Results 61 to 70 of about 234,309 (195)

High-Grade Vaginal Intraepithelial Neoplasia: Clinical Profile, HPV Vaccination Status, and Treatment Outcomes at Two Italian Referral Centers

Vaccines
Background: There is limited available data about the natural history and clinical characteristics of patients affected by high-grade vaginal intraepithelial neoplasia (or vaginal intraepithelial neoplasia 2/3 or vaginal high-grade squamous ...
Niccolò Gallio, Mario Preti, Renzo Boldorini, Cristina Cavagnetto, Fulvio Borella, Federica Bevilacqua, Ilaria Barbierato, Raffaella Ribaldone, Enrica Bovio, Chiara Airoldi, Valentino Remorgida, Luca Marozio, Alberto Revelli   +12 more
doaj   +1 more source

Analysis of Age, Period and Cohort Trends in Cervical In Situ and Invasive Carcinomas for Assessing the Utility of Screening Approaches—Results From the Saarland Cancer Registry

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background Cervical cancer continues to pose a significant public health burden. In Germany, prevention relies heavily on regular screening and HPV vaccination. Objective To analyze trends in cervical cancer incidence over a 50‐year period in Saarland, Germany, with a focus on cohort effects and the impact of screening programs.
Natalie Rath, Klaus Neis, Bernd Holleczek   +2 more
wiley   +1 more source

The challenges of managing vulval squamous cell cancer in women with Fanconi anaemia: A case report and literature review

Case Reports in Women's Health
Women with Fanconi anaemia are predisposed to developing squamous cell carcinoma in the lower genital tract at a very young age due to inherent defects in their DNA repair mechanisms.
Chester Chiah, Lucy Grant, Jason Yap, Fong Lien Kwong   +3 more
doaj   +1 more source

GATA3 Inhibits the Expression of Viral E6/E7 Genes, and Its Expression Is Compromised During HPV‐Mediated Cervical Carcinogenesis

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT High‐risk human papillomaviruses (HPV) are the main etiological agents of cervical cancer. The viral early promoter regulates the expression of E6/E7 oncoproteins, and its transcriptional activity is positively or negatively regulated by host transcription factors (TFs) that are able to bind to the viral long control region (LCR).
Valéria Talpe‐Nunes, Aline Lopes Ribeiro, Rafaella Almeida Nunes, João Simão Sobrinho, Amanda Schiersner Caodaglio, Rossana Veronica Mendonza Lopez, Thais Rocha, Maria Luiza Nogueira Dias Genta, Konstanze Schichl, Ademola Aiyenuro, John Doorbar, Laura Sichero   +11 more
wiley   +1 more source

Two Distinct Pathways to Development of Squamous Cell Carcinoma of the Vulva

Journal of Skin Cancer, 2011
Squamous cell carcinoma (SCC) accounts for approximately 95% of the malignant tumors of the vaginal vulva and is mostly found in elderly women. The future numbers of patients with vulvar SCC is expected to rise, mainly because of the proportional ...
Yutaka Ueda, Takayuki Enomoto, Toshihiro Kimura, Kiyoshi Yoshino, Masami Fujita, Tadashi Kimura   +5 more
doaj   +1 more source

Prognostic impact of anal cancer morphology on survival and local recurrence: A 20‐year regional cohort study

Colorectal Disease, Volume 28, Issue 7, July 2026.
Abstract Aim The relationship between macroscopic tumour morphology and clinical outcomes has previously been demonstrated for malignant melanoma and gastric cancers, but not for anal squamous cell cancer (ASCC). This study investigated the effect of the morphology of ASCC on oncological outcomes.
Alwin Puthiyakunnel Saji, Thomas Rackley, James Horwood, Rachel Hargest   +3 more
wiley   +1 more source

Vulvar intraepithelial neoplasia [PDF]

, 2003
In order to improve the timely diagnostics and the efficacy of treatment of vulvar intraepithelial neoplasia, vulvar intraepithelial neoplasia diagnostics criteria and the modern treatment strategies are discussed in this review.
Čigriejienė, Vida Marija, Žilinskas, Kastytis, Sakalienė, Jurgita   +2 more
core  

Assessing General Practitioners' Confidence in Undertaking Assessment and Ongoing Management of Patients With Diagnosed, Stable Vulval Lichen Sclerosus (VLS): Laying the Foundation for a Shared‐Care Model

Australasian Journal of Dermatology, Volume 67, Issue 4, Page e239-e247, June 2026.
ABSTRACT Background Vulval Lichen Sclerosus (VLS) is a chronic inflammatory condition requiring lifelong management to prevent severe complications including malignancy. A shared care model between general practitioners (GPs) and public non‐GP specialists (dermatologist or gynaecologist) for patients with stable LS would alleviate the demand on public ...
Arav Kannen, Carolyn Marlow, Suzanne Edwards, Arabella Wallett   +3 more
wiley   +1 more source

Anal Cancer Screening and High‐Resolution Anoscopy: What Surgeons Should Know

ANZ Journal of Surgery, Volume 96, Issue 9, Page 2671-2678, September 2026.
Matthew Joseph Marino, Benedict Blacket, Richard Clive Turner, Tamzin Cuming, David R. C. James   +4 more
wiley   +1 more source

methylation markers for cancer risk prediction of vulvar intraepithelial neoplasia

, 2021
Current clinical and histological classifications are unable to determine the risk of vulvar squamous cell carcinoma (VSCC) in high-grade vulvar intraepithelial neoplasia (VIN), making prognostic biomarkers highly needed.
Steenbergen, Renske D. M., Thuijs, Nikki B., Duin, Sylvia, Barbara C. Snoek, Renske D. M. Steenbergen, Nikki B. Thuijs, Müjde Özer, Heideman, Danielle A. M., Daniëlle A. M. Heideman, Ozer, Mujde, van Beurden, Marc, van Splunter, Annina P., Sylvia Duin, Annina P. van Splunter, Maaike C. G. Bleeker, Marc van Beurden, Berkhof, Johannes, Özer, M. jde, Bleeker, Maaike C. G., Snoek, Barbara C., Johannes Berkhof   +20 more
core   +1 more source