Results 21 to 30 of about 33,525 (258)

Automated diagnosis of optical coherence tomography imaging on plaque vulnerability and its relation to clinical outcomes in coronary artery disease

Scientific Reports, 2022
This study sought to develop a deep learning-based diagnostic algorithm for plaque vulnerability by analyzing intravascular optical coherence tomography (OCT) images and to investigate the relation between AI-plaque vulnerability and clinical outcomes in
Hirohiko Niioka, Teruyoshi Kume, Takashi Kubo, Tsunenari Soeda, Makoto Watanabe, Ryotaro Yamada, Yasushi Sakata, Yoshihiro Miyamoto, Bowen Wang, Hajime Nagahara, Jun Miyake, Takashi Akasaka, Yoshihiko Saito, Shiro Uemura   +13 more
doaj   +1 more source

Coronary Computed Tomography Angiography Analysis of Calcium Content to Identify Non-culprit Vulnerable Plaques in Patients With Acute Coronary Syndrome

Frontiers in Cardiovascular Medicine, 2022
BackgroundAside from the culprit plaque, the presence of vulnerable plaques in patients with acute coronary syndrome (ACS) may be associated with future cardiac events.
Théo Pezel, Théo Pezel, Georgios Sideris, Jean-Guillaume Dillinger, Damien Logeart, Stéphane Manzo-Silberman, Alain Cohen-Solal, Florence Beauvais, Niveditha Devasenapathy, Jean-Pierre Laissy, Patrick Henry   +10 more
doaj   +1 more source

Single-cell atlas reveals different immune environments between stable and vulnerable atherosclerotic plaques

Frontiers in Immunology, 2023
IntroductionRegardless of the degree of stenosis, vulnerable plaque is an important cause of ischemic stroke and thrombotic complications. The changes of the immune microenvironment within plaques seem to be an important factor affecting the ...
Peicong Ge, Peicong Ge, Hao Li, Hao Li, Xiaolong Ya, Xiaolong Ya, Yiqiao Xu, Long Ma, Long Ma, Qiheng He, Qiheng He, Rong Wang, Rong Wang, Zechen Liu, Qian Zhang, Qian Zhang, Yan Zhang, Yan Zhang, Wenjing Wang, Dong Zhang, Dong Zhang, Dong Zhang, Jizong Zhao, Jizong Zhao   +23 more
doaj   +1 more source

Folate Receptor–Targeted Single-Photon Emission Computed Tomography/Computed Tomography to Detect Activated Macrophages in Atherosclerosis: Can It Distinguish Vulnerable from Stable Atherosclerotic Plaques?

Molecular Imaging, 2014
The need for noninvasive imaging to distinguish stable from vulnerable atherosclerotic plaques is evident. Activated macrophages play a role in atherosclerosis and express folate receptor folate receptor β (FR-β).
Leah C.J. Winkel, Harald C. Groen, Bibi S. van Thiel, Cristina Müller, Antonius F.W. van der Steen, Jolanda J. Wentzel, Marion de Jong, Kim Van der Heiden   +7 more
doaj   +1 more source

Geographical predisposition influences on the distribution and tissue characterisation of eccentric coronary plaques in non-branching coronary arteries: cross-sectional study of coronary plaques analysed by intravascular ultrasound

Cardiovascular Ultrasound, 2016
Background We investigated the influence of geographical predisposition on the spatial distribution and composition of coronary plaques. Methods Thirty coronary arteries were evaluated.
Hidenori Komiyama, Hitoshi Takano, Shunichi Nakamura, Masamichi Takano, Noritake Hata, Miyauchi Yasushi, Yoshihiko Seino, Kyoichi Mizuno, Wataru Shimizu   +8 more
doaj   +1 more source

Comparison of multilayer and single-layer coronary plaque models on stress/strain calculations based on optical coherence tomography images

Frontiers in Physiology, 2023
Mechanical stress and strain conditions are closely related to atherosclerotic plaque progression and rupture and have been under intensive investigations in recent years.
Mengde Huang, Akiko Maehara, Dalin Tang, Dalin Tang, Jian Zhu, Liang Wang, Rui Lv, Yanwen Zhu, Xiaoguo Zhang, Mitsuaki Matsumura, Lijuan Chen, Genshan Ma, Gary S. Mintz   +12 more
doaj   +1 more source

The Use of Biomarkers for the Early Detection of Vulnerable Atherosclerotic Plaques and Vulnerable Patients. A Review

Journal of Cardiovascular Emergencies, 2016
Acute coronary syndromes represent the most severe consequences of atherosclerosis, most often triggered by the rupture of a coronary plaque, which, for various reasons, has become unstable.
Benedek Theodora, Maurovich-Horváth Pál, Ferdinandy Péter, Merkely Béla   +3 more
doaj   +1 more source

Optical imaging techniques for vulnerable plaque detection

Translational Biophotonics, 2020
Vulnerable plaque rupture is the most important cause of myocardial infarction and acute coronary syndrome. Therefore, identifying vulnerable plaques is of prime importance, which will in turn aid in the development of treatments to stabilise them ...
Suleiman Eldomi, Junaid Zafar, Ritasree Sengupta, Faisal Sharif, Haroon Zafar   +4 more
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Sex-specific association between inflammation and endothelial function relevant gene and vulnerable carotid plaque

Frontiers in Physiology, 2022
Objectives: We aimed to explore sex-specific association between genes involved in inflammation and endothelial function and vulnerable carotid plaque, a subclinical precursor of ischemic stroke.Methods: Carotid plaque and plaque phenotype were assessed ...
Jie Li, Ping Zhang, Xingyang Yi, Hua Luo, Ming Yu, Hong Chen, Chun Wang   +6 more
doaj   +1 more source