Results 41 to 50 of about 3,084 (231)

PM360. Overactivation of the VPAC2 receptor during the early postnatal period causes prefrontal synaptic abnormalities and cognitive dysfunction in mice [PDF]

Int J Neuropsychopharmacol, 2016
Yukio Ago, Atsuko Hayata, Takuya Kawanai, Ryosuke Yamauchi, James A. Waschek, Hitoshi Hashimoto   +5 more
openalex   +2 more sources

Drug Repositioning For Allosteric Modulation of VIP and PACAP Receptors

Frontiers in Endocrinology, 2021
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two neuropeptides that contribute to the regulation of intestinal motility and secretion, exocrine and endocrine secretions, and homeostasis of the ...
Ingrid Langer, Dorota Latek
doaj   +1 more source

Distribution of the VPAC2 Receptor in Peripheral Tissues of the Mouse [PDF]

Endocrinology, 2004
Abstract The neuropeptide vasoactive intestinal peptide (VIP) exerts its actions through two structurally related G protein-coupled receptors (VPAC1 and VPAC2). Pituitary adenylate cyclase-activating polypeptide (PACAP) is also a potent agonist of VPAC1 and VPAC2 receptors as well as of a third, PACAP-specific receptor (PAC1).
Anthony J, Harmar, W John, Sheward, Christine F, Morrison, Beatrice, Waser, Mathias, Gugger, Jean Claude, Reubi   +5 more
openaire   +2 more sources

Bordetella spp. utilize the type 3 secretion system to manipulate the VIP/VPAC2 signaling and promote colonization and persistence of the three classical Bordetella in the lower respiratory tract

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionBordetella are respiratory pathogens comprised of three classical Bordetella species: B. pertussis, B. parapertussis, and B. bronchiseptica. With recent surges in Bordetella spp.
Nicholas J. First, Jose Pedreira-Lopez, Manuel R. F. San-Silvestre, Katelyn M. Parrish, Xiao-Hong Lu, Monica C. Gestal   +5 more
doaj   +1 more source

Role of VPAC1 and VPAC2 receptors in the etiology of pregnancy rhinitis: an experimental study in rats

Brazilian Journal of Otorhinolaryngology, 2022
Introduction: Pregnancy rhinitis is a common sex hormone-related otorhinolaryngological disorder. There are some epidemiological and physiological studies on pregnancy rhinitis, but histopathological and biomolecular changes have not been studied ...
Burak Ulkumen, Muhammet Burak Batir, Burcu Artunc Ulkumen, Halil Gursoy Pala, Seda Vatansever, Sirri Cam   +5 more
doaj   +1 more source

Localization of the neuropeptides pituitary adenylate cyclase-activating polypeptide, vasoactive intestinal peptide, and their receptors in the basal brain blood vessels and trigeminal ganglion of the mouse CNS; an immunohistochemical study

Frontiers in Neuroanatomy, 2022
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are structurally related neuropeptides that are widely expressed in vertebrate tissues. The two neuropeptides are pleiotropic and have been associated with
Anne Marie Lund, Anne Marie Lund, Jens Hannibal, Jens Hannibal   +3 more
doaj   +1 more source

Cross-regulation of VPAC2 receptor internalization by m2 receptors via c-Src-mediated phosphorylation of GRK2 [PDF]

Regulatory Peptides, 2007
The aim of the study was to examine the mechanisms by which ACh, acting via m2 receptors, regulates GRK2-mediated VPAC(2) receptor desensitization in gastric smooth muscle cells. VIP induced VPAC(2) receptor phosphorylation and internalization in freshly dispersed smooth muscle cells.
Sunila, Mahavadi, Jiean, Huang, Wimolpak, Sriwai, Krothapalli R S S, Rao, Karnam S, Murthy   +4 more
openaire   +2 more sources

Effect of inactivating mutations on phosphorylation and internalization of the human VPAC2 receptor [PDF]

Journal of Molecular Endocrinology, 2005
The VPAC2 receptor, as all members of the G-protein-coupled receptor (GPCR)-B family, has two highly conserved motifs in the third intracellular (IC3) loop: a lysine and a leucine located at the amino-terminus and two basic residues separated by a leucine and an alanine at the carboxyl-terminus.
Langer, Ingrid, Langlet, Christelle, Robberecht, Patrick   +2 more
openaire   +2 more sources

Macrophage Resistance to HIV-1 Infection Is Enhanced by the Neuropeptides VIP and PACAP. [PDF]

PLoS ONE, 2013
It is well established that host factors can modulate HIV-1 replication in macrophages, critical cells in the pathogenesis of HIV-1 infection due to their ability to continuously produce virus.
Jairo R Temerozo, Rafael Joaquim, Eduardo G Regis, Wilson Savino, Dumith Chequer Bou-Habib   +4 more
doaj   +1 more source

Alterations in Gut Microbiota and Upregulations of VPAC2 and Intestinal Tight Junctions Correlate with Anti-Inflammatory Effects of Electroacupuncture in Colitis Mice with Sleep Fragmentation

Biology, 2022
The relationship between inflammatory bowel disease and sleep disturbances is complicated and of increasing interest. We investigated the inflammatory and immunological consequences of EA in sleep-deprived colitis and found that dextran sulfate sodium ...
Geng-Hao Liu, Xin-Cheng Zhuo, Yueh-Hsiang Huang, Hsuan-Miao Liu, Ren-Chin Wu, Chia-Jung Kuo, Ning-Hung Chen, Li-Pang Chuang, Shih-Wei Lin, Yen-Lung Chen, Huang-Yu Yang, Tzung-Yan Lee   +11 more
doaj   +1 more source