Results 91 to 100 of about 1,382,065 (344)

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Predictors of Bangladeshi registered nurses' disaster management knowledge, skills, and preparedness

Progress in Disaster Science
As a primary healthcare first respondent during disasters, Bangladeshi registered nurses (RNs) play a critical role in disaster management. This study assessed their knowledge, skills, and preparedness (KSP) for disaster management and examined the ...
Md. Khalid Hasan, Ahmed Fahmi, Tasnim Jamal Jisa, Rokibul Huq Rokib, Julia Yasmin Borna, Jannatul Fardusi, Israt Jahan Oishee, Anas, Sheikh Abdullah Al Muid, Sadia Afrin Saki, Shariful Islam, Md. Solayman Uddin, Md. Shihab Mahmud   +12 more
doaj  

Impacts of flow regime characterization on selected water quality parameters in Mthatha River catchment

Water Practice and Technology
The effects of altered streamflow types on selected water quality parameters provide useful knowledge and information for prompt water pollution management. This study assesses the impacts of inter- and intra-year seasonal variability in streamflow types
Oseni Taiwo Amoo, Nombuyiselo Makupula, Ikudayisi Akinola, Motebang Dominic Vincent Nakin   +3 more
doaj   +1 more source

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Nature, 2021
Chao Mao, Xiaoguang Liu, Yilei Zhang, Guang Lei, Yuelong Yan, Hyemin Lee, Pranavi Koppula, Shiqi Wu, Zhuang Li, B. Fang, M. Poyurovsky, Kellen L. Olszewski, B. Gan   +12 more
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

On Psychological Growth and Vulnerability: Basic Psychological Need Satisfaction and Need Frustration as a Unifying Principle

, 2013
Humans have a potential for growth, integration, and well-being, while also being vulnerable to defensiveness, aggression, and ill-being. Self-determination theory (R. M. Ryan & E. L.
M. Vansteenkiste, Richard M. Ryan
semanticscholar   +1 more source

SARS‐CoV‐2 Is Linked to Brain Volume Loss in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The impact of SARS‐CoV‐2 infection on brain and spinal cord pathology in patients with multiple sclerosis (pwMS) remains unclear. We aimed to describe changes in brain lesion activity and brain and spinal cord volumes following SARS‐CoV‐2 infection.
Tomas Uher, Dominika Stastna, Ingrid Menkyova, Vaclav Capek, Jiri Lindner, Petra Nytrova, Jan Krasensky, Eliza Varju, Miguel D'haeseleer, Eva Kubala Havrdova, Dana Horakova, Manuela Vaneckova, Niels Bergsland   +12 more
wiley   +1 more source

Amyotrophic Lateral Sclerosis as a Multistep Process in the United States: A Population‐Based Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease that typically results in death within 3–5 years from symptom onset. However, little is known about the environmental exposures, clinical aspects, or social determinants of health factors that may be associated with the disease.
Jasmine Berry, Jaime Raymond, Theodore Larson, D. Kevin Horton, Moon Han, Theresa Nair, Ammar Al‐Chalabi, Paul Mehta   +7 more
wiley   +1 more source

THE VULNERABILITY OF BALSAM FIR TO SPRUCE BUDWORM ATTACK IN NORTHWESTERN ONTARIO, WITH SPECIAL REFERENCE TO THE PHYSIOLOGICAL AGE OF THE TREE [PDF]

, 1958
J. R. Blais
openalex   +1 more source