Results 91 to 100 of about 32,129 (220)

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Drug Critical Limits for Urgent Physician Notification

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 178-192, July 2026.
Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang, Yasmeen Ibrahim, Kyle Cheng, Gerald J. Kost   +3 more
wiley   +1 more source

Antifungal Potential of Cumin Spice Seeds, Cuminum cyminum, Against Aspergillus fumigatus: Mechanistic Insights Into Ergosterol, Melanin, and Biofilm Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Antifungal effects and underlying mechanism of the action of the supercritical fluid extracted from the cumin (Cuminum cyminum) seeds and its volatile phyto‐constituents against pathogenic Aspergillus fumigatus. ABSTRACT Spices are aromatic culinary ingredients used worldwide for enhancing food flavors, folklore therapy, and their antiseptic ...
Acharya Balkrishna, Lovely Gupta, Rani Singh, Yash Varshney, Rishabh Dev, Pardeep Nain, Savita Lochab, Anurag Varshney   +7 more
wiley   +1 more source

Invasive sphenoidal aspergillosis: successful treatment with sphenoidotomy and voriconazole

, 2007
Treatment of invasive sphenoidal aspergillosis is surgical, followed by antifungal therapy, mostly amphotericin B. To optimize the adjuvant antifungal treatment, which is often limited by severe side effects, the new triazole antifungal agent ...
Baumann, Ariane, Zimmerli, Stefan, Caversaccio, Marco, Hausler, Rudolf   +3 more
core   +1 more source

Enhancing voriconazole therapy in liver dysfunction: exploring administration schemes and predictive factors for trough concentration and efficacy

Frontiers in Pharmacology
Introduction: The application of voriconazole in patients with liver dysfunction lacks pharmacokinetic data. In previous study, we proposed to develop voriconazole dosing regimens for these patients according to their total bilirubin, but the regimens ...
Yichang Zhao, Yichang Zhao, Huaiyuan Liu, Huaiyuan Liu, Chenlin Xiao, Chenlin Xiao, Jingjing Hou, Jingjing Hou, Bikui Zhang, Bikui Zhang, Jiakai Li, Jiakai Li, Min Zhang, Yongfang Jiang, Indy Sandaradura, Indy Sandaradura, Xuansheng Ding, Miao Yan, Miao Yan   +18 more
doaj   +1 more source

Consistency and clarity of pharmacogenomic guidance in UK medicine patient information leaflets: A cross‐sectional analysis

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1934-1939, June 2026.
Pharmacogenomic (PGx) information has the potential to support the safe and effective use of medicines, yet there is uncertainty about how this information can be best communicated to patients. Summaries of product characteristics (SmPCs) and patient information leaflets (PILs) for all UK‐approved medicines with strong evidence supporting a PGx ...
Parth Narlawar, Chloe Ratcliffe, Videha Sharma, William G. Newman, Munir Pirmohamed, John McDermott   +5 more
wiley   +1 more source

Successful treatment of Chrysosporium keratitis with voriconazole

, 2017
Onsiri Thanathanee, Chavakij Bhoomibunchoo, Orapin Anutarapongpan, Olan Suwan-apichon, Yosanan Yospaiboon KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Objective: To report a ...
Thanathanee O, Suwan-apichon O, Anutarapongpan O, Yospaiboon Y, Bhoomibunchoo C   +4 more
core  

Voriconazole successfully treats chytridiomycosis in frogs

Chytridiomycosis is a devastating disease and is a key cause of amphibian population declines around the world. Despite active research on this amphibian disease system for over 2 decades, we still do not have treatment methods that are safe and that can
Ballesteros, Sofia, Wendt, Alexander S, Sharma, Preeti, Brannelly, Laura A   +3 more
core   +1 more source

Fungicidal Activity and In Silico Studies of Triazoles Derived From Glycerol Against Neocosmospora falciformis, A Causal Agent of Guava Tree Decline

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Among seventeen 1,2,3‐triazoles synthetized from glycerol (4a–4q), compound 4l completely inhibited mycelial growth and eliminated N. falciformis spores at 1,000 µg/mL, exhibiting enhanced antifungalactivity and strong binding within the FsCYP51 active site, which highlights its promise as a lead candidate for antifungal development in both biological ...
Adilson Vidal Costa, Arêssa de Oliveira Correia, Breno Benvindo dos Anjos, Mariana Belizario de Oliveira, Poliana Aparecida Rodrigues Gazolla, Vagner Tebaldi de Queiroz, Juliana Alves Resende, Róbson Ricardo Teixeira, Osmair Vital de Oliveira, Gabriel Jacomin Vargas, Waldir Cintra de Jesus Júnior, Willian Bucker Moraes, Fábio Ramos Alves   +12 more
wiley   +1 more source

Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis

, 2010
Daoud Al-Badriyeh, Chin Fen Neoh, Kay Stewart, David CM KongCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Victoria, AustraliaAbstract: Fungal keratitis is one of the major causes of ophthalmic ...
Daoud Al-Badriyeh, Chin Fen Neoh, Kay Stewart, et al   +3 more
core