Results 71 to 80 of about 3,084 (231)

Development of therapeutics for the treatment of diabetic brain complications [PDF]

, 2014
Type-2 diabetes (T2D) is characterized by hyperglycemia and hyperlipidemia, resulting in impaired insulin production and insulin resistance in peripheral tissues.
Mansouri, Shiva
core   +1 more source

VIP Modulation of Hippocampal Synaptic Plasticity: A Role for VIP Receptors as Therapeutic Targets in Cognitive Decline and Mesial Temporal Lobe Epilepsy

Frontiers in Cellular Neuroscience, 2020
Vasoactive intestinal peptide (VIP) is an important modulatory peptide throughout the CNS acting as a neurotransmitter, neurotrophic or neuroprotective factor.
Diana Cunha-Reis, Diana Cunha-Reis, Ana Caulino-Rocha, Ana Caulino-Rocha   +3 more
doaj   +1 more source

Output from VIP cells of the mammalian central clock regulates daily physiological rhythms [PDF]

, 2020
The suprachiasmatic nucleus (SCN) circadian clock is critical for optimising daily cycles in mammalian physiology and behaviour. The roles of the various SCN cell types in communicating timing information to downstream physiological systems remain ...
A Kalsbeek, A Kalsbeek, A Kalsbeek, A Schroeder, AC West, AG Watts, AG Watts, AH Cheng, AJ Harmar, AT Hughes, C Gizowski, C Mazuski, CA Feillet, CS Colwell, DA Bechtold, DF Manvich, DH Loh, DJ Cutler, EE Abrahamson, ES Lein, ES Maywood, FK Stephan, H Taniguchi, H Wakamatsu, HT VanderLeest, HT vanderLeest, I Kallo, IT Lee, J Fahrenkrug, J Fan, J Hannibal, J Schaap, JA Evans, JA Evans, JE Quintero, JL Gomez, JR Jones, JR Jones, K Tanaka, L Hanna, L Madisen, L Mei, LD Alexander, LP Morin, LP Morin, M Howarth, M Mieda, MC Garnica-Siqueira, MJ Krashes, MR Ralph, MS Jasper, N Nunn, N Yamaguchi, P Indic, R Enoki, RL Spencer, RM Buijs, RY Moore, S Itoh, S Paul, SJ Aton, SK Lee, T Ikeno, T Kalamatianos, TJ Nakamura, TM Brown, TM Brown, TM Brown, TM Brown, TO Hermanstyne, WD Todd   +70 more
core   +1 more source

Potential PET Ligands for Imaging of Cerebral VPAC and PAC Receptors: Are Non-Peptide Small Molecules Superior to Peptide Compounds? [PDF]

, 2015
Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) have been known for decades to mediate neuroendocrine and vasodilative actions via G-protein-coupled receptors of Class B.
Pissarek, Margit
core   +1 more source

Pituitary adenylate cyclase activating peptide (PACAP) participates in adipogenesis by activating ERK signaling pathway. [PDF]

PLoS ONE, 2013
Pituitary adenylate cyclase activating peptide (PACAP) belongs to the secretin/glucagon/vasoactive intestinal peptide (VIP) family. Its action can be mediated by three different receptor subtypes: PAC1, which has exclusive affinity for PACAP, and VPAC1 ...
Tatjana Arsenijevic, Françoise Gregoire, Jeanne Chiadak, Elodie Courtequisse, Nargis Bolaky, Jason Perret, Christine Delporte   +6 more
doaj   +1 more source

VIP-induced neuroprotection of the developing brain. [PDF]

, 2011
International audienceExcitotoxicity is a key molecular mechanism of perinatal brain damage and is associated with cerebral palsy and long term cognitive deficits.
Gressens, Pierre, Passemard, Sandrine, Schwendimann, Leslie, Sokolowska, Paulina   +3 more
core   +2 more sources

Cutaneous nociception and neurogenic inflammation evoked by PACAP38 and VIP [PDF]

, 2010
Pituitary adenylate cyclase-activating peptide-38 (PACAP38) and vasoactive intestinal peptide (VIP) belong to the same secretin–glucagon superfamily and are present in nerve fibers in dura and skin.
A Arimura, A Fullerton, A Ottosson, A Rahmann, AM Drewes, AM Strassman, AM Strassman, B Fjellner, BJ Schueren Van der, CJ Dalsgaard, CJ Hovell, D Levy, D Levy, D Roosterman, DA Groneberg, E Schulze, Helle Holst, Henrik Winther Schytz, HW Schytz, J Hannibal, J Raud, J Seebeck, JB Warren, JD Mikkelsen, Jes Olesen, JM Hansen, K Jensen, L Dickson, L Lundeberg, L Odum, Lars Arendt-Nielsen, LH Lassen, LH Lassen, M Huttunen, M Schmelz, M Steinhoff, MA Ghatei, MA Moskowitz, Messoud Ashina, MV Savage, P Anand, P Gazerani, P Gazerani, P Sikand, R Burstein, R Burstein, R Rukwied, SD Brain, T Dickinson, T Wienecke, T Wienecke, TC Fischer, TC Theoharides, U Pedersen-Bjergaard, U Pedersen-Bjergaard   +54 more
core   +1 more source

Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies.

Frontiers in Endocrinology, 2012
VIP plays diverse and important role in human physiology and physiopathology and their receptors constitute potential targets for the treatment of several diseases such as neurodegenerative disorder, asthma, diabetes and inflammatory diseases.
Ingrid eLanger
doaj   +1 more source

Targeted deletion of PAC1 receptors in retinal neurons enhances neuron loss and axonopathy in a model of multiple sclerosis and optic neuritis

Neurobiology of Disease, 2021
Chronic inflammation drives synaptic loss in multiple sclerosis (MS) and is also commonly observed in other neurodegenerative diseases. Clinically approved treatments for MS provide symptomatic relief but fail to halt neurodegeneration and neurological ...
Christina Van, Michael C. Condro, Henly H. Ko, Anh Q. Hoang, Ruoyan Zhu, Kenny Lov, Patrick T. Ricaflanca, Anna L. Diep, Nhat N.M. Nguyen, Gerald S. Lipshutz, Allan MacKenzie-Graham, James A. Waschek   +11 more
doaj   +1 more source

Constant light enhances synchrony among circadian clock cells and promotes behavioral rhythms in VPAC(2)-signaling deficient mice [PDF]

, 2015
Individual neurons in the suprachiasmatic nuclei (SCN) contain an intracellular molecular clock and use intercellular signaling to synchronize their timekeeping activities so that the SCN can coordinate brain physiology and behavior.
A Power, A Schroeder, A Tapia-Osorio, AJ Harmar, AT Hughes, AT Hughes, AT Hughes, AT Hughes, AT Hughes, B Zheng, C Eastman, C Guilding, CP Coomans, CS Pittendrigh, D Abraham, D Ono, DA Bechtold, DJ Cutler, E Brooks, EA Lucassen, ED Herzog, ED Herzog, EJ Waite, ES Maywood, ES Maywood, FH Guldner, FJ Ebling, H Ohta, HC van Diepen, I Kallo, IT Lee, J Hannibal, J Hannibal, J LeSauter, J Myung, J Myung, JA Evans, JA Evans, JA Mohawk, JM Dragich, K Bae, K Spoelstra, KI Honma, M Mieda, M Munoz, M Sudo, MA Long, MM Canal-Corretger, NC Foley, OJ Marston, P Pakhotin, R Dallmann, S An, S An, S Pauls, S Steinlechner, SH Yoo, SJ Aton, SJ Kuhlman, SM Reppert, SY Park, T Yoshikawa, TM Brown, U Albrecht, VM Smith, WJ Schwartz, Y Yamaguchi   +66 more
core   +4 more sources