Results 171 to 180 of about 56,156 (204)

The smaller, the better: VWF in stroke

Blood, 2010
In this issue of Blood , Fujioka and colleagues demonstrate that the von Willebrand factor–cleaving protease ADAMTS13 limits brain infarction in a murine model of ischemic stroke.[1][1] Platelet aggregation at sites of vascular injury is essential for normal hemostasis but also causes ...
Bernhard, Nieswandt, Guido, Stoll
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The role of VWF in the immunogenicity of FVIII

Thrombosis Research, 2008
Up to 33% of patients with severe haemophilia A develop inhibitory antibodies to factor VIM (FVIII) that can significantly impair treatment with FVIII. The plasma protein von Willebrand factor (VWF) binds to FVIII and is known to be important for the functioning of FVIII.
Sébastien, Lacroix-Desmazes, Yohann, Repessé, Srinivas V, Kaveri, Suryasarathi, Dasgupta   +3 more
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Oxidative stress on VWF proteolysis

Blood, 2010
In this issue of Blood , Chen and colleagues demonstrate that the rate of cleaving VWF by ADAMTS13 is significantly slowed when the residue Met1606 in the VWF A2 domain is oxidized.[1][1] The finding adds a new dimension to the complexity of regulating VWF cleavage and links the rate of ...
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Sugar targets VWF for the chop

Blood, 2010
In this issue of Blood , McGrath et al provide new insights into the influence of glycosylation on VWF proteolysis by ADAMTS13.[1][1] Von Willebrand factor (VWF) is synthesized in vascular endothelial cells and megakaryocytes and undergoes extensive processing prior to secretion.
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Alanine Scanning Mutagenesis of the VWF-A1 Flanking Regions of VWF and the Impact on Ristocetin-induced VWF Interaction with Platelets

Blood, 2013
Abstract Von Willebrand disease is a bleeding disorder with reduced or abnormal function of VWF. While VWF has at least three functions (binding to FVIII, platelet GPIb, and collagen), the function of VWF has been quantified primarily using techniques in which ristocetin promotes the binding of VWF to platelet GPIb. It is recognized that
Robert R. Montgomery, Sandra L. Haberichter, Matt Hille, Patti Morateck, J. Paul Scott, Veronica H. Flood   +5 more
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Evaluation of Monoclonal Antibodies to vWf Antigen for Use in Autoradiographing vWf Multimer Analysis

Thrombosis and Haemostasis, 1987
SummaryNine monoclonal antibodies (MAb, coded ESvWF 1-5, 7-10) to human von Willebrand’s factor (vWf) have been studied for their labelling characteristics with 125I and their ability to demonstrate vWf multimers by autoradiography after discontinuous SDS electrophoresis on agarose and agarose/acrylamide gels in plasma from normal and von Willebrand’s ...
M S, Enayat, F G, Hill, W, Robinson, C V, Prowse, V S, Hornsey   +4 more
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STA LIA vWF

Hämostaseologie, 1996
ZusammenfassungDie immunologische Bestimmung der von-Willebrand-Faktor-Konzentration ist ein wichtiger Baustein in der Strategie zur Diagnostik des von-Willebrand-Syn-droms. Mit dem hier vorgestellten Test, STA LIA vWF (Boehringer Mannheim GmbH) kann diese Bestimmung in der Routineanalytik innerhalb von 10 Minuten an den Gerinnungssystemen STA und STA ...
Ute Reimann, K.-E. Stötzer
openaire   +1 more source

vWf

2006
  +4 more sources

COVID-19 microthrombosis: unusually large VWF multimers are a platform for activation of the alternative complement pathway under cytokine storm

International Journal of Hematology, 2022
Yoshihiro Fujimura, Linda Holland, Fujimura Yoshihiro   +2 more
exaly  

VWF

2011
openaire   +2 more sources