Results 41 to 50 of about 33,556 (247)

Sex-specific association between inflammation and endothelial function relevant gene and vulnerable carotid plaque

Frontiers in Physiology, 2022
Objectives: We aimed to explore sex-specific association between genes involved in inflammation and endothelial function and vulnerable carotid plaque, a subclinical precursor of ischemic stroke.Methods: Carotid plaque and plaque phenotype were assessed ...
Jie Li, Ping Zhang, Xingyang Yi, Hua Luo, Ming Yu, Hong Chen, Chun Wang   +6 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Ultrasound lmaging-vulnerable plaque diagnostics: Automatic carotid plaque segmentation based on deep learning

Journal of Radiation Research and Applied Sciences, 2023
Purpose: The purpose of this article is to develop a novel algorithm based on a kind of deep convolutional neural network for the automatic carotid plaque segmentation and stroke risk assessment from the carotid artery plaque using Doppler ultrasound ...
Xiao-xiao Chen, Zi-xiang Kong, Shu-fang Wei, Fei Liang, Ting Feng, Shan-shan Wang, Jian-song Gao   +6 more
doaj   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

The Impact of Coronary Artery Calcification on Long-Term Cardiovascular Outcomes

Journal of Interdisciplinary Medicine, 2021
Decades of research and experimental studies have investigated various strategies to prevent acute coronary events. However, significantly efficient preventive methods have not been developed and still remains a challenge to determine if a coronary ...
Mitra Noémi, Gerculy Renáta, Szabó Evelin, Opincariu Diana, Chițu Monica, Benedek Imre   +5 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Increased macrophage activity in coronary plaques in patients with acute coronary syndrome and familial hypercholesterolemia

International Journal of Cardiology. Cardiovascular Risk and Prevention
Background: Patients with familial hypercholesterolemia (FH) experience acute coronary syndrome (ACS) at a younger age and have a higher risk of recurrent coronary events. The study aimed to elucidate the morphological characteristics of coronary plaques
Toshiyuki Iwaya, Yoshiyasu Minami, Kiyoshi Asakura, Takako Nagata, Masahiro Katamine, Takuya Hashimoto, Junya Ako   +6 more
doaj   +1 more source

Ligation of macrophage Fcγ receptors recapitulates the gene expression pattern of vulnerable human carotid plaques. [PDF]

PLoS ONE, 2011
Stroke is a leading cause of death in the United States. As ∼60% of strokes result from carotid plaque rupture, elucidating the mechanisms that underlie vulnerability is critical for therapeutic intervention.
Michelle R Lennartz, Ankur Aggarwal, Tanya M Michaud, Paul J Feustel, David M Jones, M Julia Brosnan, Rebecca S Keller, Daniel J Loegering, Paul B Kreienberg   +8 more
doaj   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source