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DNA methylation is associated with von Willebrand factor and coagulation factor VIII plasma levels: the atherosclerosis risk in communities study. [PDF]
Clin EpigeneticsHahn J +6 more
europepmc +1 more source
Uptake of vWF–Anti-vWF Complexes by Platelets in Suspension [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 1996 Efforts to identify the translocation of glycoprotein (GP) Ib/IX receptors, either bound to von Willebrand factor (vWF) or not, from exposed surfaces to interior membranes of thrombin-activated platelets in suspension have been unsuccessful. To observe vWF uptake by platelets, we added an anti-vWF antibody and staphylococcal protein A–gold (to act as a
Gines Escolar +2 more
exaly +4 more sources
Sequence Alignment between vWF and Peptides Inhibiting the vWF-collagen Interaction Does not Result in the Identification of a Collagen-binding Site in vWF [PDF]
Thrombosis and Haemostasis, 2000 SummaryWe previously found that two peptides (N- and Q-peptide) selected by phage display for binding to an anti-vWF antibody, were able to inhibit vWF-binding to collagen (1). The sequence of those peptides could be aligned with the sequence in vWF at position 1129-1136 just outside the A3-domain.
Hans Deckmyn, J J Sixma
exaly +5 more sources
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Critical independent regions in the VWF propeptide and mature VWF that enable normal VWF storage
Blood, 2003Von Willebrand factor (VWF) is synthesized in endothelial cells, where it is stored in Weibel-Palade bodies. Administration of 1-desamino-8-D-arginine-vasopressin (DDAVP) to patients with type 1 von Willebrand disease and to healthy individuals causes a rapid increase in plasma VWF levels.
Sandra L, Haberichter +2 more
openaire +2 more sources
[The Effect of VWF Propeptide on VWF Mutant in D1 Domain].
Zhongguo shi yan xue ye xue za zhi, 2022To investigate whether co-transfection of wild-type VWFpp with VWF mutant in D1 region is able to correct VWF defects in biosynthesis and secretion.Four VWF mutant plasmids were single transfected into HEK 293 cells, or co-transfected into HEK 293 cells with the wild type VWFpp plasmids.
Xiu-Qun, Yu +6 more
openaire +1 more source