Results 191 to 200 of about 3,084 (231)

Impaired cardiorespiratory responses to hypercapnia in neonatal mice lacking PAC1 but not VPAC2 receptors

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2021
The evidence is mounting for a role for abnormal signaling of the stress peptide pituitary adenylate cyclase activating polypeptide (PACAP) and its canonical receptor PAC1 in the pathogenesis of sudden infant death syndrome. In this study, we investigated whether the PACAP receptors PAC1 or VPAC2 are involved in the neonatal cardiorespiratory response
Karlene T. Barrett, Shabih U. Hasan, Morris H. Scantlebury, Richard J. A. Wilson   +3 more
openaire   +2 more sources

Role of VPAC2 receptor in monocrotaline-induced pulmonary hypertension in rats

Journal of Applied Physiology, 2014
Pulmonary hypertension (PH) is associated with significant morbidity and mortality. Vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase activating peptide (PACAP) have pulmonary vasodilatory and positive inotropic effects via receptors VPAC1 and VPAC2, which possess a similar affinity for both peptides, and PAC1, a PACAP-preferring ...
Motokazu, Koga, Yusuke, Mizuno, Itaru, Watanabe, Hiromasa, Kawakami, Takahisa, Goto   +4 more
openaire   +2 more sources

Hexanoylation of a VPAC2 receptor-preferring ligand markedly increased its selectivity and potency

Peptides, 2004
We synthesized a VIP analog that combines mutations that decrease the affinity for the VPAC1 receptor but maintain a high affinity for the VPAC2 receptor with an amino-terminal hexanoylation that increases the affinity for the VPAC2 receptor with a limited decrease in the affinity of the VPAC1 receptor.
Langer, Ingrid, Grégoire, Françoise, Nachtergael, Ingrid, De Neef, Philippe, Vertongen, Pascale, Robberecht, Patrick   +5 more
openaire   +2 more sources

Expression of VPAC2 receptor and PAC1 receptor splice variants in the trigeminal ganglion of the adult rat

Molecular Brain Research, 2002
PACAP and VIP are members of the VIP/secretin/glucagon family of peptides with neurotransmitter, neuroprotective, and neurotrophic functions. PACAP and VIP are known to be upregulated in primary sensory neurons following nerve injury, implying that these neuropeptides could be mediators of sensory transmission in neuropathic pain states.
Priya, Chaudhary, Thomas K, Baumann
openaire   +2 more sources

VPAC2 receptor mediates VIP-potentiated insulin secretion via ion channels in rat pancreatic β cells

Experimental Cell Research, 2023
Vasoactive intestinal peptide (VIP), a small neuropeptide composing of 28 amino acids, functions as a neuromodulator with insulinotropic effect on pancreatic β cells, in which it is of vital importance in regulating the levels of blood glucose. VIP potently agonizes VPAC2 receptor (VPAC2-R).
Xin Zhao, Lijiao Deng, Lele Ren, Huanhuan Yang, Bin Wang, Xiaochan Zhu, Xiaoli Zhang, Chao Guo, Yi Zhang, Yunfeng Liu   +9 more
openaire   +2 more sources

In Silico Classification and Prediction of VIP Derivatives as VPAC1/ VPAC2 Receptor Agonists/Antagonists

Combinatorial Chemistry & High Throughput Screening, 2015
Vasoactive intestinal polypeptide (VIP) is an intrinsic 28-amino acid peptide, involved in a wide range of physiologic effects, and therefore considered as a promising drug candidate for the treatment of several diseases. But the clinical application of VIP has been limited for the easy in vivo digestion.
Jiazhong, Li, Xin, Wang, Huanxiang, Liu, Hongyu, Li   +3 more
openaire   +2 more sources

Development of Selective Ligands for Pac1, Vpac1 and Vpac2 Receptors

2003
At the time of its isolation, purification and sequencing in 1970-1972 by Said and Mutt (Said and Mutt, 1972;Mutt and Said, 1974), VIP was the third identified member of a peptide group that included secretin (Mutt et al, 1970) and glucagon (Bromer et al, 1957).
P. Robberecht, P. Vertongen, I. Langer, J. Perret   +3 more
openaire   +1 more source

VPAC2 Receptors Mediate Vasoactive Intestinal Peptide-Induced Neuroprotection against Neonatal Excitotoxic Brain Lesions in Mice

The Journal of Pharmacology and Experimental Therapeutics, 2005
Prepro-vasoactive intestinal peptide (VIP) mRNA codes for two neuropeptides: VIP and peptide histidine isoleucine (PHI). Two VIP receptors, shared with a similar affinity by pituitary adenylate cyclase-activating polypeptide (PACAP), have been cloned: VPAC(1) and VPAC(2). PHI binds to these receptors with a lower affinity.
Rangon, Claire-Marie, Goursaud, Stéphanie, Medja, Fadia, Lelièvre, Vincent, Mounien, Lourdes, Husson, Isabelle, Brabet, Philippe, Jégou, Sylvie, Janet, Thierry, Gressens, Pierre   +9 more
openaire   +3 more sources