Results 91 to 100 of about 3,084 (231)

The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors

open access: yesBritish Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander   +206 more
wiley   +1 more source

Tracing the Origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP)

open access: yesFrontiers in Neuroscience, 2020
Pituitary adenylate cyclase activating polypeptide (PACAP) is a well-conserved neuropeptide characteristic of vertebrates. This pluripotent hypothalamic neuropeptide regulates neurotransmitter release, intestinal motility, metabolism, cell division ...
João C. R. Cardoso   +2 more
doaj   +1 more source

Emerging Perspectives on Gonadotropin Regulation in Vertebrates Revealed by the Discovery of FSH‐RH in Teleosts

open access: yesBioEssays, Volume 47, Issue 11, November 2025.
Regarding pituitary gonadotropin regulation, recent studies have shown that in mammals, FSH and LH are regulated by a single GnRH (solo GnRH model), whereas in teleosts, they are regulated by CCK (FSH‐RH) and GnRH (LH‐RH), respectively (dual GnRH model).
Daichi Kayo   +3 more
wiley   +1 more source

Cyclic AMP signalling in pancreatic islets [PDF]

open access: yes, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian   +2 more
core   +1 more source

Immunomodulation With Local, Sustained Delivery of Pituitary Adenylate Cyclase Activating Polypeptide Results in Improved Functional Recovery in Stroke‐Injured Mice

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 24, September 18, 2025.
The tissue and functional benefits are demonstrated with local, sustained delivery of an anti‐inflammatory peptide, pituitary adenylate cyclase‐activating polypeptide (PACAP), for stroke treatment in a mouse model. Prolonged PACAP treatment modulated astrocyte and microglia toward pro‐reparative phenotypes, enhanced neuroprotection and preservation of ...
Eric Ho   +7 more
wiley   +1 more source

Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide and Vasoactive Intestinal Peptide Against Cognitive Decline in Neurodegenerative Diseases

open access: yesFrontiers in Cellular Neuroscience, 2020
Cognitive impairment is one of the major symptoms in most neurodegenerative disorders such as Alzheimer’s (AD), Parkinson (PD), and Huntington diseases (HD), affecting millions of people worldwide.
Irene Solés-Tarrés   +3 more
doaj   +1 more source

The effect of Xenin25 on spontaneous circular muscle contractions of rat distal colon in vitro

open access: yesPhysiological Reports, 2021
Xenin25 has a variety of physiological functions in the Gastrointestinal (GI) tract, including ion transport and motility. However, the motility responses in the colon induced by Xenin25 remain poorly understood.
Yuko Kuwahara   +4 more
doaj   +1 more source

G protein-coupled receptors: what a difference a 'partner' makes [PDF]

open access: yes, 2014
G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in essential physiological processes. GPCRs respond to a wide variety of ligands from light to large macromolecules, including hormones and small peptides. Unfortunately,
Abu-Helo   +190 more
core   +3 more sources

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

open access: yesBMEMat, Volume 3, Issue 3, September 2025.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu   +7 more
wiley   +1 more source

Interactions between BNST PACAP stress system and Estrous Cycling in Non-overiectomized Female Rats [PDF]

open access: yes, 2017
The objective of this investigation is to examine possible interactions between the BNST PACAP stress system and hormone levels during the estrous cycle of naturally cycling female rats.
Brumbaugh, Beniah
core   +1 more source

Home - About - Disclaimer - Privacy