Results 61 to 70 of about 5,815,285 (328)

AN INDICATOR-BASED APPROACH FOR MICRO-SCALE PHYSICAL FLOOD VULNERABILITY MAPPING [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
Map representation of vulnerability is a crucial step in evaluating flood impact and all vulnerability indicators that are the final product of risk assessment. So far, in flood risk assessment, this is probably the weakest link.
I. U. Kaoje, M. Z. Abdul Rahman, T. H. Tam, M. R. Mohd Salleh   +3 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Progress in Climate–Agricultural Vulnerability Assessment in Nigeria

Atmosphere, 2020
An in-depth understanding of the impact of vulnerability on livelihoods and food security is important in deploying effective adaptation actions. The Nigerian agricultural sector is dominated by rainfed and non-homogenous smallholder farming systems.
R. Onyeneke, C. Emenekwe, J. Munonye, C. Nwajiuba, U. I. Uwazie, M. Amadi, C. Izuogu, Chukwudi Loveday Njoku, Louis Uchenna Onyeneke   +8 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Seismic Vulnerability Assessment of Historic Constructions in the Downtown of Mexico City

Sustainability, 2020
Seismic risk is determined by the sum of multiple components produced by a certain seismic intensity, being represented by the seismic hazard, the structural vulnerability and the exposure of assets at a specified zone. Most of the methods and strategies
L. G. F. Salazar, T. Ferreira
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Automated Software Vulnerability Assessment with Concept Drift [PDF]

IEEE Working Conference on Mining Software Repositories, 2019
Software Engineering researchers are increasingly using Natural Language Processing (NLP) techniques to automate Software Vulnerabilities (SVs) assessment using the descriptions in public repositories.
T. H. Le, Bushra Sabir, M. Babar
semanticscholar   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Development of the vulnerability assessment model of explosive terrorism in multi-use buildings

Journal of Asian Architecture and Building Engineering, 2019
The purpose of this study is to develop a vulnerability assessment model of explosive terrorism in multi-use buildings focusing mainly on architectural design elements.
Kyung-Yeon Kang, So-Yeon Park, Hong Heo, Myung-Sik Lee, Kyung-Hoon Lee   +4 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source