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Interactions of Viral protein U (Vpu) with Cellular Factors
2009Viral protein U (Vpu) is encoded by one of several accessory genes of HIV-1. Like the accessory gene products Vif and Vpr, Vpu targets host proteins such as CD4 for degradation via the recruitment of cellular multi-subunit ubiquitin ligases. Vpu also forms ion channels in cellular membranes. Through one or both of these attributes, Vpu antagonizes host
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HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms
Molecular Aspects of Medicine, 2010Klaus Strebel
exaly

