Results 51 to 60 of about 8,749 (163)

Maize Biofortification Approaches for Fighting Malnutrition in Sub‐Saharan Africa

Plant-Environment Interactions, Volume 7, Issue 4, August 2026.
ABSTRACT Maize is a staple food in sub‐Saharan Africa (SSA); however, commonly used maize varieties are deficient in essential nutrients, including lysine, tryptophan, vitamin A, and minerals such as iron (Fe) and zinc (Zn). As a result, millions of people in this region suffer from one or more nutrient deficiencies that commonly lead to malnutrition ...
Bitew Tilahun Engida, Tesfaye Walle Mekonnen, Maryke Labuschagne   +2 more
wiley   +1 more source

Bivalent rotavirus VP4∗ stimulates protective antibodies against common genotypes of human rotaviruses

iScience, 2022
Summary: Non-replicating rotavirus vaccines are an alternative strategy to improve the efficacy and safety of rotavirus vaccines. The spike protein VP4, which could be enzymatically cleaved into VP8∗ and VP5∗, is an ideal target for the development of ...
Guoxing Luo, Yuanjun Zeng, Han Yang, Yijian Li, Lianwei Yang, Cao Li, Feibo Song, Shiyin Zhang, Tingdong Li, Shengxiang Ge, Jun Zhang, Ningshao Xia   +11 more
doaj   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, Volume 13, Issue 42, 28 July 2026.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Integrating proteomic and phosphoproteomic profiles provide new insights into ABA-dependent signal regulation network in maize response to heat stress

BMC Plant Biology
Background Heat stress (HS) negatively impacts crop yield and quality worldwide. Abscisic acid (ABA) is well known to play critical roles in stress responses.
Yanpei Liu, Yulong Zhao, Haiying Zhan, Shanshan Lv, Yanmin Luo, Wei Wang, Xiuli Hu   +6 more
doaj   +1 more source

N-Terminal Myristoylated VP5 is Required for Penetrating Cell Membrane and Promoting Infectivity in Aquareoviruses [PDF]

Virologica Sinica, 2018
Nonenveloped animal viruses must disrupt the host cell membrane to initiate infection. Although myristoylated outer capsid protein is known to be responsible for membrane penetration in nonenveloped viruses, the mechanisms underlying membrane penetration to enter the host cytoplasm remain poorly understood, compared to the membrane fusion mechanisms of
Qingxiu Chen, Hong Guo, Fuxian Zhang, Qin Fang   +3 more
openaire   +2 more sources

The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2+

PLOS Pathogens
Rotaviruses infect cells by delivering into the cytosol a transcriptionally active inner capsid particle (a "double-layer particle": DLP). Delivery is the function of a third, outer layer, which drives uptake from the cell surface into small vesicles from which the DLPs escape.
Marilina de Sautu, Tobias Herrmann, Gustavo Scanavachi, Simon Jenni, Stephen C. Harrison   +4 more
openaire   +3 more sources

Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein

Virology, 2015
Infectious Bursal Disease Virus (IBDV) causes a highly relevant poultry disease that affects young chickens causing, among other effects, immunosuppression. IBDV is a bi-segmented double stranded RNA virus. The smaller ORF of larger RNA segment encodes VP5, a 17-kDa non-structural protein. Although it is an important protein for viral replication cycle,
Carballeda, Juan Manuel, Maroniche, Guillermo Andrés, Lucero, María Soledad, Richetta, Matías Daniel, Gómez, Evangelina Raquel, Chimeno Zoth, Silvina Andrea, Berinstein, Analía   +6 more
openaire   +4 more sources

Whole‐Genome Characterization of Rare Artiodactyl‐Like G10P [14] and G8P [14] Rotavirus A Strains Detected in Pediatric Gastroenteritis Cases in Hokkaido Prefecture, Japan

Journal of Medical Virology, Volume 98, Issue 3, March 2026.
ABSTRACT Rotavirus alphagastroenteritidis (RVA) is the leading cause of acute gastroenteritis in young children worldwide, as well as in a wide range of animal species. In 2020 and 2022, we identified three unusual RVA strains in pediatric gastroenteritis patients in Hokkaido Prefecture, Japan, using next‐generation sequencing: one G10P[14] strain ...
Akira Takebayashi, Yuya Fukuda, Yoshiki Fujii, Hiroshi Nihira, Minako Kihara, Yoshimasa Kudou, Shuhei Adachi, Noritaka Shintani, Takeshi Tsugawa   +8 more
wiley   +1 more source

Genome‐wide association and haplotype analyses reveal genetic architecture of seed dormancy in grain sorghum with implications for preharvest sprouting tolerance

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Preharvest sprouting (PHS), triggered primarily by wet or humid conditions at maturity and further influenced by temperature, causes premature grain germination in sorghum (Sorghum bicolor (L.) Moench), reducing yield and grain quality. To elucidate the genetic architecture of seed dormancy and germination responses related to PHS tolerance ...
Yusa Ichinose, Dinesh Kumar Saini, Juliana M. Espíndola Lima, Gunvant B. Patil, Impa Somayanda, S. V. Krishna Jagadish   +5 more
wiley   +1 more source

Protection of IFNAR (-/-) mice against bluetongue virus serotype 8, by heterologous (DNA/rMVA) and homologous (rMVA/rMVA) vaccination, expressing outer-capsid protein VP2.

PLoS ONE, 2013
The protective efficacy of recombinant vaccines expressing serotype 8 bluetongue virus (BTV-8) capsid proteins was tested in a mouse model. The recombinant vaccines comprised plasmid DNA or Modified Vaccinia Ankara viruses encoding BTV VP2, VP5 or VP7 ...
Tamara Kusay Jabbar, Eva Calvo-Pinilla, Francisco Mateos, Simon Gubbins, Abdelghani Bin-Tarif, Katarzyna Bachanek-Bankowska, Oya Alpar, Javier Ortego, Haru-Hisa Takamatsu, Peter Paul Clement Mertens, Javier Castillo-Olivares   +10 more
doaj   +1 more source