12 mg/kg per day.
Celkan, Tiraje, Uludag, Dilek, Eroglu, Ayse Guler, Tuysuz, Gulen, Ozdemir, Nihal   +4 more
core   +1 more source

Hypercalcemia in a Patient With Spinal Tuberculosis and Aspergillus Co‐Infection: A Case‐Report

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Background Tuberculosis (TB), one of the leading infectious causes of mortality worldwide, may disseminate hematogenously and result in extrapulmonary manifestations. Spinal tuberculosis (ST) is an uncommon but serious form of extrapulmonary TB.
Negin Parsa, Amirpasha Amlelshahbaz, Hamidreza Soltani   +2 more
wiley   +1 more source

A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles

, 2015
Hyewon Chung,1,* Howard Lee,1,2,* HyeKyung Han,1 Hyungmi An,1 Kyoung Soo Lim,1,3 YongJin Lee,4 Joo-Youn Cho,1 Seo Hyun Yoon,1 In-Jin Jang,1 Kyung-Sang Yu1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of ...
Jang IJ, Lim KS, Yoon SH, Cho JY, Yu KS, Han H, Lee H, An H, Lee YJ, Chung H   +9 more
core  

Suzetrigine Is Not Expected to Have Clinically Relevant DDIs with Apixaban and Rivaroxaban Based on PBPK Modeling

The Journal of Clinical Pharmacology, Volume 66, Issue 9, September 2026.
Abstract Suzetrigine (VX‐548) is a first‐in‐class, oral, non‐opioid, FDA‐approved analgesic for the treatment of moderate to severe acute pain. Based on Phase 1 clinical drug–drug interaction (DDI) studies, suzetrigine is a weak‐to‐moderate cytochrome P450 3A (CYP3A) inducer and thus has the potential to decrease exposure and impact efficacy of CYP3A ...
Guanyu Wang, Elizabeth Lakota, Bo Feng, Licong Jiang, Guiqing Liang, Brian Hare   +5 more
wiley   +1 more source

Prognosis of Patients Infected With Talaromyces marneffei Across Various Risk Factors

Journal of General and Family Medicine, Volume 27, Issue 5, September 2026.
ABSTRACT Background Talaromyces marneffei (TM) is an opportunistic infectious fungus, and more patients in HIV‐negative populations are infected with TM. Methods We reviewed the adult patients with TM infections (TMIs) between November 1, 2020 and April 30, 2025.
JiaXin Wang, YaoMin Wang, RenDing Wang
wiley   +1 more source

INTERNATIONAL MULTICENTER EXPERIENCE IN THE TREATMENT OF INVASIVE ASPERGILLOSIS IN IMMUNOCOMPROMISED CANCER PATIENTS

Mediterranean Journal of Hematology and Infectious Diseases, 2019
BACKGROUND: Invasive aspergillosis (IA) is a life-threatening infection in immunocompromised patients. In this study, we compared the efficacy of voriconazole containing regimen vs non-voriconazole containing regimen in patients with IA.
R. Hachem, Marjorie Batista, Souha S Kanj, Saaed El Zein, Sara Haddad, Ying Jiang, Nobuyoshi Mori, Rocha Vanderson, Anne-Marie Chaftari, Issam I Raad   +9 more
doaj   +1 more source

Clinical Value of Metagenomic Next‐Generation Sequencing Versus Conventional Methods in Diagnosing Cryptococcal Infection After Kidney Transplantation

Organ Medicine, Volume 3, Issue 3, Page 130-138, September 2026.
This retrospective study evaluated metagenomic next‑generation sequencing (mNGS) against conventional methods (India ink, culture, antigen) for diagnosing cryptococcal infection in 16 kidney transplant recipients. mNGS showed a significantly higher positivity rate (93.8% vs 62.5%, p = 0.031) and shorter turnaround time (24 vs. 120 h, p < 0.001).
Luhao Liu, Rongxin Chen, Haonan Lin, Yuhe Guo, Guanghui Li, Jiali Fang, Zheng Chen   +6 more
wiley   +1 more source

A Practical Alternative to Refine the Estimate of fmCYP3A4 and Evaluate Drug–Drug Interaction Potential for Ziftomenib Using PBPK Modeling to Inform Labeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Accurate physiologically based pharmacokinetic (PBPK) simulation of drug–drug interaction (DDI) potential requires estimation of the relative contribution of the impacted pathway. While fraction metabolized by CYP enzymes is usually estimated using dedicated clinical DDI studies with strong CYP inhibitors, this approach might not be available ...
Ian E. Templeton, Chara Litou, Hannah M. Jones, Julie Mackey Ahsan, Marilyn Tabachri, Mollie Leoni, Amitava Mitra   +6 more
wiley   +1 more source