Results 171 to 180 of about 17,893 (237)

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2568-2574, November 2026.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

Supplementing With the Vitamin A Metabolite Retinoic Acid Can Alleviate Negative Affective States Caused by SPI1‐Induced Immune and Metabolic Dysfunctions Following Intestinal Barrier Impairment

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Ulcerative colitis (UC) and depression (DP) are significant comorbidities in epidemiological research. However, the mechanisms underlying UC‐induced DP remain poorly understood. Myeloid differentiation and retinoic acid metabolic dysregulation are implicated in both conditions, yet their interconnection in the context of comorbidity is unclear.
Yang Feng, Pai Xie, Ni‐ren Li, Yi‐xuan Zeng, Bing‐ying Deng, Yu‐feng Gu, Si‐fan Lu, Yi Liu   +7 more
wiley   +1 more source

NLRP3+ Macrophages: Central Inflammatory Nodes of Abdominal Aortic Aneurysm and Potential Cellular Target of Omega‐3 Polyunsaturated Fatty Acids

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
We integrated three human aortic scRNA‐seq datasets to build an AAA cellular atlas and identified two key macrophage subsets. Homeostatic FOLR2+ macrophages are depleted in AAA, while NLRP3+ macrophages emerge as the core of inflammatory networks. In vitro, inflammatory stimuli induce pathological macrophage phenotypes.
Yuqi Wang, Hongrui Pan, Hechen Rong, Yu Zeng, Yinghong Li, Xiang Li, Zhian Liang, Jiaxin Wang, Lijian Fang, Peng Li, Xiangchen Dai   +10 more
wiley   +1 more source

Exosomal circ_0000387 Is Associated With Ovarian Cancer Metastatic Regulation Through IGF2BP3‐Related Signalling and Endothelial VWF Responses

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
In SKOV3 cells, circ_0000387 interacts with IGF2BP3 and is linked to AKT activation, AMPK inhibition, and increased YAP activity. Circ_0000387‐enriched exosomes increase endothelial VWF secretion in HUVECs, with reciprocal AKT/AMPK/YAP changes. In vivo, this exosome–VWF axis is associated with reduced peritoneal nodules, ascites, and SKOV3 invasion ...
Yulian Xie, Peijun Shen, Hailin Chen, Qianqian Shen, Xiaoxia Tong   +4 more
wiley   +1 more source

Neutrophil Extracellular Traps: From Mechanistic Insights to Therapeutic Targeting

MedComm, Volume 7, Issue 11, November 2026.
Neutrophil extracellular traps act as multimodal signal processors in cancer via three mechanisms: biomechanical scaffolds activating integrin–FAK signaling and excluding immune cells; immunometabolic hubs driving glycolysis and immunosuppression; and signal‐integration platforms synergistically activating oncogenic pathways.
Hongjie Fan, Yurui Tong, Bufu Tang, Jihong Hu, Xuefeng Kan, Bin Liang   +5 more
wiley   +1 more source

Adipose‐Derived Mesenchymal Stem Cells: Isolation, Origin, Phenotype Applications, and Challenges

MedComm, Volume 7, Issue 11, November 2026.
Bridging basic biology to clinical translation, this review systematically explores the in vivo origins and evolving isolation techniques of AD‐MSCs. We dissect their diverse phenotype applications orchestrated by immunometabolic reprogramming, mitochondrial transfer, and extracellular vesicles.
Ziyang Liu, Guangming Tu, Chao Wang, Hongyan Zhao, Ziyi Wu, Wei Li, Li Chen, Bailin Niu   +7 more
wiley   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, Volume 40, Issue 11, Page 6069-6093, November 2026.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, Volume 40, Issue 11, Page 6130-6153, November 2026.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Integrative Genetic and Single‐Cell Analysis Reveals Macrophages as Key Mediators Linking Aging and Osteoporosis

Aging Cell, Volume 25, Issue 11, November 2026.
This study reveals a bidirectional link between aging and osteoporosis. Integrating multi‐omics datasets, we identify macrophages as the pivotal cell type mediating this association. Furthermore, we uncover TGFB1 and the novel gene HNRNPUL1 as key regulators, offering promising therapeutic targets for age‐related bone loss.ABSTRACTOsteoporosis is a ...
Xin Li, Meng‐Yuan Yang, Si‐Rui Gai, Peng Wei, Zeng‐Hui Gu, Ming‐Yu Han, Yue‐Zhou Wu, Jia‐Sheng Yu, Wang‐Jun Chen, Zheng‐Rui Liao, Jia‐Xuan Gu, Jia‐Dong Zhong, Pian‐Pian Zhao, Ke Zhu, Ching‐Lung Cheung, David Karasik, Hou‐Feng Zheng   +16 more
wiley   +1 more source

LAMC2+ Epithelial Cells Drive Bladder Cancer Progression and Predict Immunotherapy Response via SERPINB3/STAT3/CD44 Axis

Cancer Science, Volume 117, Issue 11, Page 3071-3085, November 2026.
This study identified LAMC2+ epithelial cells through single‐cell sequencing and found that high expression of LAMC2 is associated with the malignant progression of bladder cancer. HdWGCNA and transcriptome sequencing revealed the SerpinB3/STAT3/CD44 axis. Diosmetin was selected as a potential LAMC2 inhibitor.
Yutong Chen, Yunzhong Jiang, Zezhong Yang, Minxuan Jing, Wentai Wu, Jiale He, Lu Wang, Minghai Ma, Yaodong Zhang, Min Wang, Jianpeng Li, Yuanchun Pu, Bingliang He, Yanjia Liu, Kaibo Mi, Hang Liu, Mengzhao Zhang, Jinhai Fan   +17 more
wiley   +1 more source