Results 301 to 310 of about 81,482 (329)

Force sensing by Piezo1 regulates endothelial secretory granule exocytosis

El-Mansi S, Al-Saegh M, Rolas L, Golding M, Voisin M, Nourshargh S, Nightingale TD.   +6 more
europepmc   +1 more source

Von Willebrand Factor Deficiency Impairs Vascular Morphogenesis via Angiopoietin-2: Relevance for Gut Angiodysplasia

Constantinescu-Bercu A, Smith KE, Wong SY, Ballerini M, Nastro A, Wiggins BG, Pirri D, Li A, Evers J, Tsiamita O, Dibble M, Pericleous C, Paschalaki K, Birdsey GM, Laffan MA, Sivapalaratnam S, Rasponi M, Randi AM.   +17 more
europepmc   +1 more source

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Critical independent regions in the VWF propeptide and mature VWF that enable normal VWF storage

Blood, 2003
Von Willebrand factor (VWF) is synthesized in endothelial cells, where it is stored in Weibel-Palade bodies. Administration of 1-desamino-8-D-arginine-vasopressin (DDAVP) to patients with type 1 von Willebrand disease and to healthy individuals causes a rapid increase in plasma VWF levels.
Sandra L, Haberichter, Paula, Jacobi, Robert R, Montgomery   +2 more
openaire   +2 more sources

Uptake of vWF–Anti-vWF Complexes by Platelets in Suspension

Arteriosclerosis, Thrombosis, and Vascular Biology, 1996
Efforts to identify the translocation of glycoprotein (GP) Ib/IX receptors, either bound to von Willebrand factor (vWF) or not, from exposed surfaces to interior membranes of thrombin-activated platelets in suspension have been unsuccessful. To observe vWF uptake by platelets, we added an anti-vWF antibody and staphylococcal protein A–gold (to act as a
J G, White, M D, Krumwiede, D J, Cocking-Johnson, G, Escolar   +3 more
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STA LIA vWF

Hämostaseologie, 1996
ZusammenfassungDie immunologische Bestimmung der von-Willebrand-Faktor-Konzentration ist ein wichtiger Baustein in der Strategie zur Diagnostik des von-Willebrand-Syn-droms. Mit dem hier vorgestellten Test, STA LIA vWF (Boehringer Mannheim GmbH) kann diese Bestimmung in der Routineanalytik innerhalb von 10 Minuten an den Gerinnungssystemen STA und STA ...
Ute Reimann, K.-E. Stötzer
openaire   +1 more source

[The Effect of VWF Propeptide on VWF Mutant in D1 Domain].

Zhongguo shi yan xue ye xue za zhi, 2022
To investigate whether co-transfection of wild-type VWFpp with VWF mutant in D1 region is able to correct VWF defects in biosynthesis and secretion.Four VWF mutant plasmids were single transfected into HEK 293 cells, or co-transfected into HEK 293 cells with the wild type VWFpp plasmids.
Xiu-Qun, Yu, Zhen-Ni, Ma, Jing, Ling, Yun-Xiao, Zhao, Jie, Yin, Zi-Qiang, Yu, Chang-Geng, Ruan   +6 more
openaire   +1 more source

Oxidative stress on VWF proteolysis

Blood, 2010
In this issue of Blood , Chen and colleagues demonstrate that the rate of cleaving VWF by ADAMTS13 is significantly slowed when the residue Met1606 in the VWF A2 domain is oxidized.[1][1] The finding adds a new dimension to the complexity of regulating VWF cleavage and links the rate of ...
openaire   +2 more sources

Evaluation of Monoclonal Antibodies to vWf Antigen for Use in Autoradiographing vWf Multimer Analysis

Thrombosis and Haemostasis, 1987
SummaryNine monoclonal antibodies (MAb, coded ESvWF 1-5, 7-10) to human von Willebrand’s factor (vWf) have been studied for their labelling characteristics with 125I and their ability to demonstrate vWf multimers by autoradiography after discontinuous SDS electrophoresis on agarose and agarose/acrylamide gels in plasma from normal and von Willebrand’s ...
M S, Enayat, F G, Hill, W, Robinson, C V, Prowse, V S, Hornsey   +4 more
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SHEARiO, fast lane to oxidized VWF

Blood, 2011
In this issue of Blood , Fu and coworkers show that shear stress–induced conformational changes in VWF allow the exposure of otherwise buried methionine residues, thereby promoting their susceptibility to oxidation. 1 Methionine oxidation importantly alters the interaction between VWF and platelets and prevents degradation of the protein by ADAMTS13.
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