Results 191 to 200 of about 1,043,722 (370)

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Advancements in Bio‐Integrated Flexible Electronics for Hemodynamic Monitoring in Cardiovascular Healthcare

Advanced Science, EarlyView.
This review explores the cutting‐edge development of bio‐integrated flexible electronics for real‐time hemodynamic monitoring in cardiovascular healthcare. It covers key physiological indicators, innovative sensing mechanisms, and materials considerations. This paper highlights the application of both invasive and non‐invasive devices in cardiovascular
Ke Huang, Zhiqiang Ma, Bee Luan Khoo
wiley   +1 more source

Chromosome‐Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology

Advanced Science, EarlyView.
The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi, Pan Duan, Mengmeng Zhu, Rong Zhang, Zihua Zhao, Xin Nie, Hanhou He, Li Hou, Xianhui Wang   +8 more
wiley   +1 more source

Smart Contract Vulnerability Detection based on Static Analysis and Multi-Objective Search [PDF]

arXiv
This paper introduces a method for detecting vulnerabilities in smart contracts using static analysis and a multi-objective optimization algorithm. We focus on four types of vulnerabilities: reentrancy, call stack overflow, integer overflow, and timestamp dependencies.
arxiv  

Social Science Research Needs: Focus on Vulnerable Populations, Forecasting, and Warnings [PDF]

, 2007
Brenda D. Phillips, Betty Hearn Morrow
openalex   +1 more source

Health of Vulnerable Populations

Academic Medicine, 2018
Peter S. Spencer, Valerie S. Palmer, Kathleen I. Birchfield   +2 more
openaire   +4 more sources

Manipulating Charge Dynamics in Carbon Nitride by Carbon Dot Doping for Efficient Photocatalysis

Advanced Science, EarlyView.
A series of carbon dot (CD) doped graphitic carbon nitride (g‐C3N4) materials have been rationally synthesized, which exhibited different photophysical properties, excitonic behaviors, and photocatalytic degradation activities. It provides valuable insights to deepen the understanding of exciton dynamics based on g‐C3N4 materials, and rational design ...
Lingfeng Ouyang, Maggie Ng, Zhang‐Hong Zhou, Hao Wu, Man‐Chung Tang, Season Si Chen   +5 more
wiley   +1 more source

Obesity and Diabetes in Vulnerable Populations: Reflection on Proximal and Distal Causes [PDF]

, 2007
Lucy M. Candib
openalex   +1 more source

Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management

Advanced Science, EarlyView.
Electroactive platforms offer promising applications in cardiac arrhythmia. Based on their energy sources and mechanisms, electroactive platforms are categorized into i) direct electrical stimulation, ii) self‐powered electroactive systems, iii) physical stimuli‐mediated electroactive systems, and iv) conductive systems, and their applications in ...
Juwei Yang, Longfei Li, Yiran Hu, Zhou Li, Wei Hua   +4 more
wiley   +1 more source

Access to Care Among Vulnerable Populations Enrolled in Commercial HMOs

, 2003
Matthew J. Carlson, Jan Blustein
openalex   +2 more sources