Results 31 to 40 of about 9,619 (201)

The Bluetongue Disabled Infectious Single Animal (DISA) Vaccine Platform Based on Deletion NS3/NS3a Protein Is Safe and Protective in Cattle and Enables DIVA

Viruses, 2021
The bluetongue virus (BTV) is transmitted by Culicoides biting midges and causes bluetongue (BT), an OIE-notifiable disease of ruminants. At least 29 BTV serotypes are described as determined by the outer shell proteins VP2 and VP5.
Piet A. van Rijn, Mieke A. Maris-Veldhuis, René G. P. van Gennip   +2 more
doaj   +1 more source

Proteolysis of Monomeric Recombinant Rotavirus VP4 Yields an Oligomeric VP5* Core [PDF]

Journal of Virology, 2001
ABSTRACT Rotavirus particles are activated for cell entry by trypsin cleavage of the outer capsid spike protein, VP4, into a hemagglutinin, VP8*, and a membrane penetration protein, VP5*. We have purified rhesus rotavirus VP4, expressed in baculovirus-infected insect cells.
Dormitzer, Philip R., Greenberg, Harry B., Harrison, Stephen C.   +2 more
openaire   +4 more sources

A 3D model of the membrane protein complex formed by the white spot syndrome virus structural proteins. [PDF]

PLoS ONE, 2010
BACKGROUND: Outbreaks of white spot disease have had a large negative economic impact on cultured shrimp worldwide. However, the pathogenesis of the causative virus, WSSV (whit spot syndrome virus), is not yet well understood.
Yun-Shiang Chang, Wang-Jing Liu, Cheng-Chung Lee, Tsung-Lu Chou, Yuan-Ting Lee, Tz-Shian Wu, Jiun-Yan Huang, Wei-Tung Huang, Tai-Lin Lee, Guang-Hsiung Kou, Andrew H-J Wang, Chu-Fang Lo   +11 more
doaj   +1 more source

The Kinetics of VP5 mRNA Expression Is Not Critical for Viral Replication in Cultured Cells [PDF]

Journal of Virology, 2000
ABSTRACTWe generated recombinant viruses in which the kinetics of expression of the leaky-late VP5 mRNA was altered. We then analyzed the effect of such alterations on viral replication in cultured cells. The VP5 promoter and leader sequences from positions −36 to +20, containing the TATA box and an initiator element, were deleted and replaced with a ...
P T, Lieu, E K, Wagner
openaire   +2 more sources

The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca ²⁺

, 2023
ABSTRACT Rotaviruses infect cells by delivering into the cytosol a transcriptionally active inner capsid particle (a "double-layer particle": DLP). Delivery is the function of a third, outer layer, which drives uptake from the cell surface into small vesicles from which the DLPs escape.
Marilina De Sautu, Tobias Herrmann, Simon Jenni, Stephen C. Harrison   +3 more
openaire   +2 more sources

Identification and characterization of a novel non-structural protein of bluetongue virus [PDF]

, 2011
Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins.
Rixon, F., Palmarini, M., Ratinier Maxime, Ratinier, Maxime, Golder, Matthew, Nunes, S.F., Alessia Armezzani, Sandro Filipe Nunes, Kathryn Allan, Allan Kathryn, Allan, K., Rixon, Frazer, Golder, M., Allan, Kathryn, Nunes Sandro Filipe, Frazer Rixon, Bayoumy, Amr, Shaw, A., Matthew Golder, Franzoni, G., Caporale Marco, Giulia Franzoni, Golder Matthew, Nunes, Sandro Filipe, Bayoumy Amr, Shaw, Andrew, Amr Bayoumy, Palmarini Massimo, Armezzani, A., Shaw Andrew, Palmarini, Massimo, Ratinier, M., Armezzani, Alessia, Franzoni Giulia, Franzoni, Giulia, Maxime Ratinier, Andrew Shaw, Rixon Frazer, Marco Caporale, Massimo Palmarini, Armezzani Alessia, Bayoumy, A., Caporale, Marco, Caporale, M.   +43 more
core   +1 more source

Genetic and phylogenetic analysis of the outer capsid protein genes of Indian isolates of bluetongue virus serotype-16 [PDF]

Veterinary World, 2018
Aim: The aim of the study was to characterize bluetongue virus serotype 16 (BTV-16), recently isolated from different states of India. The evolutionary relationship of newly isolated BTV-16 and previously reported Indian and global BTV-16 isolates were ...
Arpit Saxena, Sanchay K. Biswas, Karam Chand, Jishnu Naskar, Ankita Chauhan, Gulam Mohd, Neha Tewari, Kurat-ul-Ain, Muthannan A. Ramakrishnan, Awadh Bihari Pandey   +9 more
doaj   +1 more source

Alternative intermolecular contacts underlie the rotavirus VP5* two‐ to three‐fold rearrangement [PDF]

The EMBO Journal, 2006
The spike protein VP4 is a key component of the membrane penetration apparatus of rotavirus, a nonenveloped virus that causes childhood gastroenteritis. Trypsin cleavage of VP4 produces a fragment, VP5*, with a potential membrane interaction region, and primes rotavirus for cell entry.
Joshua D, Yoder, Philip R, Dormitzer
openaire   +2 more sources

Primed for Discovery: Atomic-Resolution Cryo-EM Structure of a Reovirus Entry Intermediate

Viruses, 2010
A recently solved structure of the aquareovirus virion (Zhang, X; Jin, L.; Fang, Q; Hui, W.H.; Zhou Z.H. 3.3 Å Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry.
Shane D. Trask, Kristen M. Guglielmi, John T. Patton   +2 more
doaj   +1 more source

Differential Localization of Structural and Non-Structural Proteins during the Bluetongue Virus Replication Cycle

Viruses, 2020
Members of the Reoviridae family assemble virus factories within the cytoplasm of infected cells to replicate and assemble virus particles. Bluetongue virus (BTV) forms virus inclusion bodies (VIBs) that are aggregates of viral RNA, certain viral ...
Bjorn-Patrick Mohl, Adeline Kerviel, Thomas Labadie, Eiko Matsuo, Polly Roy   +4 more
doaj   +1 more source