Results 121 to 130 of about 56,101 (281)

IL-6 Released from Hepatic Stellate Cells Promotes Glycolysis and Migration of HCC Through the JAK1/vWF/TGFB1 Axis

Journal of Hepatocellular Carcinoma
Yifei Zhu,1,* Jiayi Gu,1,* Yuxin Lu,1 Qianying Tao,1 Xinliang Cao,1 Yanqing Zhu,1 Mu-qing Yang,2 Xin Liang1 1Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of ...
Zhu Y, Gu J, Lu Y, Tao Q, Cao X, Zhu Y, Yang MQ, Liang X   +7 more
doaj  

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, EarlyView.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source

Biomarkers of Prothrombotic State and Risk Assessment of Exacerbations in Patients with Chronic Obstructive Pulmonary Disease

International Journal of COPD
Yan Jin,1,2,* Ke Zhu,1,* Shiyu Wu,1 Shiyi He,1 Chao Cao1 1Department of Respiratory and Critical Medicine, Key Laboratory of Respiratory Disease of Ningbo, The First Affiliated Hospital of Ningbo University, Ningbo, People’s Republic of China ...
Jin Y, Zhu K, Wu S, He S, Cao C
doaj  

Increased VWF-platelet binding and plasma VWF:Ag and active VWF levels in dengue patients.

, 2019
(A) Platelet-VWF binding measured by flow cytometry in unstimulated samples (line is geometric mean with 95% confidence interval) and (B) after ex vivo stimulation with increasing concentrations of ristocetin in participants with acute dengue and healthy
Silvita Fitri Riswari (476299), Quirijn de Mast (167198), Gloria S. R. Utari (6439901), Nur Farhanah (6439904), Gijs J. Overheul (142176), Dirk J. Lefeber (190780), Bachti Alisjahbana (270243), Rolf T. Urbanus (502328), Vesla Kullaya (6439895), Rahajeng N. Tunjungputri (4451650), Philip. G. de Groot (6439907), M. Hussein Gasem (263447), Ronald P. van Rij (142192), Fadel M. Garishah (6439898), Andre van der Ven (103962)   +14 more
core   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Development of mass spectrometry methods for the identification and quantification of pro-thrombotic oxidative modifications of von Willebrand factor

reservedIl fattore di von Willebrand (vWF) è una proteina plasmatica multimerica ad alto peso molecolare essenziale per l’emostasi primaria. I suoi multimeri ultra-large sono particolarmente trombogenici.
REGINATO, DENISE
core  

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

The relationships between disseminated intravascular coagulation and time series change of Von Willebrand factor in patients with out-of-hospital cardiac arrest: a retrospective observational study

Thrombosis Journal
Background Out-of-hospital cardiac arrest (OHCA) is frequently complicated by disseminated intravascular coagulation (DIC), which worsens outcomes. Von Willebrand factor (VWF) is central to haemostasis, and its multimeric size and activity are regulated ...
Yuki Itagaki, Yuki Chiba, Misako Suzuki, Mariko Hayamizu, Hisanori Horiuchi, Mineji Hayakawa   +5 more
doaj   +1 more source

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

British Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu, Da‐Hao Mai, Xing‐Ming Zhong, Li‐Ting Huang, Lan‐Ting Fu, He‐Cai Wang, Ke Wang, Hai‐Yan Li, Qiu‐He Chen, Yang Chen   +9 more
wiley   +1 more source

Enhanced VWF biosynthesis and elevated plasma VWF due to a natural variant in the murine Vwf gene

Both genetic and environmental influences contribute to the wide variation in plasma von Willebrand factor (VWF) levels observed in humans. Inbred mouse strains also have highly variable plasma VWF levels, providing a convenient model in which to study ...
Lemmerhirt, Heidi L.
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