Results 51 to 60 of about 199,054 (253)

Development of the vulnerability assessment model of explosive terrorism in multi-use buildings

Journal of Asian Architecture and Building Engineering, 2019
The purpose of this study is to develop a vulnerability assessment model of explosive terrorism in multi-use buildings focusing mainly on architectural design elements.
Kyung-Yeon Kang, So-Yeon Park, Hong Heo, Myung-Sik Lee, Kyung-Hoon Lee   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Towards a verifiable, uncertainty-controlled assessment of the spatiotemporal dynamics of social vulnerability to flash floods

Ecological Indicators
While research on quantitative measures of vulnerability is increasing, current studies may be criticized for failing to consider the spatiotemporal dynamics of vulnerability, ignoring uncertainty in the assessment process, and lacking validation.
Xinjun He, Yiping Fang, Baosheng Wang, Xueyuan Huang   +3 more
doaj   +1 more source

Vulnerability Assessment of Dwelling Buildings [PDF]

, 2006
Risk is defined as the potential economic, social and environmental consequences of hazardous events that may occur in a specified area unit and period. The evaluation of physical vulnerability and risk of buildings is the main purpose of this chapter. Nevertheless, it is shown the necessity of considering not only the expected physical damage but also
Barbat, Alex, Lagomarsino, S., Pujades, L.   +2 more
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Research on key technology of vulnerability threat classification

Tongxin xuebao, 2012
In order to solve the vulnerability assessment problem of vulnerability management,three attribute groups were selected to qualitatively evaluate vulnerability threat.After the selection of vulnerability attributes,analytic hierarchy process method was ...
Qi-xu LIU, Chong-bin ZHANG, Yu-qing ZHANG, Bao-feng ZHANG   +3 more
doaj   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Design and implementation of a vulnerability assessment system for oil and gas pipelines in Natech events

You-qi chuyun
[Objective] The oil and gas conveyed in transmission pipelines are highly flammable and explosive. During natural disasters,these pipelines are susceptible to technological accidents such as fire, explosion, and environmental pollution, i.e.
CHEN Guohua, TAO Xia, ZHOU Lixing
doaj   +1 more source