Results 11 to 20 of about 3,084 (231)

VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer [PDF]

Cancer Research
Abstract Pancreatic ductal adenocarcinoma (PDAC) harbors a complex tumor microenvironment, and cross-talk among cells in the tumor microenvironment can contribute to drug resistance and relapse. Vasoactive intestinal peptide (VIP) is overexpressed in PDAC, and VIP receptors expressed on T cells are a targetable pathway that sensitizes
Tenzin Passang, Shuhua Wang, Hanwen Zhang, Fanyuan Zeng, Po-Chih Hsu, Wenxi Wang, Jian-Ming Li, Yuan Liu, Sruthi Ravindranathan, Gregory B. Lesinski, Edmund K. Waller   +10 more
europepmc   +4 more sources

VPAC1 and VPAC2 Receptor Heterozygosity Confers Distinct Biological Properties to BV2 Microglial Cells [PDF]

Cells
Microglial cells, the resident immune cells of the central nervous system (CNS), are essential for maintaining CNS homeostasis. Dysregulation of microglial function is implicated in the pathogenesis of various neurodegenerative diseases.
Xin Ying Rachel Song, Margo Iris Jansen, Rubina Marzagalli, Giuseppe Musumeci, Velia D’Agata, Alessandro Castorina   +5 more
doaj   +4 more sources

VPAC2 receptor expression in human normal and neoplastic tissues: evaluation of the novel MAB SP235 [PDF]

Endocrine Connections, 2014
The vasoactive intestinal peptide receptor 2 (VPAC2) is widely distributed throughout the body and is also overexpressed in a variety of human neoplastic tissues. However, little is known about its precise tissue distribution, regulation and function, which is in part be due to the lack of specific monoclonal anti-VPAC2 antibodies.
Stefan Schulz, Anika Mann, Benjamin Novakhov, Hugh D. Piggins, Amelie Lupp   +4 more
europepmc   +4 more sources

Genome‐Wide Translatome Analysis Following Low‐Dose Ketamine to Reveal Novel Targets for Antidepressant Treatment [PDF]

Synapse, Volume 79, Issue 6, November 2025.
ABSTRACT Low‐dose ketamine is an efficacious antidepressant for treatment‐resistant unipolar and bipolar depressed patients. Major depressive disorder patients receiving a single infusion report elevated mood within 2 h, and ketamine's antidepressant effects have been observed as long as 7 days posttreatment.
Oliver H. Miller, Nils Grabole, Isabelle Wells, Ludovic Bellier, Jonathan J. Nassi, Benjamin J. Hall   +5 more
wiley   +2 more sources

Prokineticin 2 neurons form diverse subpopulations in the suprachiasmatic nucleus and rely on VPAC2-signaling for diurnal rhythmicity [PDF]

Frontiers in Physiology
IntroductionProkineticin 2 (PK2) is believed to function as an output molecule, relaying circadian rhythms of behavior and physiology from the suprachiasmatic nucleus (SCN).
Ida Stangerup, Ida Stangerup, Birgitte Georg, Jens Hannibal, Jens Hannibal   +4 more
doaj   +2 more sources

PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies [PDF]

Int J Mol Sci, 2022
Zoe Tasma, Andrew Siow, Paul W. R. Harris, Margaret A. Brimble, Simon J. O’Carroll, Debbie L. Hay, Christopher S. Walker   +6 more
openalex   +2 more sources

Development and pharmacological characterization of novel multi‐ calcitonin gene‐related peptide and pituitary adenylate cyclase‐activating peptide receptor antagonists [PDF]

Headache: The Journal of Head and Face Pain, Volume 65, Issue 7, Page 1064-1079, July/August 2025.
Abstract Objective This study aimed to provide proof‐of‐concept that multi‐receptor antagonist peptides can be generated by covalently linking independent antagonist peptides that block calcitonin gene‐related peptide (CGRP8‐37) or pituitary adenylate cyclase‐activating peptide (PACAP)/vasoactive intestinal peptide (VIP) (PACAP6‐38) activity ...
Zoe Tasma, Andrew Siow, Paul W. R. Harris, Margaret A. Brimble, Debbie L. Hay, Christopher S. Walker   +5 more
wiley   +2 more sources

Cardiac fibrosis induced by high‐fat diet in ApoE‐deficient male mice is exacerbated by genetic deletion of PACAP–PAC1 signaling [PDF]

Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.
Abstract Cardiac fibrosis is characterized by an excessive accumulation of extracellular matrix proteins and occurs in a variety of cardiac diseases, such as the highly prevalent syndrome heart failure with preserved ejection fraction (HFpEF) and other cardiac disorders.
J. M. Schubart, M. K. H. Schaefer, G. A. Bonaterra, L. Mey, H. Schwarzbach, S. Pankuweit, F. Ausbuettel, L. E. Eiden, S. Weyand, E. Weihe, R. Kinscherf, C. Waechter   +11 more
wiley   +2 more sources

Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target. [PDF]

PLoS ONE, 2014
Pituitary adenylate cyclase activating polypeptide (PACAP) is an important neurotrophic factor influencing differentiation of neuronal elements and exerting protecting role during traumatic injuries or inflammatory processes of the central nervous system.
Tamás Juhász, Csaba Matta, Éva Katona, Csilla Somogyi, Roland Takács, Pál Gergely, László Csernoch, Gyorgy Panyi, Gábor Tóth, Dóra Reglődi, Andrea Tamás, Róza Zákány   +11 more
doaj   +4 more sources

Loss of neuropeptide signalling alters temporal expression of mouse suprachiasmatic neuronal state and excitability [PDF]

European Journal of Neuroscience, Volume 60, Issue 11, Page 6617-6633, December 2024.
Abstract Individual neurons of the hypothalamic suprachiasmatic nuclei (SCN) contain an intracellular molecular clock that drives these neurons to exhibit day‐night variation in excitability. The neuropeptide vasoactive intestinal polypeptide (VIP) and its cognate receptor, VPAC2, are synthesized by SCN neurons and this intercellular VIP‐VPAC2 receptor
Sven Wegner, Mino D. C. Belle, Pi‐Shan Chang, Alun T. L. Hughes, Alexandra E. Conibear, Charlotte Muir, Rayna E. Samuels, Hugh D. Piggins   +7 more
wiley   +2 more sources