Results 91 to 100 of about 8,926 (229)

Structural analysis of the flexibility of the Ubl2 domain within the papain‐like protease of SARS‐CoV‐2

Acta Crystallographica Section F, Volume 82, Issue 6, Page 222-230, June 2026.
The ubiquitin‐like domain 2 (Ubl2) of the SARS‐CoV‐2 virus is necessary for the stability and catalytic efficiency of its papain‐like protease (PLpro). Our crystallographic study reveals that the Ubl2 domain exhibits notable flexibility and can adopt a conformation that places itself away from the PLpro catalytic domain, representing a new conformation
Gian Luca Freiherr von Scholley, Martina Schaefer, Mark D. Tully, Marc-Andre Hograindleur, Montserrat Soler-López, Roman C. Hillig, Christoph Mueller-Dieckmann, Eaazhisai Kandiah   +7 more
wiley   +1 more source

The Duodenal Mucosa Plays a Key Role in Metabolic Regulation: Emerging Physiology and New Opportunities for Cell‐Directed and Barrier‐Related Interventions for the Treatment of Diabetes and Obesity

Diabetes, Obesity and Metabolism, Volume 28, Issue S3, Page 3-15, June 2026.
ABSTRACT The duodenum has historically been regarded as a passive digestive conduit for nutrient transit and absorption. However, emerging experimental and clinical evidence supports a revision of this view. In a contemporary model, the proximal small intestine also has roles as a metabolic sensor and endocrine signalling hub that exerts a powerful ...
David A. D’Alessio, Jonathan E. Campbell   +1 more
wiley   +1 more source

Alignment on VSG LiTat 1.3 of peptides selected with anti-VSG LiTat 1.3 antibody fractions.

, 2013
Homologous sequences between phage displayed peptides and/or the protein sequence of VSG LiTat 1.3 are indicated in grey. Amino acids that are identical to those of the VSG protein sequence are in bold and grey.
Tessa Dieltjens (319615), Fatima Balharbi (319614), Yves Guisez (319616), Veerle Lejon (116133), Liesbeth Van Nieuwenhove (319612), Philippe Büscher (150731), Michael Humbert (156782)   +6 more
core   +1 more source

Performance Evaluation of Automated Flood Inundation Mapping Techniques Using Multi‐Temporal Sentinel‐1 SAR Data

Journal of Flood Risk Management, Volume 19, Issue 2, June 2026.
ABSTRACT In recent times, the development of algorithms to delineate water surface maps has significantly boosted flood monitoring and mitigation efforts by utilizing dual polarization, multi‐temporal Sentinel‐1 synthetic aperture radar (SAR) data. The Sentinel‐1 mission, with its global land monitoring capability, has been widely employed for SAR ...
Gautam Dadhich, Mukand Babel, Hiroyuki Miyazaki, Indrajit Pal, Nitin Kumar Tripathi, Salvatore G. P. Virdis   +5 more
wiley   +1 more source

Alignment on VSG LiTat 1.5 of peptides selected with anti-VSG LiTat 1.5 antibody fractions.

, 2013
Homologous sequences between phage displayed peptides and/or the protein sequence of VSG LiTat 1.5 are indicated in grey. Amino acids that are identical to those of the VSG protein sequence are in bold and grey.
Tessa Dieltjens (319615), Fatima Balharbi (319614), Yves Guisez (319616), Veerle Lejon (116133), Liesbeth Van Nieuwenhove (319612), Philippe Büscher (150731), Michael Humbert (156782)   +6 more
core   +1 more source

Life and times: synthesis, trafficking, and evolution of VSG

Trends in Parasitology, 2014
Evasion of the acquired immune response in African trypanosomes is principally mediated by antigenic variation, the sequential expression of distinct variant surface glycoproteins (VSGs) at extremely high density on the cell surface. Sequence diversity between VSGs facilitates escape of a subpopulation of trypanosomes from antibody-mediated killing ...
Manna, Paul T., Boehm, Cordula, Leung, Ka Fai, Natesan, Senthil Kumar, Field, Mark C.   +4 more
openaire   +3 more sources

Ligand‐Based Pharmacophore Modeling and Structure‐Based Virtual Screening for Identifying Potential Therapeutic Agents Targeting the SARS‐CoV‐2 Spike Protein‐ACE2 Receptor Interaction

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
A protocol guided by ligand‐based pharmacophore modeling and structure‐based virtual screening enabled the identification of 1H‐pyrazol‐5‐ol derivatives as novel inhibitors of the SARS‐CoV‐2 spike protein. The lead inhibitors, C‐3 and C‐4, could serve as templates for the design of potent antiviral agents targeting viral entry into host cells ...
Timoteo Delgado‐Maldonado, Gilberto Vargas‐Salas, Debasish Bandyopadhyay, Adriana Moreno‐Rodríguez, Eyra Ortiz‐Pérez, Gildardo Rivera   +5 more
wiley   +1 more source

VSG recognition by Nbs.

, 2013
A) Rate plane with Isoaffinity Diagonals (RaPID) plot of Nb_An05 and the Nb_An05 mutants, Nb_An46 and Nb_An33 to VSG. The kinetic rate values kon and koff for a particular Nb to VSG determined via surface plasmon resonance are plotted on a two ...
Benoît Stijlemans (119880), Lea Brys (349654), Patrick De Baetselier (52141), Serge Muyldermans (24113), Mark C. Field (129657), David Pérez-Morga (2886368), Jeremy N. Skepper (164101), Etienne Pays (256328), Senthil Kumar A. Natesan (259144), Guy Caljon (119879), Stefan Magez (52136), Katja Conrath (349652), Dirk Saerens (119881), Alexandros Nikolaou (349653)   +13 more
core   +1 more source

Study of Bursting Oscillations in VSG System With External Excitation

IEEE Access
When the virtual synchronous generator (VSG) is subjected to an external excitation and the frequency of the external excitation is much smaller than the intrinsic frequency of the VSG system, the VSG system will experience bursting oscillations, leading
Kuanmin Wei, Xiaobing Wang, Jingda Gu, Liuxue Li   +3 more
doaj   +1 more source

Modified virtual synchronous generator based‐primary frequency regulation for renewable generation integrated into power system

IET Generation, Transmission & Distribution, 2020
To guarantee the frequency stability of renewable energy sources (RESs) generation integrated into the power system, primary frequency regulation (PFR) for RES generation controlled by virtual synchronous generator (VSG) has been concerned extensively ...
Zhengyang Hu, Bingtuan Gao, Ning Chen, Linan Qu, Chenyu Peng   +4 more
doaj   +1 more source