Results 251 to 260 of about 252,763 (309)

Programmed cell death regulates hematopoietic cell homeostasis under radiation conditions. [PDF]

Stem Cell Res Ther
Shu M, Zhang J, Peng Y, Li Z, Shu X, Wang J, Zeng H, Shao L.   +7 more
europepmc   +1 more source

Is Nav1.8-specific inhibition the only path? Preferential Nav blockers offer a compelling alternative. [PDF]

Proc Natl Acad Sci U S A
Xiang B, Deng C, Yang H, Zhang W.
europepmc   +1 more source

Molecular and pharmacological evaluation of rare, cystic fibrosis-causing missense mutations of the CFTR channel. [PDF]

J Physiol
Závoti O, Csanády L.
europepmc   +1 more source

The local compactness of $vX$.

, 1974
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State-Dependent Inhibition of Nav1.8 Sodium Channels by VX-150 and VX-548

Molecular Pharmacology
Nav1.8 sodium channels (Nav1.8) are an attractive therapeutic target for pain because they are prominent in primary pain-sensing neurons with little expression in most other kinds of neurons. Recently, two Nav1.8-targeted compounds, VX-150 and VX-548, have shown efficacy in clinical trials for reducing pain.
Patric Vaelli, Akie Fujita, Sooyeon Jo, Han-Xiong Bear Zhang, Tomás Osorno, Xiao Ma, Bruce P. Bean   +6 more
openaire   +3 more sources

Topical VX-509 Attenuates Psoriatic Inflammation Through the STAT3/FABP5 Pathway in Keratinocytes.

Pharmacological Research, 2022
BACKGROUND Psoriasis is a chronic inflammatory disease, with lesions mainly manifesting as scaly erythematous plaques. The mild or moderate of psoriasis is the main type of patients in hospital, and topical application remains the preferred treatment ...
B. Yan, Panpan Liu, Xiaoqing Yi, Jie Li, Nian Liu, Wu Zhu, Y. Kuang, Xiang Chen, C. Peng   +8 more
semanticscholar   +1 more source