Results 211 to 220 of about 61,670 (295)

Prognostic value of von Willebrand factor and ADAMTS-13 in patients with sepsis-induced coagulopathy. [PDF]

Res Pract Thromb Haemost
Zhang F, Li Y, Li Y, Zhang D.
europepmc   +1 more source

Lung‐Cardiovascular Interactions and Derangements in ARDS

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
This review proposes an anatomical near‐ and far‐field framework for lung‐cardiovascular interactions in ARDS. Grounded in pathological and biological studies, the evidence spans pulmonary vascular, right ventricular, and systemic endothelial derangements and reviews available evidence for targeted therapies.
Pablo A. Sanchez, Connor O'Brien, Matthieu Legrand, Carolyn S. Calfee, Michael A. Matthay   +4 more
wiley   +1 more source

Factor VIII inhibitors demonstrate type I or type II kinetics in high‐titre alloantibodies and autoantibodies

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
The inhibitor kinetics type cannot be used by itself to determine auto‐ versus allo‐anti‐FVIII antibody type. To characterise inhibitor kinetics in inherited haemophilia A (HA) and acquired haemophilia A (AHA) patients in our centre, results show that inhibitors for both HA alloantibodies and AHA autoantibodies may exhibit either type I or type II ...
Cuicui Qiao, Jie Wang, Tiantian Wang, Hehe Wang, Yingfang Pan, Wei Liu, Yan Cheng, Feng Xue, Man‐Chiu Poon, Xinsheng Zhang, Yunhai Fang   +10 more
wiley   +1 more source

Dual hemostatic defects in Glanzmann thrombasthenia and von Willebrand disease: functional characterization of ITGA2B and dominant-negative von Willebrand factor variants. [PDF]

Res Pract Thromb Haemost
Zhang Y, Shima T, Yamanaka I, Ueda S, Nishida A, Ohga S, Morodomi Y, Numata A, Eto T, Kanaji T, Okamura T, Kato K, Akashi K, Kunisaki Y, Kanaji S.   +14 more
europepmc   +1 more source

Von Willebrand, factor VIII, and D-dimer levels as predictors of risk and clinical outcomes in acute myeloid leukemia. [PDF]

Clin Exp Med
El-Sayed HA, Sakr DH, Ebrahim MA, Alghandour R, Eid E, Denewer M, Saarsalu B, Othman M, Azzam H.   +8 more
europepmc   +1 more source

Multi‐omics integration and machine learning identify an ACKR1+ endothelial cell‐based lactate‐immune signature associated with carotid plaque vulnerability and progression

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
ACKR1+ endothelial cells mark intraplaque neovessels with hyperactive glycolysis and lactate metabolism. Lactate, HIF‐1α and CXCL12 link this state to CXCR4+ CD8+ T‐cell recruitment in situ. SLC16A3 and SLC16A4 serve as quantitative readouts of this lactate–immune state.
Ji Zhang, Qijian Zhao, Yufei Wu, Keqiang Shu, Junye Chen, Kang Li, Yuyao Feng, Xu Zhang, Wenjian Liu, Zhichao Lai, Bao Liu   +10 more
wiley   +1 more source

Identification of von Willebrand Factor-Enriched Small Extracellular Vesicles as a Blood-Based Biomarker for the Detection of Head and Neck Squamous Cell Carcinoma. [PDF]

Cancers (Basel)
Su Y, Visan KS, Ham S, Li X, Park SH, Ng CWK, Yam JWP, Chan JYK, Möller A.   +8 more
europepmc   +1 more source

Neuro‐associated SEMA3C+ tumour cells promote gastric cancer peritoneal metastasis via EBF2–FGF7–FGFR2‐mediated tumour–endothelial crosstalk

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Single‐nucleus sequencing identified a semaphorin 3C (SEMA3C)‐high stem‐like tumour subpopulation that drives gastric cancer peritoneal metastasis through early B‐cell factor 2 (EBF2)‐mediated FGF7 expression and enhanced FGF7–FGFR2 signalling with endothelial cells. Targeting the FGF–FGFR pathway may provide a promising therapeutic strategy.
Yajing Zhou, Chao Dong, Weikang Li, Minghao Sun, Qingyu Xie, Lixing Gu, Pengbo Wang, Chengxiang Xu, Tianzhan Gao, Caixin Zhu, Kaipeng Duan, Jin Zhou, Dongbao Li   +12 more
wiley   +1 more source

Decoding full-length factor VIII through the structural and functional lens of its B domain. [PDF]

Blood Vessel Thromb Hemost
Ramaraje Urs SU, Pellequer JL, Teulon JM, Ma B, Ugurlar D, Gasper S, Pepanian A, Müller J, Imhof D, Singh S, Oldenburg J, Biswas A.   +11 more
europepmc   +1 more source

A single‐cell census of pulmonary endarterectomies tissue across different anatomical regions in chronic thromboembolic pulmonary hypertension

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This study provides the first intra‐individual, regional single‐cell comparison of main/lobar versus bifurcate pulmonary endarterectomy (PEA) specimens. It reveals distinct macrophage polarisation, divergent T‐cell compositions and pronounced smooth muscle cell (SMC)‐to‐myofibroblast transition in the bifurcate region. These findings highlight regional
Rui Zhang, Yunlong Zhang, Huiting Li, Jing Zhang, Shou Han, Xinbo Cheng, Qinhua Zhao, Jing He, Cijun Luo, Hongling Qiu, Jianfeng Zhang, Sugang Gong, Lan Wang   +12 more
wiley   +1 more source