Data from VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDAC) harbors a complex tumor microenvironment, and cross-talk among cells in the tumor microenvironment can contribute to drug resistance and relapse. Vasoactive intestinal peptide (VIP) is overexpressed in PDAC, and VIP receptors expressed on T cells are a targetable pathway that ...
Tenzin Passang +10 more
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Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia [PDF]
Biology Open, 2014 Summary Primary cilia protrude from the cell surface of many cell types in the human body and function as cellular antennae via ciliary membrane localized receptors. Neurons and glial cells in the brain possess primary cilia, and the malfunction of primary cilia may contribute to neurological deficits present in many cilia-associated ...
Livana Soetedjo +2 more
doaj +6 more sources
Figure S6 from VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer [PDF]
<p>Supplementary Figure</p>
Tenzin Passang +10 more
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Abundant Expression of Vasoactive Intestinal Polypeptide Receptor VPAC2 mRNA in Human Skin [PDF]
Journal of Investigative Dermatology, 2001 Tanja C. Fischer +7 more
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Modeling the VPAC2-Activated cAMP/PKA Signaling Pathway: From Receptor to Circadian Clock Gene Induction [PDF]
Biophysical Journal, 2005 Increasing evidence suggests an important role for VPAC2-activated signal transduction pathways in maintaining a synchronized biological clock in the suprachiasmatic nucleus (SCN). Activation of the VPAC2 signaling pathway induces per1 gene expression in the SCN and phase-shifts the circadian clock.
Haiping Hao +4 more
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PACAP-38 Induces Transcriptomic Changes in Rat Trigeminal Ganglion Cells Related to Neuroinflammation and Altered Mitochondrial Function Presumably via PAC1/VPAC2 Receptor-Independent Mechanism [PDF]
Int J Mol Sci, 2022 Krisztina Takács-Lovász +7 more
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Figure S4 from VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer [PDF]
<p>Supplementary Figure</p>
Tenzin Passang +10 more
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Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells [PDF]
BioFactors, Volume 50, Issue 6, Page 1148-1160, November/December 2024.Vasoactive intestinal peptide (VIP) acts as a promoter of human osteogenesis, enhancing the expression of early osteoblast markers and favoring both bone matrix formation and proper cytoskeletal reorganization. Moreover, VIP could be exerting a direct modulatory role on the osteoblast to osteoclast signaling by downregulating the receptor activator of ...
David Castro‐Vázquez +12 more
wiley +2 more sources
Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice [PDF]
Neurobiol Learn Mem, 2017 Yukio Ago +9 more
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VPAC1 and VPAC2 receptor deficiencies negatively influence pregnancy outcome through distinct and overlapping modulations of immune, trophoblast and vascular functions [PDF]
Biochim Biophys Acta Mol Basis Dis, 2022 Guillermina Calo +8 more
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