Results 31 to 40 of about 61,670 (295)

Enhanced VWF biosynthesis and elevated plasma VWF due to a natural variant in the murine Vwf gene

Blood, 2006
Abstract Both genetic and environmental influences contribute to the wide variation in plasma von Willebrand factor (VWF) levels observed in humans. Inbred mouse strains also have highly variable plasma VWF levels, providing a convenient model in which to study genetic modifiers of VWF.
Heidi L, Lemmerhirt, Jordan A, Shavit, Gallia G, Levy, Suzanne M, Cole, Jeffrey C, Long, David, Ginsburg   +5 more
openaire   +3 more sources

Viral inactivation in von Willebrand factor preparations via UVC irradiation: an experimental approach

Zhongguo shuxue zazhi
[Objective] To evaluate the efficacy of ultraviolet-C (UVC) irradiation in inactivating porcine parvovirus (PPV), encephalomyocarditis virus (EMCV), pseudorabies virus (PRV) and vesicular stomatitis virus (VSV) within von Willebrand factor (vWF ...
ZHANG Yalu, MA Jie, ZHANG Rong, YANG Chunhui   +3 more
doaj   +1 more source

Diagnostic Value of Measuring Platelet Von Willebrand Factor in Von Willebrand Disease. [PDF]

PLoS ONE, 2016
Von Willebrand disease (VWD) may be caused by an impaired von Willebrand factor (VWF) synthesis, its increased clearance or abnormal function, or combinations of these factors.
Alessandra Casonato, Maria Grazia Cattini, Viviana Daidone, Elena Pontara, Antonella Bertomoro, Paolo Prandoni   +5 more
doaj   +1 more source

ADAMTS-13 proteolyzed by thrombin has reduced affinity for von Willebrand factor (VWF)

, 2011
(A) 6 n ADAMTS-13, 60 n thrombin-cleaved ADAMTS-13 (ADAMTS-13/FIIa) or 60 n thrombin-cleaved ADAMTS-13/6 n ADAMTS-13 (10:1 mix) was incubated with 10 n purified plasma-derived VWF in the presence of 1.5 urea and 5 m BaCl.
C K N K CHION (48919), S ZANARDELLI (48920), J T B CRAWLEY (48922), J K LAM (48918), D A LANE (48921)   +4 more
core   +1 more source

Complex changes in von Willebrand factor-associated parameters are acquired during uncomplicated pregnancy. [PDF]

PLoS ONE, 2014
BACKGROUND:The coagulation protein von Willebrand Factor (VWF) is known to be elevated in pregnancy. However, the timing and nature of changes in VWF and associated parameters throughout pregnancy are not well understood.
Danielle N Drury-Stewart, Kerry W Lannert, Dominic W Chung, Gayle T Teramura, James C Zimring, Barbara A Konkle, Hilary S Gammill, Jill M Johnsen   +7 more
doaj   +1 more source

Clinical phenotype and pathophysiological mechanisms underlying qualitative low VWF [PDF]

Previous reports have highlighted that some patients with low von Willebrand factor (VWF) with significant bleeding were diagnosed based on an isolated but persistent reduction in plasma VWF activity levels in the 30 to 50 IU/dL range. These patients had
Roger Preston (7896068), Dearbhla Doherty (10046030), Anne-Marije Hulshof (18421287), Michelle Lavin (7895933), Ferdows Atiq (9906154), James O'Donnell (7895615)   +5 more
core   +4 more sources

ADAMTS13 Deficiency Worsens Colitis and Exogenous ADAMTS13 Administration Decreases Colitis Severity in Mice

TH Open, 2017
Background Inflammatory bowel disease (IBD) affects 1.6 million people in the United States. IBD is associated with an increased risk of thrombosis, which rises with disease activity.
Naamah L. Zitomersky, Melanie Demers, Kimberly Martinod, Maureen Gallant, Stephen M. Cifuni, Amlan Biswas, Scott Snapper, Denisa D. Wagner   +7 more
doaj   +1 more source

A conformation-sensitive monoclonal antibody against the A2 domain of von Willebrand factor reduces its proteolysis by ADAMTS13. [PDF]

PLoS ONE, 2011
The size of von Willebrand factor (VWF), controlled by ADAMTS13-dependent proteolysis, is associated with its hemostatic activity. Many factors regulate ADAMTS13-dependent VWF proteolysis through their interaction with VWF.
Jingyu Zhang, Zhenni Ma, Ningzheng Dong, Fang Liu, Jian Su, Yiming Zhao, Fei Shen, Anyou Wang, Changgeng Ruan   +8 more
doaj   +1 more source

Frequency weightings of hand-transmitted vibration for predicting vibration-induced white finger

Scandinavian Journal of Work, Environment & Health, 2011
OBJECTIVE: The aim of this study was to investigate the performance of four frequency weightings for hand-transmitted vibration to predict the incidence of vibration-induced white finger (VWF).
Massimo Bovenzi, Iole Pinto, Francesco Picciolo, Marcella Mauro, Federico Ronchese   +4 more
doaj   +1 more source

Comparative analysis of TRPM8 gene and COPD markers expression in rat lungs following exposure to cigarette smoke and tobacco aerosol

Acta Biomedica Scientifica
Background. Chronic Obstructive Pulmonary Disease (COPD) remains a global medical and social problem. The ion channel TRPM8, a cold receptor, is known to be involved in the pathogenesis of the disease.
P. D. Timkin, M. A. Kiselev, D. A. Shapovalova, D. E. Naumov, P. M. Linskaya, E. A. Borodin   +5 more
doaj   +1 more source