Results 211 to 220 of about 988,140 (311)

National and State Societal Costs of Schizophrenia in the US in 2024.

JAMA Psychiatry
Krasa HB, Baumgardner JR, Brewer IP, Chou JW, Flottemesch T, Markowitz JT, Williams C, Nagendra A.   +7 more
europepmc   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

Advanced Science, EarlyView.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin, Shulan Xiao, Krishna Jayant   +2 more
wiley   +1 more source

The Price of Dedication: An Analysis of Wage Trajectories in State and Local Public Health From 2017 to 2024. [PDF]

J Public Health Manag Pract
Singh S, Singh S, Gee M, Popalis M, Hare Bork R, Yeager VA.   +5 more
europepmc   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

Prices, availability, and affordability of selected medicines for asthma management in Nigeria: a nationwide study. [PDF]

BMC Health Serv Res
Amorha KC, Eze FN, Uzuh IF, Nwani SP, Iganga JC, Eze CE, Ifeanyi CR, Agubata AA, Ibenekwu CS, Aniebonam IC, Ani AC, Ezenwafor CC, Omene EC, Chukwuwa OM, Ezeala CP, Mbakamma CE, Nworah CR, Udoji MD, Ochie KM, Sabastine RN, Obi OC, Oparaocha RN, Okoye CR, Eze OP.   +23 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Digital Exclusion Among People Experiencing Homelessness and Residents of Urban Communities in Brazil: Cross-Sectional Study.

JMIR Public Health Surveill
Tártaro AF, Gomes D, Berra TZ, Tavares RBV, Alves YM, Ferezin LP, Ramos ACV, Zini N, Pelodan MEP, Popolin MAP, Arcêncio RA.   +10 more
europepmc   +1 more source

Trial-Based Costs for Interventions to Improve HPV Vaccine Uptake. [PDF]

JAMA Netw Open
Hung A, Finney Rutten LJ, Griffin JM, MacLaughlin KL, Jenkins G, Herrin J, Kong WY, Zhu X, Jacobson RM.   +8 more
europepmc   +1 more source