Results 121 to 130 of about 1,471,775 (278)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Are we ripe for preventive percutaneous coronary interventions?

REC: Interventional Cardiology (English Ed.)
INTRODUCTION Preventive percutaneous coronary intervention (PCI) refers to the treatment of high-risk plaque before the occurrence of any adverse events.
Elvin Kedhi
doaj   +1 more source

Implantable electrochemical sensors for continuous blood monitoring

FlexMat, EarlyView.
Implantable electrochemical sensors enable direct, in situ, and continuous blood monitoring, shifting diagnosis from population‐based averages to dynamic, individualized analysis. This review systematically examines the influence of the unique blood properties on sensor design.
Kuangyi Zou, Yuanzhen Wang, Haidong Wang, Ye Zhang   +3 more
wiley   +1 more source

Flexible wearable electronics for cardiovascular monitoring from surface signals to deep physiological insights

FlexMat, EarlyView.
This review organizes flexible wearable electronics for cardiovascular monitoring into four interconnected information layers: surface electrophysiology, hemodynamic sensing, vascular imaging, and biofluid biomarker analysis. This framework clarifies how electrical rhythm, vascular loading, structural and flow‐related features, and biochemical states ...
Qiao Chen, Hongwen Chen, Yuanyuan Li, Pingan Yang, Rui Li, Zhihao Zhou   +5 more
wiley   +1 more source

SpaceNet: Pathology‐guided analysis of lesion‐associated spatial molecular programs

iMetaOmics, EarlyView.
Disease‐associated molecular alterations are often confined to localized pathological regions, yet current spatial transcriptomic analyses do not always use pathology or imaging information as the primary reference for defining disease‐relevant spatial contexts.
Menglei Wang, Qikun Zhao, Hudong Bao, Kaiyu Jin, Xiaohui Fan, Jie Liao   +5 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Protruding Aortic Plaque and Coronary Plaque Vulnerability

Journal of the American Heart Association
Background Protruding aortic plaque is known to be associated with an increased risk for future cardiac and cerebrovascular events. However, the relationship between protruding aortic plaque and coronary plaque characteristics has not been systematically investigated. Methods and Results
Haruhito Yuki, Eric Isselbacher, Takayuki Niida, Keishi Suzuki, Daisuke Kinoshita, Daichi Fujimoto, Hang Lee, Iris McNulty, Sunao Nakamura, Tsunekazu Kakuta, Ik‐Kyung Jang   +10 more
openaire   +3 more sources

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I.

Circulation, 2003
M. Naghavi, P. Libby, E. Falk, S. Casscells, S. Litovsky, J. Rumberger, J. Badimón, C. Stefanadis, P. Moreno, G. Pasterkamp, Z. Fayad, P. Stone, S. Waxman, P. Raggi, M. Madjid, Alireza Zarrabi, A. Burke, C. Yuan, P. Fitzgerald, D. Siscovick, C. D. de Korte, M. Aikawa, K. E. Juhani Airaksinen, G. Assmann, C. Becker, J. Chesebro, A. Farb, Z. Galis, C. Jackson, I. Jang, W. Koenig, R. Lodder, K. March, J. Demirovic, M. Navab, S. Priori, M. Rekhter, R. Bahr, S. Grundy, R. Mehran, A. Colombo, E. Boerwinkle, C. Ballantyne, W. Insull, R. Schwartz, R. Vogel, P. Serruys, G. Hansson, D. Faxon, S. Kaul, H. Drexler, P. Greenland, J. Muller, R. Virmani, P. Ridker, D. Zipes, P. Shah, J. Willerson   +57 more
semanticscholar   +1 more source