Results 91 to 100 of about 43,404 (216)

Pre-existing invasive fungal infection is not a contraindication for allogeneic HSCT for patients with hematologic malignancies: a CIBMTR study. [PDF]

, 2017
Patients with prior invasive fungal infection (IFI) increasingly proceed to allogeneic hematopoietic cell transplantation (HSCT). However, little is known about the impact of prior IFI on survival.
Aljurf, M, Auletta, JJ, Battiwalla, M, Boeckh, MJ, Brazauskas, R, Chen, M, Dvorak, CC, Gea-Banacloche, J, Geroge, B, Guinan, EC, Hale, GA, Lazarus, HM, Lee, J-W, Liesveld, JL, Lindemans, CA, Martino, R, Maziarz, RT, McLeod, AA, Ramanathan, M, Reddy, V, Riches, ML, Savani, BN, Smith, FO, Strasfeld, L, Taplitz, RA, Ustun, C, Wingard, JR   +26 more
core  

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Enhancing voriconazole therapy in liver dysfunction: exploring administration schemes and predictive factors for trough concentration and efficacy

Frontiers in Pharmacology
Introduction: The application of voriconazole in patients with liver dysfunction lacks pharmacokinetic data. In previous study, we proposed to develop voriconazole dosing regimens for these patients according to their total bilirubin, but the regimens ...
Yichang Zhao, Yichang Zhao, Huaiyuan Liu, Huaiyuan Liu, Chenlin Xiao, Chenlin Xiao, Jingjing Hou, Jingjing Hou, Bikui Zhang, Bikui Zhang, Jiakai Li, Jiakai Li, Min Zhang, Yongfang Jiang, Indy Sandaradura, Indy Sandaradura, Xuansheng Ding, Miao Yan, Miao Yan   +18 more
doaj   +1 more source

Digital Surveillance After Allogeneic Hematopoietic Stem Cell Transplantation Guides Therapeutic Interventions to Reduce Non‐Relapse Mortality

European Journal of Haematology, Volume 116, Issue 6, Page 937-942, June 2026.
ABSTRACT Introduction Allogeneic hematopoietic stem cell transplantation (HSCT) offers curative potential for many hematological malignancies; however, outcomes may be adversely affected by infections and transplant‐associated complications, contributing to non‐relapse mortality (NRM).
Lara Bischof, Katharina Egger‐Heidrich, Martin Schneider, Gregor Friedrich, Anna Massow, Johanna Vogelsang, Franziska Schmidt, Matthias Hänel, Thomas Illmer, Lynn Leppla, Alexandra Teynor, Sabina de Geest, Gabriele Muelller, Klaus H. Metzeler, Martin Bornhäuser, Uwe Platzbecker, Jan Moritz Middeke, Vladan Vučinić   +17 more
wiley   +1 more source

Voriconazole is a safe and effective anti-fungal prophylactic agent during induction therapy of acute myeloid leukemia

Indian Journal of Medical and Paediatric Oncology, 2016
Background: Antifungal prophylaxis (AFP) reduces the incidence of invasive fungal infections (IFIs) during induction therapy of acute myeloid leukemia (AML). Posaconazole is considered the standard of care.
Akash Shah, Prasanth Ganesan, Venkatraman Radhakrishnan, Krishnarathinam Kannan, Rejiv Rajendranath, Vandana Mahajan, Varalakshmi Vijayakumar, Trivadi Ganesan, Tenali Gnana Sagar   +8 more
doaj   +1 more source

Utility of Computed Tomography Surveillance of Asymptomatic Infection in Children and Young Adults Before Allogeneic Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
ABSTRACT Asymptomatic infection poses a significant risk for children undergoing hematopoietic stem cell transplantation (HSCT). Pre‐transplant surveillance computed tomography (CT) is commonly used to identify occult infection, though its diagnostic yield remains uncertain.
Tyler Obermark, Pradipta Debnath, Rama S. Ayyala, Lara A. Danziger‐Isakov, Jane Koo, Kasiani C. Myers, William R. Otto, Aki Tanimoto, Andrew T. Trout, Cara E. Morin   +9 more
wiley   +1 more source

_Trichoderma pseudokoningii_ Rifai isolation from Egyptian immunocompromised cattle with _Mycobacterium bovis_ infection [PDF]

, 2012
Recently, _Trichoderma_ species have emerged as potent fungal pathogens in immunocompromised humans. We report the first three cases of _Trichoderma pseudokoningii_ Rifai pulmonary infection in the Egyptian tuberculous dairy cattle with _Mycobacterium ...
Eman Khalifa, Helmy Torky
core   +1 more source

Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51) [PDF]

, 2015
Herein, we have investigated the amebicidal activities of the pharmaceutical triazole CYP51 inhibitors fluconazole, itraconazole, and voriconazole against Acanthamoeba castellanii and Acanthamoeba polyphaga and assess their potential as therapeutic ...
Andrew G. S. Warrilow, David C. Lamb, Diane E. Kelly, Josie E. Parker, Nicola J. Rolley, Stephen N. Smith, Steven L. Kelly, W. David Nes   +7 more
core   +1 more source

Application of Metagenomic Next‐Generation Sequencing in the Diagnosis of Pneumonia in Patients With Cancer

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background With the development of new sequencing technologies, metagenomic next‐generation sequencing (mNGS) has become a diagnostic tool for respiratory tract infections. Patients with cancer may develop pneumonia caused by infections or antitumor therapy.
Rong Qin, Chao Wang, Minghua Cong, Le Tian, Ning Li   +4 more
wiley   +1 more source