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Imaging Carotid Atherosclerosis Plaque Ulceration: Comparison of Advanced Imaging Modalities and Recent Developments. [PDF]
, 2016 Atherosclerosis remains the leading cause of long-term mortality and morbidity worldwide, despite remarkable advancement in its management. Vulnerable atherosclerotic plaques are principally responsible for thromboembolic events in various arterial ...
Das, T +5 more
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Multitarget Vulnerable Plaque Imaging [PDF]
Circulation: Cardiovascular Imaging, 2017 The search for the vulnerable plaque has been a prolonged, circuitous journey that despite considerable investment and resource expenditure has hitherto failed to alter clinical practice. The rationale remains enticing. We have known for some time that plaques at risk of rupture and precipitating myocardial infarction and stroke have certain ...
Marc R, Dweck, Zahi A, Fayad
openaire +2 more sources
Journal of Cardiovascular Emergencies, 2016 Acute coronary syndromes represent the most severe consequences of atherosclerosis, most often triggered by the rupture of a coronary plaque, which, for various reasons, has become unstable.
Benedek Theodora +3 more
doaj +1 more source
Requiem for the ‘vulnerable plaque’ [PDF]
European Heart Journal, 2015 The concept of the so-called ‘vulnerable plaque’ has proved highly useful to guide research and thinking regarding the pathophysiology of the acute coronary syndromes (ACS). Yet, the time may have come to reconsider this construct, as knowledge has accumulated, the risk profile of the populace has shifted, and our current therapies have reshaped the ...
Libby, Peter, Pasterkamp, Gerard
openaire +4 more sources
The complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis [PDF]
, 2016 Inflammation and neovascularization in vulnerable atherosclerotic plaques are key features for severe clinical events. Dynamic contrast-enhanced (DCE) MRI and FDG PET are two noninvasive imaging techniques capable of quantifying plaque neovascularization
Bucerius, Jan +18 more
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Neuroimaging of the Vulnerable Plaque [PDF]
Current Vascular Pharmacology, 2015 Plaque vulnerability due to inflammation has been shown to be a participating factor in the degenerative process in the arterial wall that contributes to stenosis and embolism. This is believed to have an important role to play also in the genesis of stroke or cerebrovascular diseases.
Lövblad, Karl-Olof +7 more
openaire +3 more sources
Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]
, 2011 Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Amento +91 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang +8 more
wiley +1 more source
Frontiers in Physiology, 2022 Objectives: We aimed to explore sex-specific association between genes involved in inflammation and endothelial function and vulnerable carotid plaque, a subclinical precursor of ischemic stroke.Methods: Carotid plaque and plaque phenotype were assessed ...
Jie Li +6 more
doaj +1 more source
Mathematical models for vulnerable plaques [PDF]
, 2009 A plaque is an accumulation and swelling in the artery walls and typically consists of cells, cell debris, lipids, calcium deposits and fibrous connective tissue.
Bell, J. +10 more
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