Results 261 to 270 of about 252,763 (309)
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The Journal of pharmacy and pharmacology, 2021
OBJECTIVE This study explores the potential role of a highly selective caspase-1 inhibitor, VX-765, on extracellular matrix (ECM) accumulation and inflammation in diabetic nephropathy (DN) and the underlying mechanisms.
Xiaokang Wang +6 more
semanticscholar +1 more source
OBJECTIVE This study explores the potential role of a highly selective caspase-1 inhibitor, VX-765, on extracellular matrix (ECM) accumulation and inflammation in diabetic nephropathy (DN) and the underlying mechanisms.
Xiaokang Wang +6 more
semanticscholar +1 more source
VX-548 in the treatment of acute pain.
Pain ManagementAcute pain management requires balancing analgesia with adverse effects risk. The voltage-gated sodium channel NaV1.8 plays an important role in pain physiology, and its inhibition was shown to have analgesic effects. VX-548 is a new oral NaV1.8-specific
Aaron Yik Hang Kong +2 more
semanticscholar +1 more source
Gender difference in the pharmacokinetics and metabolism of VX‐548 in rats
Biopharmaceutics & drug dispositionVX‐548 is a sodium channel blocker, which acts as an analgesic. This study aims to investigate the gender differences in the pharmacokinetics and metabolism of VX‐548 in rats.
Guilan Yu, Xueying Zhou
semanticscholar +1 more source
Analytical Chemistry, 2010
Room temperature rate constants and product ion branching ratios have been measured for the reactions of numerous positive and negative ions with VX chemical warfare agent surrogates representing the amine (triethylamine) and organophosphonate (diethyl methythiomethylphosphonate (DEMTMP)) portions of VX.
Anthony J, Midey +5 more
openaire +2 more sources
Room temperature rate constants and product ion branching ratios have been measured for the reactions of numerous positive and negative ions with VX chemical warfare agent surrogates representing the amine (triethylamine) and organophosphonate (diethyl methythiomethylphosphonate (DEMTMP)) portions of VX.
Anthony J, Midey +5 more
openaire +2 more sources
Analysis of Trace VX in Acidified VX Hydrolysate Samples
2009Abstract : The objective of this study was to modify and optimize US Army Element, Assembled Chemical Weapons Alternatives (USAE ACWA) method BGCAPP-204 (VX in Caustic Hydrolysate by Cool on-Column GC/MS) for analysis of ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (VX) in acidified VX hydrolysate matrices.
Yu-Chu Yang, Dennis K. Rohrbaugh
openaire +1 more source
In Analysis, 2020
A sensitive surface-enhanced Raman spectroscopy (SERS) substrate was developed to enable hand-held Raman spectrometers to detect gas-phase VX and HD. The substrate comprised Au nanoparticles modified onto quartz fibres. Limits of detection (LOD) of 0.008
V. Heleg-Shabtai +4 more
semanticscholar +1 more source
A sensitive surface-enhanced Raman spectroscopy (SERS) substrate was developed to enable hand-held Raman spectrometers to detect gas-phase VX and HD. The substrate comprised Au nanoparticles modified onto quartz fibres. Limits of detection (LOD) of 0.008
V. Heleg-Shabtai +4 more
semanticscholar +1 more source
Notfall & Rettungsmedizin, 2002
Lange Zeit war ein chemischer Kampfmittelangriff ein militarisches Szenario. Spatestens seit der Attacke mit Sarin auf die Tokioter U-Bahn im Jahre 1995 durch den Aum-Shinrikyo-Kult werden zivile Kampfstoffeinsatze in den Szenarien von vielen Katastrophenplanern mit einbezogen.
T. Bey, F. G. Walter
openaire +1 more source
Lange Zeit war ein chemischer Kampfmittelangriff ein militarisches Szenario. Spatestens seit der Attacke mit Sarin auf die Tokioter U-Bahn im Jahre 1995 durch den Aum-Shinrikyo-Kult werden zivile Kampfstoffeinsatze in den Szenarien von vielen Katastrophenplanern mit einbezogen.
T. Bey, F. G. Walter
openaire +1 more source
Chemical & Engineering News Archive, 2005
THE ARMY'S CONTROVERSIAL and problem-plagued plan to destroy VX nerve agent stored at Newport, Ind., just hit another snag: The waste by-product of VX neutralization is flammable. Under current plans, the Army would neutralize VX at Newport and transport the by-product, called hydrolysate, to a DuPont facility in New Jersey for secondary treatment and ...
openaire +1 more source
THE ARMY'S CONTROVERSIAL and problem-plagued plan to destroy VX nerve agent stored at Newport, Ind., just hit another snag: The waste by-product of VX neutralization is flammable. Under current plans, the Army would neutralize VX at Newport and transport the by-product, called hydrolysate, to a DuPont facility in New Jersey for secondary treatment and ...
openaire +1 more source
Main Group Chemistry, 2010
O-ethyl S-(2-diisopropylaminoethyl)phosphonothiolate (VX) is among the most toxic of chemical warfare agents. VX is an oily liquid that is relatively involatile and is slow to hydrolyze, and thus may persist for weeks or longer in the environment, creating long term contamination of the territory.
openaire +1 more source
O-ethyl S-(2-diisopropylaminoethyl)phosphonothiolate (VX) is among the most toxic of chemical warfare agents. VX is an oily liquid that is relatively involatile and is slow to hydrolyze, and thus may persist for weeks or longer in the environment, creating long term contamination of the territory.
openaire +1 more source
Degradation and Detection of the Nerve Agent VX by a Chromophore-Functionalized Zirconium MOF
Chemistry of Materials, 2019Nerve agents are among the most toxic substances known to man. Recent events in Syria, Malaysia, and the UK illustrate that the threat of these substances is real and actual.
M. D. de Koning +4 more
semanticscholar +1 more source