Results 41 to 50 of about 8,749 (163)

The effect of pH on the structure of Bluetongue virus VP5

Journal of General Virology
The unenveloped Bluetongue virus capsid comprises several structural layers, the inner two comprising a core, which assembles before addition of the outer proteins, VP2 and VP5. Two symmetric trimers of VP5 fit like pegs into two distinct pits on the core and undergo pH conformational changes in the context of the virus, associated with cell entry ...
Hanwen Zhang, Kamel El Omari, Geoff Sutton, David I. Stuart   +3 more
openaire   +3 more sources

VP5 autocleavage is required for efficient infection by in vitro-recoated aquareovirus particles

Journal of General Virology, 2015
Grass carp reovirus (GCRV) is a member of the genus Aquareovirus in the family Reoviridae, and contains five core proteins (VP1-VP4 and VP6) and two outer-capsid proteins (VP5 and VP7) in its particle. Previous studies have revealed that the outer-capsid proteins of reovirus are responsible for initiating infection, but the mechanism is poorly ...
Shicui, Yan, Jie, Zhang, Hong, Guo, Liming, Yan, Qingxiu, Chen, Fuxian, Zhang, Qin, Fang   +6 more
openaire   +2 more sources

Membrane Composition Modulates Vp54 Binding: A Combined Experimental and Computational Study

Pathogens
The recruitment of peripheral membrane proteins is tightly regulated by membrane lipid composition and local electrostatic microenvironments. Our experimental observations revealed that Vp54, a viral matrix protein, exhibited preferential binding to ...
Wenhan Guo, Rui Dong, Ayoyinka O. Okedigba, Jason E. Sanchez, Irina V. Agarkova, Elea-Maria Abisamra, Andrew Jelinsky, Wayne Riekhof, Laila Noor, David D. Dunigan, James L. Van Etten, Daniel G. S. Capelluto, Chuan Xiao, Lin Li   +13 more
doaj   +1 more source

New insights into rotavirus entry machinery: stabilization of rotavirus spike conformation is independent of trypsin cleavage. [PDF]

PLoS Pathogens, 2014
The infectivity of rotavirus, the main causative agent of childhood diarrhea, is dependent on activation of the extracellular viral particles by trypsin-like proteases in the host intestinal lumen.
Javier M Rodríguez, Francisco J Chichón, Esther Martín-Forero, Fernando González-Camacho, José L Carrascosa, José R Castón, Daniel Luque   +6 more
doaj   +1 more source

Genetic Analysis of Field Isolates of Infectious Bursal Disease Virus in Iraqi Farms

The Iraqi Journal of Veterinary Medicine, 2020
Sixty samples of bursa of Fabricius were collected from broiler chickens suspected to be infected with infectious bursal disease virus (IBDV) in different areas of Iraq for molecular evaluation.
Rawaa S. Jumaa, Aida B. Allawi, Rebah N. Jabbar   +2 more
doaj   +1 more source

A putative cell surface receptor for white spot syndrome virus is a member of a transporter superfamily. [PDF]

PLoS ONE, 2012
White spot syndrome virus (WSSV), a large enveloped DNA virus, can cause the most serious viral disease in shrimp and has a wide host range among crustaceans.
Huai-Ting Huang, Jiann-Horng Leu, Po-Yu Huang, Li-Li Chen   +3 more
doaj   +1 more source

Interlayer‐Catalyst Method for Metal‐Assisted Chemical Etching of Ultra‐High Aspect Ratio Silicon Nanostructures

Small Methods, EarlyView.
An advanced patterning method is presented for metal‐assisted chemical etching. The interlayer replaces the resist and enables catalyst deposition on a clean interface. The prepared samples show improved performance with a more reproducible etching profile, higher aspect ratio, and increased consistency over a larger area.
Bryan Peter Jost Benz, Marco Stampanoni, Lucia Romano   +2 more
wiley   +1 more source

Selective Membrane Permeabilization by the Rotavirus VP5* Protein Is Abrogated by Mutations in an Internal Hydrophobic Domain [PDF]

Journal of Virology, 2000
ABSTRACT Rotavirus infectivity is dependent on the proteolytic cleavage of the VP4 spike protein into VP8* and VP5* proteins. Proteolytically activated virus, as well as expressed VP5*, permeabilizes membranes, suggesting that cleavage exposes a membrane-interactive domain of VP5* which effects rapid viral entry. The VP5* protein
W, Dowling, E, Denisova, R, LaMonica, E R, Mackow   +3 more
openaire   +2 more sources

Achieving Firm Ambidexterity Through Portfolio Management Meeting Conversations

Creativity and Innovation Management, EarlyView.
ABSTRACT The ability to pursue exploration and exploitation simultaneously has been extensively examined within the ambidexterity framework in creativity and innovation research. However, whether and how firm portfolio management meetings enable ambidexterity has not yet been identified by analyzing managers' conversations during such sessions ...
Claus J. Varnes, John K. Christiansen
wiley   +1 more source

Grass Carp (Ctenopharyngodon idellus) NIMA-Related Kinase 6 Blocks dsRNA-Induced IFN I Response by Targeting IRF3

Frontiers in Immunology, 2021
Accumulating evidence indicates that mammalian NIMA (never in mitosis, gene A)-related kinase 6 (NEK6) plays potential roles during the course of tumorigenesis, but little is known about NEK6 in lower vertebrates. Herein, we reported a mammalian ortholog
Xiaowen Xu, Meifeng Li, Zeyuan Deng, Jihuan Hu, Zeyin Jiang, Yapeng Liu, Kaile Chang, Chengyu Hu   +7 more
doaj   +1 more source