Results 211 to 220 of about 20,255 (238)

Human immunodeficiency virus type-1 Vpu inhibitor, BIT225, in combination with 3-drug antiretroviral therapy modulates inflammation and immune cells functions.

Journal of Infectious Diseases, 2020
BIT225 is a first in class inhibitor of HIV-1 Vpu. A phase II trial enrolled 36 HIV-1-infected, treatment-naïve participants in Thailand to receive standard of care antiretroviral therapy (ART) Atripla®, with 100 mg or 200 mg of BIT225 or placebo for 12 ...
C. Luscombe, A. Avihingsanon, K. Supparatpinyo, S. Gatechompol, W. M. Han, G. Ewart, A. Thomson, Michelle Miller, S. Becker, R. Murphy   +9 more
semanticscholar   +1 more source

Design, synthesis and biological evaluation of novel 2-(5-aryl-1H-imidazol-1-yl) derivatives as potential inhibitors of the HIV-1 Vpu and host BST-2 protein interaction.

European journal of medicinal chemistry, 2020
Novel ethyl 2-(5-aryl-1H-imidazol-1-yl)-acetates 17 and propionates 18, together with their acetic acid 19 and acetohydrazide 20 derivatives, were designed and synthesized using TosMIC chemistry. Biological evaluation of these newly synthesized scaffolds
T. J. Rashamuse, T. J. Rashamuse, Zikhona Njengele, Zikhona Njengele, E. M. Coyanis, Y. Sayed, Salerwe Mosebi, Moira L. Bode   +7 more
semanticscholar   +1 more source

Growth characteristics of SHIV without the vpu gene

International Journal of Molecular Medicine, 2001
NM-3 is a prototype of chimeric virus between simian and human immunodeficiency viruses (SHIV). It grows in monkey lymphocytic cells in vitro and in vivo as well as in human cells. A mutant designated NM3-E65, which lacks expression of the entire vpu gene, was constructed from NM-3, and monitored for its replication property.
A, Adachi, M, Miyaura, A, Sakurai, A, Yoshida, A H, Koyama, M, Fujita   +5 more
openaire   +2 more sources

Transmembrane Interactions of HIV-1 Vpu and Tetherin

Current HIV Research, 2012
Tetherin is a type II membrane protein that bears a N-terminal transmembrane domain, an extracellular coiled-coil structure and a C-terminal GPI anchor. This unique topology allows tetherin to block the release of a wide range of enveloped viruses from the cell surface.
Fei, Guo, Chen, Liang
openaire   +2 more sources

Phlorotannins as HIV Vpu inhibitors, an in silico virtual screening study of marine natural products

Biotechnology and applied biochemistry, 2020
The importance of new effective treatment methodologies for human immunodeficiency virus (HIV) is undeniable for the medical society. Viral protein U (Vpu), one of the disparaged accessory proteins of HIV, is responsible for the dissemination of viral ...
Mohammad Amin Langarizadeh, A. Abiri, Saeid Ghasemshirazi, Nazanin Foroutan, A. Khodadadi, E. Faghih‐Mirzaei   +5 more
semanticscholar   +1 more source

VPU – Managementverband mit politischer Durchsetzungskraft

Psych. Pflege Heute, 2015
Der Verband der Pflegedirektorinnen und Pflegedirektoren der Universitatskliniken und Medizinischen Hochschulen Deutschlands e. V. (VPU) ist ein Managementverband mit strategischen Zielen und politischer Durchsetzungskraft.
openaire   +1 more source

HIV Accessory Genes Vif and Vpu

2007
Publisher Summary This chapter describes the function of human immunodeficiency virus (HIV) accessory genes—vif and vpu. Primate immunodeficiency viruses, including HIV‐1, are characterized by the presence of a number of viral accessory genes that encompass vif, vpr, vpx, vpu, and nef.
openaire   +2 more sources

Assembling viral channel forming proteins: Vpu from HIV‐1

Biopolymers, 2013
Different routes of assembly are probed for the transmembrane domain (TMD) of the bitopic membrane protein Vpu from HIV‐1. Vpu is responsible for the amplification of viral release from the host cell. The mode of action includes (i) heteroassembly with host factors and (ii) the formation of homo‐oligomers, which are able to conduct ions across the ...
Li-Hua, Li, Hao-Jen, Hsu, Wolfgang B, Fischer   +2 more
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Engagierte Pflegedirektoren: Das Netzwerk Pflegeforschung des VPU

Pflegezeitschrift, 2017
Mit dem Ziel, die Pflege — analog der Hochschulmedizin — auf eine breite wissenschaftliche Basis zu stellen, die Verflechtung von Lehre, Forschung und Krankenversorgung zu starken und pflegebezogene Forschungsaktivitaten an Universitatskliniken zu bundeln, initiierte der VPU 2010 das Netzwerk Pflegeforschung.
openaire   +1 more source

Status of VPU development for PAL-XFEL

PAL-XFEL is planning to install second hard X-ray undulator line (HX2) to meet the high beamtime demand from the users. The photon energy range for the second hard X-ray beam line is from 2~ to 11 keV which is lower than the first hard X-ray photon energy range (2 ~ 20 keV).
Jung,YoungGyu, Kim,Beom Jun, Kim,Changbum, Kim,Dong Eon, Park,Ki-Hyeon, Lee,Woul Woo, Choi,yoongeol   +6 more
openaire   +1 more source