Results 41 to 50 of about 24,005 (199)

Epigenetics in diagnosis, prognostic assessment and treatment of cancer:An update [PDF]

, 2014
Cancer cells contain multiple genetic and epigenetic changes. The relative specificity of many epigenetic changes for neoplastic cells has allowed the identification of diagnostic, prognostic and predictive biomarkers for a number of solid tumors and ...
Briasoulis, Evangelos, Crook, Tim, Hatzimichael, Eleftheria, Lagos, Konstantinos, Sim, Van Ren   +4 more
core   +4 more sources

Vorinostat: a histone deacetylases (HDAC) inhibitor ameliorates traumatic brain injury by inducing iNOS/Nrf2/ARE pathway

Folia Neuropathologica, 2018
The present investigation evaluates the protective effect of vorinostat on neuronal cells in the traumatic brain injury (TBI) and also postulates the possible mechanism of its action. Marmarou’s weight-drop model was used to induce the TBI.
Jinyu Xu, Jun Shi, Jiaming Zhang, Yun Zhang   +3 more
doaj   +1 more source

Quantitative Acetylomics Uncover Acetylation-Mediated Pathway Changes Following Histone Deacetylase Inhibition in Anaplastic Large Cell Lymphoma

Cells, 2022
Histone deacetylases (HDACs) target acetylated lysine residues in histone and non-histone proteins. HDACs are implicated in the regulation of genomic stability, cell cycle, cell death and differentiation and thus critically involved in tumorigenesis ...
Maša Zrimšek, Hana Kuchaříková, Kristina Draganić, Pavlína Dobrovolná, Verena Heiss Spornberger, Lisa Winkelmayer, Melanie R. Hassler, Gabriela Lochmanová, Zbyněk Zdráhal, Gerda Egger   +9 more
doaj   +1 more source

Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo [PDF]

, 2013
Targeted drugs have significantly improved the therapeutic options for advanced renal cell carcinoma (RCC). However, resistance often develops, negating the benefit of these agents.
Bartsch, Georg, Blaheta, Roman A., Haferkamp, Axel, Jüngel, Eva, Makarević, Jasmina, Nelson, Karen, Tsaur, Igor   +6 more
core   +2 more sources

Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. [PDF]

, 2017
SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane ...
Bufalieri, Francesca, Canettieri, Gianluca, Capalbo, Carlo, Coni, Sonia, DE SMAELE, Enrico, Di Magno, L, DI MARCOTULLIO, Lucia, Ferretti, Elisabetta, Kusio Kobialka, M, Mai, Antonello, Mancuso, ANNA BARBARA, Manni, Simona, Niewiadomski, P, Petroni, Marialaura, Rotili, Dante, Screpanti, Isabella, Sdruscia, Giulia, Serrao, SILVIA MARIA, Spiombi, Eleonora   +18 more
core   +2 more sources

Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma

Haematologica, 2010
Background Vorinostat (suberoylanilide hydroxamic acid, SAHA), an inhibitor of class I and II histone deacetylases, has been approved for the treatment of cutaneous T-cell lymphoma.
Magdalena B. Wozniak, Raquel Villuendas, James R. Bischoff, Carmen Blanco Aparicio, Juan F. Martínez Leal, Paloma de La Cueva, Ma Elena Rodriguez, Beatriz Herreros, Daniel Martin-Perez, Maria I. Longo, Marta Herrera, Miguel Á. Piris, Pablo L Ortiz-Romero   +12 more
doaj   +1 more source

Inhibition of histone deacetylation with vorinostat does not prevent tunicamycin-mediated acute kidney injury.

PLoS ONE, 2021
Endoplasmic reticulum (ER) stress is associated with acute kidney injury (AKI) caused by various mechanisms, including antibiotics, non-steroidal anti-inflammatory drugs, cisplatin, and radiocontrast.
Rachel E Carlisle, Salwa Farooqi, Ming Chan Zhang, Sarah Liu, Chao Lu, Andy Phan, Elise Brimble, Jeffrey G Dickhout   +7 more
doaj   +1 more source

Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy [PDF]

, 2017
Several histone deacetylase inhibitors including Vorinostat have received FDA approval for the treatment of haematological malignancies. However, data from these trials indicate that Vorinostat has limited efficacy as a monotherapy, prompting the need ...
Banerjee, Bates, Bershadsky, Bertrand, Castellino, Cheung, Cheung, Chou, de Sauvage, Dohner, Estey, Figg, Glass, Greally, Gu, Hall, Hu, Huang, Hughes, Johnstone, Johnstone, Kao, Kramer, Kwok, Lain, Langmead, Lehmann, Lewis, Longley, Marks, Melnick, Melnick, Mesirov, Mesirov, Niederwieser, Oehme, Pazdur, Pelicci, Peng, Prebet, Randolph, Reid, Reid, Richon, Roman-Gomez, Rowe, Salzberg, Scicinski, Thanos, Tohda, Vega, Yee, Zhang, Zhao, Zhao, Zhao, Zhao   +56 more
core   +3 more sources

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Biomarkers of histone deacetylase inhibitor activity in a phase 1 combined-modality study with radiotherapy.

PLoS ONE, 2014
BackgroundFollowing the demonstration that histone deacetylase inhibitors enhanced experimental radiation-induced clonogenic suppression, the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study, combining fractionated radiotherapy with daily vorinostat
Anne Hansen Ree, Marie Grøn Saelen, Erta Kalanxhi, Ingrid H G Østensen, Kristina Schee, Kathrine Røe, Torveig Weum Abrahamsen, Svein Dueland, Kjersti Flatmark   +8 more
doaj   +1 more source