Results 111 to 120 of about 3,084 (231)
Circadian clock disruption in neurodegenerative diseases: cause and effect? [PDF]
, 2015 Disturbance of the circadian system, manifested as disrupted daily rhythms of physiologic parameters such as sleep, activity, and hormone secretion, has long been observed as a symptom of several neurodegenerative diseases, including Alzheimer Disease ...
Erik S. Musiek
core +3 more sources
Caveolae-dependent internalization and homologous desensitization of VIP/PACAP receptor, VPAC2, in gastrointestinal smooth muscle [PDF]
Peptides, 2013 Abstract The main membrane proteins of caveolae (caveolin-1, -2 and -3) oligomerize within lipid rich domains to form regular invaginations of smooth muscle plasma membrane and participate in receptor internalization and desensitization independent of clathrin-coated vesicle endocytosis. We have previously shown that G s -coupled VIP/PACAP receptors,
Sunila Mahavadi +6 more
openaire +1 more source
GABAergic signalling in the suprachiasmatic nucleus is required for coherent circadian rhythmicity
European Journal of Neuroscience, Volume 60, Issue 11, Page 6652-6667, December 2024.Genetic disruption of GABAergic synaptic transmission by deletion of the vesicular GABA transporter within the suprachiasmatic nucleus of adult mice results in the eventual deterioration of physiological and behavioural rhythmicity in vivo and concomitant neuronal desynchrony in vitro.
Nathan Klett +9 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2019 Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is an endogenous neuropeptide with distinct functions including the regulation of inflammatory processes.
Caio Andreeta Figueiredo +9 more
doaj +1 more source
High expression of peptide receptors as a novel target in gastrointestinal stromal tumours [PDF]
, 2018 Recent significant advances in understanding the biology of gastrointestinal stromal tumours (GIST) have led to the introduction of a new targeted therapy (imatinib mesylate, Glivec).
Guillou, Louis +4 more
core
PACAP Enhances Barrier Properties of Cerebral Microvessels [PDF]
, 2014 Cerebral microvascular endothelial cells-coming in contact with pericytes and astrocytes-constitute the structural basis of the blood-brain barrier (BBB).
Fazakas, Csilla +5 more
core +2 more sources
A PACAP-38 citoprotektív és antiinflammatórikus hatásának vizsgálata vékonybél-autotranszplantációs modellben [PDF]
, 2013 Bevezetés: A vékonybél ischaemia-reperfusióval szembeni fokozott érzékenysége a szerv transzplantációjakor is jelen lévő probléma. Ismert a hypophysis adenilát-cikláz aktiváló polipeptid (PACAP) sejtvédő hatása.
Csukás, Domokos +9 more
core +1 more source
Journal of Neurochemistry, Volume 168, Issue 9, Page 3250-3267, September 2024.Pituitary adenylate cyclase‐activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are neuroprotective peptides. Their beneficial activities occur via three G protein‐coupled receptors, PAC1, VPAC1 and VPAC2. We found that PAC1 receptor activation contributes to most of the beneficial activities of the neuropeptides in an experimental ...
Margo I. Jansen +5 more
wiley +1 more source
An Overview of VPAC Receptors in Rheumatoid Arthritis: Biological Role and Clinical Significance
Frontiers in Endocrinology, 2019 The axis comprised by the Vasoactive Intestinal Peptide (VIP) and its G protein-coupled receptors (GPCRs), VPAC1, and VPAC2, belong to the B1 family and signal through Gs or Gq proteins.
Rosa P. Gomariz +9 more
doaj +1 more source
Investigation of the Possible Functions of PACAP in Human Trophoblast Cells [PDF]
, 2014 Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous neuropeptide having a widespread distribution both in the nervous system and peripheral organs including the female reproductive system.
Barakonyi, A. +10 more
core +1 more source