Results 101 to 110 of about 76,465 (345)

Sex Differences in Associations of Lewy Body Disease with Alzheimer's Disease and Cognitive Decline

Annals of Neurology, EarlyView.
Objective To investigate how sex and age at menopause influence the interplay between Alzheimer's disease (AD) and Lewy body disease (LBD) neuropathologies, and their associations with cognitive decline. Methods We analyzed data from: (1) three Rush Alzheimer's Disease Center cohorts (i.e., the Religious Orders Study, Rush Memory and Aging Project, and
Madeline Wood Alexander, D. Luke Fischer, Lawren VandeVrede, Emma Nichols, Lei Yu, James R. Pike, Walter Swardfager, Che‐Yuan Wu, Mario Masellis, Liisa A. M. Galea, Katherine Zukotynski, Gillian Einstein, Sandra E. Black, Lisa L. Barnes, Julie A. Schneider, Zoe Arvanitakis, Kaitlin B. Casaletto, Jennifer S. Rabin   +17 more
wiley   +1 more source

Imaging Atherosclerosis and Vulnerable Plaque [PDF]

Journal of Nuclear Medicine, 2010
Identifying patients at high risk for an acute cardiovascular event such as myocardial infarction or stroke and assessing the total atherosclerotic burden are clinically important. Currently available imaging modalities can delineate vascular wall anatomy and, with novel probes, target biologic processes important in plaque evolution and plaque ...
Lynne L. Johnson, Mehran M. Sadeghi, Gregory M. Lanza, Zahi A. Fayad, David K. Glover   +4 more
openaire   +2 more sources

Harnessing chimeric antigen receptor macrophages against solid tumors

Cancer Communications, EarlyView.
Abstract Macrophages are prevalent in multiple tumors and exhibit diverse and potent functional activities. Therapeutic reprogramming of macrophage phenotypes represents a promising strategy for cancer immunotherapy. Engineering chimeric antigen receptors (CARs) to endow macrophages with anti‐tumor capacities demonstrated encouraging efficacy ...
Mengru Wang, Zhen Qin, Xiu‐Wu Bian, Yu Shi   +3 more
wiley   +1 more source

HDL‐C/LDL‐C Ratio and All‐Cause Mortality in Populations at High CVD Risk: A Prospective Observational Cohort Study

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background The ratio of high‐density lipoprotein cholesterol (HDL‐C) to low‐density lipoprotein cholesterol (LDL‐C) predicts cardiovascular disease (CVD) endpoints, yet its prognostic validity in high‐risk populations and for type 2 diabetes mellitus (T2DM)‐related adverse events remains unestablished. Methods This study included 32,609 people
Biting Lin, Yunzhi Ling, Gengyu Zhou, Ziqing Ruan, Fan Chen, Simiao Chen, Tingting Weng, Yuanfan Zhu, Jingyi Lin, Ling Yu, Kaiyang Lin   +10 more
wiley   +1 more source

4‐Dimethylamino‐1,8‐Naphthalimide as a Fluorescence Signal Amplification for Site Selective and in Situ Probing of the Hydroxyl Radical

Chemistry – A European Journal, EarlyView.
4‐dimethylamino‐1,8‐naphthalimide (NMI) as new fluorescence‐responsive tool for HO• detection. Proof of concept illustrating that NMI selectively probes HO• produced by Cu‐bound to Aβ16 in presence of scavengers with an amplified response. Abstract Overproduction of reactive oxygen species (ROS) is involved in several diseases.
Yelisetty Venkata Suseela, Sabyasachi Mandal, Denis Jacquemin, Thimmaiah Govindaraju, Peter Faller   +4 more
wiley   +1 more source

Serum chemokines combined with multi-modal imaging to evaluate atherosclerotic plaque stability in patients undergoing carotid endarterectomy

Frontiers in Neurology
BackgroundAlthough imaging tools are crucial in identifying features of atherosclerotic plaque, there remains a lack of consensus on the use of serological markers for assessing high-risk plaques.MethodsPatients diagnosed with CAS who met the criteria ...
Xiaofan Yuan, Lei Guo, Hong Chen, Yang Gao, Fuqiang Guo, Jie Huang, Chuan Jiang, Zhenyu Wang   +7 more
doaj   +1 more source

Morphological Features and Plaque Composition in Culprit Atheromatous Plaques of Patients with Acute Coronary Syndromes

Journal of Cardiovascular Emergencies, 2018
Background: The independent role of each plaque feature in relation to plaque vulnerability is still the subject of ongoing research. This study aimed to compare the morphologic characteristics of vulnerable atheromatous coronary plaques with the ones of
Nyulas Tiberiu, Marton Emese, Rus Victoria Ancuta, Rat Nora, Ratiu Mihaela, Benedek Theodora, Benedek Imre   +6 more
doaj   +1 more source

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. [PDF]

, 2019
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Huang, Yadong, Jones, Emily A, Najm, Ramsey   +2 more
core   +1 more source

The interferon-stimulated gene IFITM3 restricts West Nile virus infection and pathogenesis [PDF]

, 2016
The interferon-induced transmembrane protein (IFITM) family of proteins inhibit infection of several different enveloped viruses in cell culture by virtue of their ability to restrict entry and fusion from late endosomes.
Bradbury LE, Chen YX, Ebel GD, Evans SS, Frey M, Omalu BI, Takahashi S   +6 more
core   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source