Results 151 to 160 of about 234,309 (195)

Specific intraepithelial localization of mast cells in differentiated vulvar intraepithelial neoplasia and its possible contribution to vulvar squamous cell carcinoma development [PDF]

Histopathology, 2010
Contains fulltext : 89197.pdf (Publisher’s version ) (Open Access)AIMS: The aetiology of vulvar squamous cell carcinomas (SCC) that are not causally associated with high-risk human papillomavirus remains largely elusive. The aim of this
Leon F A G Massuger, Johan Bulten, Léon C van Kempen   +2 more
exaly   +4 more sources

Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma [PDF]

Modern Pathology, 2010
Differentiated vulvar intraepithelial neoplasia is a unique precursor to vulvar squamous cell carcinoma that is typically HPV-negative and frequently associated with nuclear p53 staining. These features imply a mode of pathogenesis involving somatic mutations.
Christopher P Crum, Alvaro P Pinto, Alexander Miron   +2 more
exaly   +3 more sources

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Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma

Histopathology, 2012
Vulvar squamous cell carcinoma (VSCC) accounts for >90% of the malignant tumours of the vulva. Most VSCCs originate in intraepithelial lesions, named vulvar intraepithelial neoplasia (VIN), that precede the development of VSCC by a variable period of time.
Marta, Del Pino, Leonardo, Rodriguez-Carunchio, Jaume, Ordi   +2 more
openaire   +2 more sources

Reproducibility of the Histopathological Classification of Vulvar Squamous Carcinoma and Intraepithelial Neoplasia

Journal of Lower Genital Tract Disease, 1999
Invasive vulvar carcinoma has been shown to be etiologically heterogeneous on the basis of pathological, virological, and epidemiological criteria. Human papillomavirus-related invasive vulvar carcinoma has basaloid or warty morphology and has adjacent basaloid or warty intraepithelial neoplasia.
C L, Trimble, M, Diener-West, E J, Wilkinson, R J, Zaino, R J, Kurman, K V, Shah   +5 more
openaire   +2 more sources

Squamous Vulvar Intraepithelial Neoplasia: 2004 Modified Terminology, ISSVD Vulvar Oncology Subcommittee

Obstetrical & Gynecological Survey, 2006
In the current classification, squamous vulvar intraepithelial neoplasia (VIN) is categorized as VIN 1, 2 and 3 according to the degree of abnormality. There is neither evidence that the VIN 1-3 morphologic spectrum reflects a biologic continuum nor that VIN 1 is a cancer precursor.
Sideri, Mario, Jones, Ronald W, Wilkinson, Edward J, Preti, Mario, Heller, Debra S, Scurry, James, Haefner, Hope, Neill, Sallie   +7 more
openaire   +3 more sources

Immunohistochemical Expression of SOX2 in Vulvar Intraepithelial Neoplasia and Squamous Cell Carcinoma

International Journal of Gynecological Pathology, 2013
SOX2 is a transcription factor controlling pluripotency in both embryonic stem cells and adult tissue-specific stem cells. SOX2 has been reported as an important factor in squamous cell carcinomas (SCC) of different locations and is involved in tumorigenesis.
Hermann, Brustmann, Andreas, Brunner
openaire   +2 more sources

Trends in Squamous Cell Carcinoma of the Vulva: The Influence of Vulvar Intraepithelial Neoplasia

Obstetrics & Gynecology, 1997
To determine trends in the clinicopathology of vulvar squamous cell carcinoma over the past 2 decades, with particular reference to the possible effects of the increasing incidence of vulvar intraepithelial neoplasia (VIN) during this time.Two cohorts of 56 and 57 women with squamous cell carcinoma of the vulva and separated by at least 2 decades were ...
R W, Jones, J, Baranyai, S, Stables
openaire   +2 more sources

Serum concentrations of squamous cell carcinoma antigen in patients with vulvar intraepithelial neoplasia and vulvar cancer

International Journal of Cancer, 1999
Our aim was to evaluate whether serum concentrations of squamous cell carcinoma antigen (SCC-Ag) are an independent prognostic factor in patients with vulvar cancer. We measured SCC-Ag in pretreatment serum samples of 55 patients with squamous cell vulvar cancer, 30 patients with vulvar intraepithelial neoplasia (VIN) grade III and 50 healthy female ...
Hefler, L, Obermair, A, Tempfer, C, van Houte, M, Maenner, G, Reinthaller, A, Leodolter, S, Kainz, C   +7 more
openaire   +4 more sources

Trends in Vulvar Neoplasia:

Obstetric and Gynecologic Survey, 2001
To determine trends in the epidemiology of vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma (SCC) of the vulva in a Central European sample during the last decade.A total of 366 women with VIN 2 and 3 (n = 128) or vulvar SCC (n = 238) presented within two four-year periods separated by one decade (1985-1988 and 1994-1997).
E A, Joura, A, Lösch, M G, Haider-Angeler, G, Breitenecker, S, Leodolter   +4 more
openaire   +2 more sources

Downregulated CD44 and hyaluronan expression in vulvar intraepithelial neoplasia and squamous cell carcinomas

Acta Obstetricia et Gynecologica Scandinavica, 2010
AbstractObjective. To investigate the expression of CD44 and hyaluronan in vulvar squamous cell carcinomas, vulvar intraepithelial neoplasia (VIN) and lichen sclerosus (LS) cases. Design. Retrospective study. Setting. Kuopio University Hospital in Finland. Samples and methods.
Kirsi, Hämäläinen, Veli-Matti, Kosma, Marja-Liisa, Eloranta, Raija, Tammi, Markku, Tammi, Marjo, Leppänen, Merja, Leppänen, Seppo, Heinonen, Maarit, Anttila   +8 more
openaire   +2 more sources