Results 71 to 80 of about 570,867 (306)

The Arctic Permafrost Vulnerability Index

Sustainability
As permafrost thaw accelerates, Arctic communities living on permafrost face new challenges that require the development of local adaptation policies. Vulnerability assessments have not yet been applied in the context of permafrost thaw. We develop a conceptual framework to assess vulnerabilities related to permafrost thaw in the Arctic Circumpolar ...
Ramage, Justine, Vasilevskaya, Anna, Heleniak, Timothy, Jungsberg, Leneisja, Cordier, Mateo, Stella, Elisa, Westermann, Sebastian, Larsen, Joan   +7 more
openaire   +2 more sources

Exposer Intensity, Vulnerability Index And Landscape Change Assessment In Olomouc, Czech Republic [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015
The objective of this study is vulnerability and exposer intensity due to land use change in Olomouc, Czech Republic. Vulnerability assessment with exposer intensity to land use/cover change is an important step for enhancing the understanding and ...
M. S. Boori, V. Vozenilek, K. Choudhary
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Measuring the Vulnerability of Subnational Regions [PDF]

A small but growing literature has been concerned about the economic (and environmental) vulnerability on the level of countries. Less attention is paid to the economic vulnerability of different regions within countries. By focusing on the vulnerability
McGillivray, Mark, Naude, Wim, Rossouw, Stephanie   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Indice de vulnerabilidad estructural ante los efectos de remoción en masa en edificaciones de mampostería basado en conjuntos difusos Structural vulnerability index to the effects of landslides in masonry buildings based on fuzzy sets

Revista Ingeniería de Construcción, 2012
En este trabajo se presenta un modelo rápido y sencillo de evaluación de la vulnerabilidad estructural de edificaciones a escala regional. El modelo fue construido de forma que puede ser aplicado especialmente a zonas donde no se cuenta con información ...
Esperanza Maldonado Rondón, Gustavo Chio Cho   +1 more
doaj  

A Framework for Effective Multi-Hazard Risk Assessment in Post-Mining Areas

Safety
This work presents a structured methodology for multi-hazard risk assessment in post-mining coal areas, addressing the complex interactions between natural, mining, and technological hazards.
Dafni M. Nalmpant-Sarikaki, Alexandros I. Theocharis, Nikolaos C. Koukouzas, Ioannis E. Zevgolis   +3 more
doaj   +1 more source

Vulnerability to Agricultural Drought in Western Orissa: A Case Study of Representative Blocks [PDF]

The nature of vulnerability to agricultural drought in three study blocks of Bolangir district in western Orissa has been analysed. The indexing and vulnerability profile method have been used for assessing the nature of drought vulnerability, coping ...
Swain, Mamata, Swain, Mrutyunjay
core   +1 more source

A systematic review of coastal vulnerability assessment studies along Andhra Pradesh, India: A critical evaluation of data gathering, risk levels and mitigation strategies [PDF]

, 2019
The establishment and alteration of any coastal feature is largely dependent upon complex hydrological and geomorphologic processes. Therefore, understanding hazard factors and threat risk level is crucial for mitigating risk in coastal zones. This study
Komali Kantamaneni, N.N.V. Sudha Rani, Louis Rice, Koyel Sur, Menaha Thayaparan, Udayangani Kulatunga, Rajshree Rege, Komali Yenneti, Luiza Campos, Vivek, Patwardhan, Ramesh, Nicholls, Dow, Lal, McCarthy, Chen, Parry, Chandrasekar, Appelquist, Gilard, Pavri, Rao, Kaliraj, Thakur, Venkataraman, Gornitz, Kumar, Kavya, Kumari, Topno   +30 more
core   +4 more sources