Results 21 to 30 of about 33,280 (247)

Inflammation and plaque vulnerability [PDF]

Journal of Internal Medicine, 2015
AbstractAtherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs at sites of blood flow disturbance. The disease usually remains silent until a breakdown of integrity at the arterial surface triggers the formation of a thrombus.
Hansson, Goran, Libby, Peter, Tabas, Ira
openaire   +4 more sources

Requiem for the ‘vulnerable plaque’ [PDF]

European Heart Journal, 2015
The concept of the so-called ‘vulnerable plaque’ has proved highly useful to guide research and thinking regarding the pathophysiology of the acute coronary syndromes (ACS). Yet, the time may have come to reconsider this construct, as knowledge has accumulated, the risk profile of the populace has shifted, and our current therapies have reshaped the ...
Libby, Peter, Pasterkamp, Gerard
openaire   +4 more sources

High systemic immune-inflammation index is associated with carotid plaque vulnerability: New findings based on carotid ultrasound imaging in patients with acute ischemic stroke

Frontiers in Neurology, 2022
Vulnerable carotid plaque is closely related to the occurrence of Ischemic stroke. Therefore, accurate and rapid identification of the nature of carotid plaques is essential. AS is a chronic immune inflammatory process. Systemic immune-inflammation index
Lianlian Zhang, Qi Lyu, Wenyan Zhou, Xia Li, Qinggan Ni, Shu Jiang, Guofu Shi   +6 more
doaj   +1 more source

Plaque regression and plaque stabilisation in cardiovascular diseases

Indian Journal of Endocrinology and Metabolism, 2013
Atherosclerosis is characterized by formation of plaques on the inner walls of arteries that threatens to become the leading cause of death worldwide via its sequelae of myocardial infarction and stroke.
Tarun Dave, J Ezhilan, Hardik Vasnawala, Vinod Somani   +3 more
doaj   +1 more source

Autoradiographical assessment of inflammation-targeting radioligands for atherosclerosis imaging: potential for plaque phenotype identification

EJNMMI Research, 2021
Purpose Many radioligands have been developed for the visualization of atherosclerosis by targeting inflammation. However, interpretation of in vivo signals is often limited to plaque identification. We evaluated binding of some promising radioligands in
Eric J. Meester, Erik de Blois, Boudewijn J. Krenning, Antonius F. W. van der Steen, Jeff P. Norenberg, Kim van Gaalen, Monique R. Bernsen, Marion de Jong, Kim van der Heiden   +8 more
doaj   +1 more source

Automated diagnosis of optical coherence tomography imaging on plaque vulnerability and its relation to clinical outcomes in coronary artery disease

Scientific Reports, 2022
This study sought to develop a deep learning-based diagnostic algorithm for plaque vulnerability by analyzing intravascular optical coherence tomography (OCT) images and to investigate the relation between AI-plaque vulnerability and clinical outcomes in
Hirohiko Niioka, Teruyoshi Kume, Takashi Kubo, Tsunenari Soeda, Makoto Watanabe, Ryotaro Yamada, Yasushi Sakata, Yoshihiro Miyamoto, Bowen Wang, Hajime Nagahara, Jun Miyake, Takashi Akasaka, Yoshihiko Saito, Shiro Uemura   +13 more
doaj   +1 more source

Pathology of the Vulnerable Plaque

Journal of the American College of Cardiology, 2006
The majority of patients with acute coronary syndromes (ACS) present with unstable angina, acute myocardial infarction, and sudden coronary death. The most common cause of coronary thrombosis is plaque rupture followed by plaque erosion, whereas calcified nodule is infrequent.
Virmani, Renu, Burke, Allen P., Farb, Andrew, Kolodgie, Frank D.   +3 more
openaire   +2 more sources

Coronary Computed Tomography Angiography Analysis of Calcium Content to Identify Non-culprit Vulnerable Plaques in Patients With Acute Coronary Syndrome

Frontiers in Cardiovascular Medicine, 2022
BackgroundAside from the culprit plaque, the presence of vulnerable plaques in patients with acute coronary syndrome (ACS) may be associated with future cardiac events.
Théo Pezel, Théo Pezel, Georgios Sideris, Jean-Guillaume Dillinger, Damien Logeart, Stéphane Manzo-Silberman, Alain Cohen-Solal, Florence Beauvais, Niveditha Devasenapathy, Jean-Pierre Laissy, Patrick Henry   +10 more
doaj   +1 more source

In Search of Vulnerable Plaque [PDF]

Circulation: Cardiovascular Imaging, 2012
Between 1970 and 2010, the number of cardiovascular deaths per 100 000 persons in the United States has fallen from ≈450 to ≈125, a reduction >70%.1 This marked decline in cardiovascular mortality represents one of the true success stories of modern medicine.
openaire   +2 more sources

Folate Receptor–Targeted Single-Photon Emission Computed Tomography/Computed Tomography to Detect Activated Macrophages in Atherosclerosis: Can It Distinguish Vulnerable from Stable Atherosclerotic Plaques?

Molecular Imaging, 2014
The need for noninvasive imaging to distinguish stable from vulnerable atherosclerotic plaques is evident. Activated macrophages play a role in atherosclerosis and express folate receptor folate receptor β (FR-β).
Leah C.J. Winkel, Harald C. Groen, Bibi S. van Thiel, Cristina Müller, Antonius F.W. van der Steen, Jolanda J. Wentzel, Marion de Jong, Kim Van der Heiden   +7 more
doaj   +1 more source