Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. [PDF]
, 2016 Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Abdel-Mohsen, Mohamed +17 more
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Molecular Cancer, 2010 Background Uterine sarcomas are very rare malignancies with no approved chemotherapy protocols. Histone deacetylase (HDAC) inhibitors belong to the most promising groups of compounds for molecular targeting therapy.
Petru Edgar +6 more
doaj +1 more source
Research in Pharmaceutical Sciences, 2021 Background and purpose: In mammalian cells, several distinct surveillance systems, named cell cycle checkpoints, can interrupt normal cell-cycle progression.
Masumeh Sanaei, Fraidoon Kavoosi
doaj +1 more source
Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation [PDF]
, 2017 Current antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus ...
Albert, Brice J +8 more
core +2 more sources
Current Opportunities for Treatment Optimization of Mycosis Fungoides and Sezary Syndrome
Клиническая онкогематология, 2018 Aim. To estimate vorinostat efficacy in patients with relapsed/refractory mycosis fungoides and Sezary syndrome. Materials & Methods. The total of 21 patients with refractory and progressive mycosis fungoides and Sezary syndrome receiving vorinostat ...
Natal’ya Gennad’evna Chernova +1 more
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Nghiên cứu tương tác của vorinostat với enzyme HDAC8 (1T67) bằng Autodock
Tạp chí Khoa học Đại học Cần Thơ, 2020 Vorinostat là thuốc có khả năng ức chế enzyme HDAC, được FDA Hoa Kỳ phê duyệt năm 2006 điều trị u lympho tế bào T ở da. Trong số 18 loại enzyme HDAC, vorinostat ức chế mạnh hoạt động của enzyme HDAC1, HDAC2, HDAC3 và HDAC6.
Nguyễn Cường Quốc +3 more
doaj +1 more source
Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma
Cells, 2021 Depending on context and tumor stage, deregulation of autophagy can either suppress tumorigenesis or promote chemoresistance and tumor survival. Histone deacetylases (HDACs) can modulate autophagy; however, the exact mechanisms are not fully understood ...
Katharina Körholz +10 more
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Role of Erythromycin-Regulated Histone Deacetylase-2 in Benign Tracheal Stenosis
Canadian Respiratory Journal, 2020 Objective. This study aims to explore the role of erythromycin-regulated histone deacetylase-2 in benign tracheal stenosis. Methods. The rabbit model of tracheal stenosis was established. The rabbits were randomly divided into 8 groups.
Zhenjie Huang +5 more
doaj +1 more source
The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma [PDF]
, 2018 Background: The use of alkylating agents such as temozolomide in association with radiotherapy (RT) is the therapeutic standard of glioblastoma (GBM).
Chen, Yi +12 more
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Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer [PDF]
, 2019 Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, incurable cancer with a 20% 1 year survival rate. While standard-of-care therapy can prolong life in a small fraction of cases, PDAC is inherently resistant to current treatments, and novel ...
Adile, Ashley A. +19 more
core +3 more sources