Results 81 to 90 of about 34,473 (219)

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Hyperlipidemia Caused by Voriconazole: A Case Report

Infection and Drug Resistance, 2021
Jiasheng Wu,1,2,* Na Chen,3,* Yake Yao,1 Jianying Zhou,1 Hua Zhou1 1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, People’s Republic of China;
Wu J, Chen N, Yao Y, Zhou J, Zhou H
doaj  

Influence of inflammation on voriconazole metabolism [PDF]

, 2015
Voriconazole pharmacokinetics shows a large inter- and intrapatient variability. Inflammation is associated with changes in the expression of CYP isoenzymes.
Encalada Ventura, MA, Alffenaar, J. -W. C., van den Heuvel, E. R., Groothuis, GMM, van den Heuvel, E.R., Groothuis, G.M.M., Span, L. F. R., Alffenaar, J-WC, Span, L.F.R., Groothuis, G. M. M., Span, Lambert F R, Ventura, M. A. Encalada, Alffenaar, J.W.C., Encalada Ventura, M.A., Heuvel, ER Edwin van den   +14 more
core   +3 more sources

Factors Affecting Voriconazole Trough Concentration and Optimal Maintenance Voriconazole Dose in Chinese Children

, 2021
Voriconazole is a triazole antifungal agent commonly used for the treatment and prevention of invasive aspergillosis (IA). However, the study of voriconazole\u27s use in children is limited.
Jing-Jing Hou, Indy Sandaradura, Chen-Lin Xiao, Bi-Kui Zhang, Yang Zou, Yi-Chang Zhao, Da-Xiong Xiang, Miao Yan, Jia-Kai Li   +8 more
core   +1 more source

Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management

MedComm, Volume 7, Issue 10, October 2026.
A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley   +1 more source

Pharmacoeconomics of voriconazole

, 2015
Voriconazole is a second-generation triazole that is a synthesized derivative of fluconazole. It first appeared in the US market in 2002. Voriconazole is available in oral and intravenous dosage forms, and does have excellent bioavailability.
Al-Badriyeh, Daoud
core   +2 more sources

Bioavailability of voriconazole in hospitalised patients [PDF]

, 2017
An important element in antimicrobial stewardship programmes is early switch from intravenous (i.v.) to oral antimicrobial treatment, especially for highly bioavailable drugs. The antifungal agent voriconazole is available both in i.v.
Vermeulen, Karin M, Kosterink, Jos G W; id_orcid, Alffenaar, Jan-Willem C, Zijlstra, Jan G, Geling, Sanne, Span, Lambert F R, Veringa, Anette, van der Werf, Tjip S, Kosterink, Jos G W, Zijlstra, Jan G; id_orcid   +9 more
core   +2 more sources

Therapeutic potential of a Bax inhibitor‐1/TMBIM6 antagonist (BIA) and its analogues in Aspergillus fumigatus‐induced asthma via dual targeting of AKT and epithelial‐derived inflammatory cytokines

British Journal of Pharmacology, Volume 183, Issue 19, Page 5975-5991, October 2026.
Background and Purpose Aspergillus fumigatus (A. fumigatus) exposure causes of severe allergic asthma, characterized by airway inflammation and epithelial dysfunction. TMBIM6 (Bax inhibitor‐1) has been implicated in airway epithelial stress responses and AKT signalling.
Young‐Jin Yu, Ahsan Ullah, Jisun Kim, Mehedi Hasan Bappi, Yerim Heo, Jin Hee Ahn, Hyun‐Kyoung Kim, Han‐Jung Chae   +7 more
wiley   +1 more source

Enhancing voriconazole therapy in liver dysfunction: exploring administration schemes and predictive factors for trough concentration and efficacy

Frontiers in Pharmacology
Introduction: The application of voriconazole in patients with liver dysfunction lacks pharmacokinetic data. In previous study, we proposed to develop voriconazole dosing regimens for these patients according to their total bilirubin, but the regimens ...
Yichang Zhao, Yichang Zhao, Huaiyuan Liu, Huaiyuan Liu, Chenlin Xiao, Chenlin Xiao, Jingjing Hou, Jingjing Hou, Bikui Zhang, Bikui Zhang, Jiakai Li, Jiakai Li, Min Zhang, Yongfang Jiang, Indy Sandaradura, Indy Sandaradura, Xuansheng Ding, Miao Yan, Miao Yan   +18 more
doaj   +1 more source

Effects of voriconazole on Cryptococcus neoformans [PDF]

, 2004
Voriconazole is a broad-spectrum triazole that offers extended activity against molds and yeasts that are not susceptible to earlier azole-type drugs. Recent studies indicate that melanization can severely reduce the susceptibility of certain antifungal ...
Casadevall A., Cleare W., Nosanchuk J.D., Van Duin D., Zaragoza O.   +4 more
core   +1 more source