Therapeutic potential of vasoactive intestinal peptide and its receptor VPAC2 in type 2 diabetes [PDF]
Frontiers in Endocrinology, 2022 Owing to the increasing prevalence of type 2 diabetes, the development of novel hypoglycemic drugs has become a research hotspot, with the ultimate goal of developing therapeutic drugs that stimulate glucose-induced insulin secretion without inducing ...
Xintong Hou +13 more
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Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism [PDF]
Frontiers in Neuroscience, 2020 Clinical studies have shown that microduplications at 7q36.3, containing VIPR2, confer significant risk for schizophrenia and autism spectrum disorder (ASD).
Shuto Takeuchi +27 more
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Pathophysiological implication of the VPAC2 receptor in psychiatric disorders
Folia Pharmacologica Japonica, 2018 The advent of the genomic era has led to the discovery of linkages of several genes and pathways to schizophrenia and autism spectrum disorder (ASD) that may serve as new biomarkers or therapeutic targets for these diseases. Two large-scale genetic studies published early in 2011 provided evidence that functional microduplications at 7q36.3, containing
Yukio Ago +2 more
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The cell-autonomous clock of VIP receptor VPAC2 cells drives circadian behaviour [PDF]
, 2020 AbstractCircadian (∼daily) rhythms pervade mammalian behaviour. They are generated by cell-autonomous, transcriptional/translational feedback loops (TTFL), active in all tissues. This distributed clock network is co-ordinated by the principal circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN).
Ryan Hamnett +3 more
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VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model [PDF]
The Journal of Headache and PainBackground Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target.
Song Guo +13 more
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The Cell-Autonomous Clock of VIP Receptor VPAC2 Cells Regulates Period and Coherence of Circadian Behavior [PDF]
The Journal of Neuroscience, 2020 Circadian (approximately daily) rhythms pervade mammalian behavior. They are generated by cell-autonomous, transcriptional/translational feedback loops (TTFLs), active in all tissues. This distributed clock network is coordinated by the principal circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN).
Ryan Hamnett +3 more
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Figure S3 from VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer [PDF]
<p>Supplementary Figure</p>
Tenzin Passang +10 more
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Evidence for the involvement of VPAC1 and VPAC2 receptors in pressure‐induced vasodilatation in rodents [PDF]
The Journal of Physiology, 2003 A transient increase in skin blood flow in response to an innocuous local pressure application, defined as pressure‐induced vasodilatation (PIV), delays the occurrence of ischaemia, suggesting a protective feature against applied pressure. The PIV response depends on capsaicin‐sensitive nerve fibres and calcitonin gene‐related peptide (CGRP) has been ...
Lionel Fizanne +3 more
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Figure S2 from VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer [PDF]
<p>Supplementary Figure</p>
Tenzin Passang +10 more
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PAC1- and VPAC2 receptors in light regulated behavior and physiology: Studies in single and double mutant mice. [PDF]
PLoS ONE, 2017 The two sister peptides, pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) and their receptors, the PAC1 -and the VPAC2 receptors, are involved in regulation of the circadian timing system.
Jens Hannibal +2 more
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