Clinical risk factors and atherosclerotic plaque extent to define risk for major events in patients without obstructive coronary artery disease: the long-term coronary computed tomography angiography CONFIRM registry. [PDF]
, 2020 AimsIn patients without obstructive coronary artery disease (CAD), we examined the prognostic value of risk factors and atherosclerotic extent.Methods and resultsPatients from the long-term CONFIRM registry without prior CAD and without obstructive (≥50%)
Achenbach, Stephan +37 more
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Vulnerable Plaque Inside Stent
JACC: Cardiovascular Imaging, 2011 it has been proposed that nonhealing endothelium after percutaneous coronary intervention may allow for insudation of lipids superficial to the stent strut level, especially when the underlying plaque carried a large necrotic core.
Il Suk Sohn +3 more
openaire +3 more sources
Cytokine Engineering Approaches for Regenerative Medicine
Advanced Therapeutics, EarlyView.Engineered cytokines represent a powerful strategy to promote tissue repair and regeneration by precisely modulating immune responses. This review highlights recent advances in cytokine engineering, including strategies to enhance half‐life, improve tissue and cell targeting, and control receptor signaling.
Shiyi Li, Wenhao You, Mikaël M. Martino
wiley +1 more source
Porphyromonas gingivalis periodontal infection and its putative links with Alzheimer’s disease [PDF]
, 2015 Periodontal disease (PD) and Alzheimer’s disease (AD) are inflammatory conditions affecting the global adult population. In the pathogenesis of PD, subgingival complex bacterial biofilm induces inflammation that leads to connective tissue degradation and
Crean, Stjohn +4 more
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Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1
Advanced Science, EarlyView.The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo +10 more
wiley +1 more source
Vulnerable Carotid Artery Plaques in Asymptomatic Patients—A Narrative Review
The Arab Journal of Interventional Radiology, 2022 Over the last two decades, medical management of carotid artery patients has improved significantly. Most patients remain stable on best medical therapy (BMT), making interventions unnecessary in all patients.
Zia Ur Rehman
doaj +1 more source
Pharmacologic approaches against advanced glycation end products (ages) in diabetic cardiovascular disease [PDF]
, 2015 Advanced Glycation End-Products (AGEs) are signaling proteins associated to several vascular and neurological complications in diabetic and non-diabetic patients.
Avtaar Singh, Sanjeet Singh +6 more
core +2 more sources
MSCT Identification of Vulnerable Plaque
JACC: Cardiovascular Imaging, 2016 Acute myocardial infarction and sudden cardiac death are the first manifestations of coronary artery disease in most patients. Identifying patients at high risk for developing acute coronary syndromes (ACS) is a major challenge for contemporary cardiovascular imaging.
Alexandre Abizaid +6 more
openaire +3 more sources
Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis
Advanced Science, EarlyView.Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves +17 more
wiley +1 more source
Comparison of multidetector-row computed tomography and duplex Doppler ultrasonography in detecting atherosclerotic carotid plaques complicated with intraplaque hemorrhage [Usporedba višeslojne kompjuterizirane tomografije i duplex Doppler ultrazvuka u otkrivanju aterosklerotskih karotidnih plakova kompliciranih krvarenjem u plak ] [PDF]
, 2013 This study compared sensitivity and specificity of multidetector-row computed tomography and duplex Doppler ultrasonography in detecting atherosclerotic carotid plaques complicated with intraplaque hemorrhage.
Ajduk, Marko +8 more
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