Results 101 to 110 of about 1,471,775 (278)

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Serum chemokines combined with multi-modal imaging to evaluate atherosclerotic plaque stability in patients undergoing carotid endarterectomy

Frontiers in Neurology
BackgroundAlthough imaging tools are crucial in identifying features of atherosclerotic plaque, there remains a lack of consensus on the use of serological markers for assessing high-risk plaques.MethodsPatients diagnosed with CAS who met the criteria ...
Xiaofan Yuan, Lei Guo, Hong Chen, Yang Gao, Fuqiang Guo, Jie Huang, Chuan Jiang, Zhenyu Wang   +7 more
doaj   +1 more source

Morphological Features and Plaque Composition in Culprit Atheromatous Plaques of Patients with Acute Coronary Syndromes

Journal of Cardiovascular Emergencies, 2018
Background: The independent role of each plaque feature in relation to plaque vulnerability is still the subject of ongoing research. This study aimed to compare the morphologic characteristics of vulnerable atheromatous coronary plaques with the ones of
Nyulas Tiberiu, Marton Emese, Rus Victoria Ancuta, Rat Nora, Ratiu Mihaela, Benedek Theodora, Benedek Imre   +6 more
doaj   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability

Therapeutics and Clinical Risk Management, 2021
Xiangli Xu,1 Yang Hua,2 Beibei Liu,2 Fubo Zhou,2 Lili Wang,2 Weihong Hou2 1Department of Ultrasound, the Second Hospital of Harbin, Harbin, People’s Republic of China; 2Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University ...
Xu X, Hua Y, Liu B, Zhou F, Wang L, Hou W   +5 more
doaj  

Serum secreted phosphoprotein 1 level is associated with plaque vulnerability in patients with coronary artery disease

Frontiers in Immunology
BackgroundVulnerable plaque was associated with recurrent cardiovascular events. This study was designed to explore predictive biomarkers of vulnerable plaque in patients with coronary artery disease.MethodsTo reveal the phenotype-associated cell type in
Ke Huang, Ke Huang, Shuai Chen, Shuai Chen, Lin-Jun Yu, Lin-Jun Yu, Zhi-Ming Wu, Zhi-Ming Wu, Qiu-Jing Chen, Xiao-Qun Wang, Xiao-Qun Wang, Fei-Fei Li, Fei-Fei Li, Jing-Meng Liu, Jing-Meng Liu, Yi-Xuan Wang, Yi-Xuan Wang, Lin-Shuang Mao, Lin-Shuang Mao, Wei-Feng Shen, Wei-Feng Shen, Rui-Yan Zhang, Rui-Yan Zhang, Ying Shen, Lin Lu, Lin Lu, Yang Dai, Yang Dai, Feng-Hua Ding, Feng-Hua Ding   +29 more
doaj   +1 more source

Diagnostic potential of TSH to HDL cholesterol ratio in vulnerable carotid plaque identification

Frontiers in Cardiovascular Medicine
ObjectiveThis study aimed to investigate the predictive value of the thyroid-stimulating hormone to high-density lipoprotein cholesterol ratio (THR) in identifying specific vulnerable carotid artery plaques.MethodsIn this retrospective analysis, we ...
Meihua Lei, Shi-Ting Weng, Jun-Jun Wang, Song Qiao   +3 more
doaj   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Cardiovascular and neuropsychiatric outcomes with PCSK9 inhibitors in atherosclerotic cardiovascular disease: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Study design and main findings. After 1:1 propensity score matching, 60 885 PCSK9 inhibitor users and 60 885 statin‐only users with ASCVD were compared. Kaplan–Meier curves show 12‐month cumulative event‐free survival for MACE, psychiatric disease, and neurodegenerative disease.
Tianshu Gu, Yang Chen, Nan Zhang, Uazman Alam, Riccardo Proietti, Tong Liu, Kang‐Yin Chen, Gregory Y. H. Lip   +7 more
wiley   +1 more source