Results 61 to 70 of about 24,005 (199)

Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment

Frontiers in Immunology, 2018
The greatest obstacle to a cure for HIV is the provirus that integrates into the genome of the infected cell and persists despite antiretroviral therapy.
Cory H. White, Nadejda Beliakova-Bethell, Nadejda Beliakova-Bethell, Steven M. Lada, Michael S. Breen, Tara P. Hurst, Celsa A. Spina, Celsa A. Spina, Douglas D. Richman, Douglas D. Richman, Douglas D. Richman, John Frater, Gkikas Magiorkinis, Christopher H. Woelk   +13 more
doaj   +1 more source

Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake

ChemistryOpen, EarlyView.
In this article, proteolysis targeting chimeras (PROTACs) bearing a polyamine linker capable of crossing cancer cell membranes via the polyamine transport system are synthesized and evaluated. The results provide valuable insights for the design of PROTACs with enhanced cellular uptake efficiency.
Yanran Liu, Wentian Chen, Yanwei Shang, Chaonan Tang, Xianming Zeng, Jun Li, Wenting Du   +6 more
wiley   +1 more source

Vorinostat Eliminates Multicellular Resistance of Mesothelioma 3D Spheroids via Restoration of Noxa Expression [PDF]

, 2013
When grown in 3D cultures as spheroids, mesothelioma cells acquire a multicellular resistance to apoptosis that resembles that of solid tumors. We have previously found that resistance to the proteasome inhibitor bortezomib in 3D can be explained by a ...
Barbone, Dario, Battula, Sailaja, Broaddus, V. Courtney, Bueno, Raphael, Bueno, Raphael, Busacca, Sara, Cheung, Priscilla, Gray, Steven G., Longley, Daniel B., Sugarbaker, David John   +9 more
core   +1 more source

The Evolution of Pneumocystis jirovecii Pneumonia Prophylaxis for Pediatric Patients With Extracranial Solid Tumors: A Review of Historical Insights and Future Directions

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pneumocystis jirovecii pneumonia (PJP) remains a modern‐day complication for pediatric patients receiving treatment for extracranial solid tumors (ST), highlighting the need for reconsideration of our current approach toward PJP prophylaxis. This critical review aims to evaluate both universal and risk‐stratified approaches to PJP prophylaxis ...
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG

Neoplasia: An International Journal for Oncology Research, 2021
ONC201/TIC10 activates TRAIL signaling through ATF4 and the integrated stress response (ISR). ONC201 demonstrated tumor regressions and disease stability in patients with histone H3K27M-mutated midline-glioma.
Yiqun Zhang, Lanlan Zhou, Howard Safran, Robyn Borsuk, Rishi Lulla, Nikos Tapinos, Attila A. Seyhan, Wafik S. El-Deiry   +7 more
doaj   +1 more source

Second malignancies in the context of lenalidomide treatment: an analysis of 2732 myeloma patients enrolled to the Myeloma XI trial. [PDF]

, 2016
We have carried out the largest randomised trial to date of newly diagnosed myeloma patients, in which lenalidomide has been used as an induction and maintenance treatment option and here report its impact on second primary malignancy (SPM) incidence and
A Brioli, A Palumbo, A Palumbo, A Palumbo, A Palumbo, AC Rawstron, B Barlogie, BG Durie, D Cunningham, D Pulte, GJ Morgan, J Cuzick, JL DePry, JP Fine, L Benboubker, M Attal, M Pintilie, MS Pepe, PL McCarthy, R Powles, RA Kyle, SK Kumar, SK Kumar, SV Rajkumar   +23 more
core   +2 more sources

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Vorinostat as potential antiparasitic drug.

European review for medical and pharmacological sciences, 2020
Vorinostat is a drug used to treat cutaneous T cell lymphoma whose action mechanism is based on Histone Deacetylase inhibition. Histone Deacetylases are a family of enzymes that remove acetyl groups from histone and non-histone proteins that control many crucial processes, such as gene regulation, cell cycle progression, differentiation, and apoptosis.
Herrera-Martínez, M., Orozco-Samperio, E., Montaño, S., Ariza-Ortega, J.A., Flores-García, Y., López-Contreras, L.   +5 more
openaire   +2 more sources

MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX). [PDF]

, 2017
A pancreatic ductal adenocarcinoma (PDAC), obtained from a patient, was grown orthotopically in the pancreatic tail of nude mice to establish a patient-derived orthotopic (PDOX) model.
Bouvet, Michael, Clary, Bryan M, Delong, Jonathan C, Hoffman, Robert M, Hwang, Ho Kyoung, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Lwin, Thinzar M, Murakami, Takashi, Unno, Michiaki   +10 more
core  

Epigenetic drug therapy in the treatment of colorectal cancer [PDF]

, 2018
Colorectal cancer (CRC) is one of the most common cancers with a high rate of morbidity and mortality worldwide. The incidence of CRC is similar in men and women but is distributed uniformly globally.
Avan, Amir, Esfehani, Reza Jafarzadeh, Ferns, Gordon A, Ghandehari, Maryam, Ghayour-Mobarhan, Majid, Hassanian, Seyed Mahdi, Khazaei, Majid, Moetamani-Ahmadi, Mehrdad, Parizadeh, Seyed Mohammad Reza, Parizadeh, Seyed Mostafa, Seifi, Sima   +10 more
core   +1 more source