Results 11 to 20 of about 60,736 (289)

VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease [PDF]

Blood, 2013
Key Points VWFpp/VWF:Ag and FVIII:C/VWF:Ag ratios define the pathophysiological mechanisms that play a role in VWD and various VWF mutations. A high VWFpp/VWF:Ag ratio indicates increased clearance of VWF and a high FVIII:C/VWF:Ag ratio decreased synthesis of VWF.
J. Eikenboom, A.B. Federici, R. J. Dirven, G. Castaman, F. Rodeghiero, U. Budde, R. Schneppenheim, J. Batlle, M. T. Canciani, J. Goudemand, I. Peake, A. Goodeve   +11 more
core   +5 more sources

The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance [PDF]

Blood Advances, 2018
: Plasma levels of von Willebrand factor (VWF) vary considerably in the general population and this variation has been linked to several genetic and environmental factors. Genetic factors include 2 common single nucleotide variants (SNVs) located in VWF,
Ahmad H. Mufti, Kenichi Ogiwara, Laura L. Swystun, Jeroen C.J. Eikenboom, Ulrich Budde, Wilma M. Hopman, Christer Halldén, Jenny Goudemand, Ian R. Peake, Anne C. Goodeve, David Lillicrap, Daniel J. Hampshire   +11 more
doaj   +2 more sources

Sequence Alignment between vWF and Peptides Inhibiting the vWF-collagen Interaction Does not Result in the Identification of a Collagen-binding Site in vWF

Thrombosis and Haemostasis, 2000
SummaryWe previously found that two peptides (N- and Q-peptide) selected by phage display for binding to an anti-vWF antibody, were able to inhibit vWF-binding to collagen (1). The sequence of those peptides could be aligned with the sequence in vWF at position 1129-1136 just outside the A3-domain.
Vanhoorelbeke, K., van der Plas, R.M., Vandecasteele, G., Vauterin, S., Huizinga, E.G., Sixma, J.J., Deckmijn, H.   +6 more
openaire   +4 more sources

CURRENT KNOWLEDGE ON THE PATHOGENIC MECHANISMS OF HENOCH-SCHOENLEIN PURPURA IN CHILDREN [PDF]

Trakia Journal of Sciences, 2021
The Schӧnlein-Henoch vasculitis is an IgA-mediated inflammation of small vessels. The main clinical manifestation is palpable purpura without thrombocytopenia, manifested by bilateral symmetrical distribution on both lower limbs, abdominal pain, often ...
A.Vasileva, Iv. Chakarov, P. Chakarova
doaj   +1 more source

Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance [PDF]

, 2023
Increased von Willebrand factor (VWF) clearance plays a key role in the pathogenesis of type 1 and type 2 von Willebrand disease (VWD). However, the pathological mechanisms involved in patients with mild to moderate reductions in plasma VWF:Ag (range, 30-
Dearbhla Doherty (10046030), Pamela A Christopherson (15330705), Jorge Di Paola (15410202), Sandra L Haberichter (12654028), Kevin Ryan (356118), Jamie O'Sullivan (7895630), Zimmerman Program Investigations (17615819), Michelle Lavin (7895933), Niamh M O'Connell (11596417), James O'Donnell (7895615), Paula D James (10685405), Mary Byrne (4321339), Margaret Nolan (7948622)   +12 more
core   +5 more sources

Molecular Mechanisms of vWF Secretion [PDF]

, 2014
von Willebrand factor (vWF) secreted by endothelial cells (EC) is essential for hemostasis and thrombosis. However the molecular mechanism of vWF secretion is poorly understood.
Luiza Rusu (7973144)
core   +6 more sources

Prognostic value of von Willebrand factor in clinical practice

Акушерство, гинекология и репродукция, 2022
The von Willebrand factor (vWF) is a multimeric plasma glycoprotein, which quantification has important prognostic value. The current literature review demonstrates a relationship between the disease severity and vWF level.
K. N. Grigoreva, V. O. Bitsadze, J. Kh. Khizroeva, V. I. Tsibizova, M. V. Tretyakova, D. V. Blinov, L. L. Pankratyeva, N. R. Gashimova, F. E. Yakubova, A. S. Antonova, J.-C. Gris, I. Elalamy, A. D. Makatsariya   +12 more
doaj   +1 more source

Immunothrombosis in cancer patients: contribution of neutrophil extracellular traps, ADAMTS-13 and von Willebrand factor

Акушерство, гинекология и репродукция, 2023
Introduction. Neutrophil extracellular traps (NETs) and von Willebrand factor (vWF) are integral players in thrombosis and inflammation in cancer patients. It has been increasingly evident that an active interplay exists between NETs and vWF.
E. V. Slukhanchuk, V. O. Bitsadze, A. G. Solopova, J. Kh. Khizroeva, V. I. Tsibizova, J.-K. Gris, I. Elalamy, D. V. Shcherbakov, L. L. Pankratyeva, L. A. Ashrafyan, A. D. Makatsariya   +10 more
doaj   +1 more source

Neonatal thrombosis: risk factors and principles of prophylaxis

Акушерство, гинекология и репродукция, 2021
Data analysis on the pathogenesis and risk factors of neonatal thrombosis was carried out. The main risk factor of any neonatal thrombosis is central catheter installment, but other maternal, fetal and neonatal factors should be taken into consideration.
A. V. Vorobev, V. O. Bitsadze, J. Kh. Khizroeva, S. A. Potapkina, N. A. Makatsariya, G. Rizzo, G. C. Di Renzo, D. V. Blinov, L. L. Pankratyeva, V. I. Tsibizova   +9 more
doaj   +1 more source

Pathogenetic and prognostic significance of inflammation and altered ADAMTS-13/vWF axis in patients with severe COVID-19

Акушерство, гинекология и репродукция, 2022
Introduction. Currently, endothelial dysfunction caused by inflammation and immunothrombosisis considered as one of the crucial mechanisms in developing the SARS-CoV-2 virus-mediated coronavirus disease 2019 (COVID-19). A mass endothelial damage followed
V. O. Bitsadze, J. Kh. Khizroeva, J.-Ch. Gris, S. Schulman, A. S. Shkoda, M. V. Tretyakova, N. A. Makatsariya, E. V. Slukhanchuk, L. L. Pankratyeva, M. I. Petrovskiy, I. V. Mashechkin, D. V. Blinov, V. I. Tsibizova, Z. K. Gadaeva, S. S. Panshin, N. V. Samburova, A. D. Makatsariya   +16 more
doaj   +1 more source