Results 131 to 140 of about 8,636,999 (167)

Thrombolytic Therapy in Wake-Up Stroke Patients

Clinical Neuropharmacology, 2017
Objective The aim of the study is to review existing and ongoing trial data on wake-up stroke (WUS) patients for thrombolytic therapy. Methods A literature search was conducted in PubMed (conception–October 2016) using the terms wake-up stroke, acute ischemic stroke, wake-up ...
Gretchen M, Stern, Nicholas, Van Hise, Lindsay M, Urben, Matthew J, Korobey, Jamie M, Pitlick, Andrew J, Crannage   +5 more
openaire   +3 more sources

Tenecteplase in wake-up ischemic stroke trial: Protocol for a randomized-controlled trial [PDF]

International Journal of Stroke, 2021
BACKGROUND: Patients with wake-up ischemic stroke who have evidence of salvageable tissue on advanced imaging can benefit from intravenous thrombolysis. It is not known whether patients who do not fulfil such imaging criteria might benefit from treatment,
Dalius Jatuzis, Ellisiv Mathiesen, Mirza Jusufovic   +2 more
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Management of a wake-up stroke

Practical Neurology, 2019
Current national guidelines advocate intravenous thrombolysis to treat patients with acute ischaemic stroke presenting within 4.5 hours from symptom onset, and thrombectomy for patients with anterior circulation ischaemic stroke from large vessel occlusion presenting within 6 hours from onset.
Xuya Huang, Vafa Alakbarzade, Nader Khandanpour, Anthony C Pereira   +3 more
openaire   +2 more sources

Wake-Up Stroke

Topics in Magnetic Resonance Imaging, 2017
Patients with wake-up strokes account for approximately 1 in 5 individuals presenting with an acute ischemic stroke. However, they are commonly excluded from acute stroke treatment. This article reviews the current understanding of wake-up strokes. A comparison of wake-up and awake-onset strokes demonstrated that they are physiologically, clinically ...
Jenny P, Tsai, Gregory W, Albers
openaire   +2 more sources

Wake-Up or Unclear-Onset Strokes: Are they Waking up to the World of Thrombolysis Therapy?

International Journal of Stroke, 2012
Wake-up or unclear-onset strokes occur in up to one-fourth of patients with ischemic stroke. Although stroke severity and clinical outcomes appear to be poorer in wake-up strokes than nonwake-up strokes, many patients with wake-up strokes do not receive thrombolytic therapy because stroke onset time cannot be determined.
Dong-Wha, Kang, Joo Y, Kwon, Sun U, Kwon, Jong S, Kim   +3 more
openaire   +2 more sources

Smart Wake-up Stroke Alert System

2020 IEEE REGION 10 CONFERENCE (TENCON), 2020
Wake-up stroke refers to a kind of ischemic stroke where a person wakes up with symptoms of stroke that are not present before going to sleep. These symptoms may include muscle weakness, drowsiness, walking difficulties, face drooping among others. Risk factors for ischemic strokes are Diabetes, Hypertension, Obesity, age, tobacco use, etc.
Lakshmi Boppana, Bharat Kumar Kuppuru, Krishna Karthik Nerella, Sharmila Kovvada   +3 more
openaire   +1 more source

Abstract T P168: A Wake-up Call for Wake-up Strokes

Stroke, 2015
INTRODUCTION: Studies suggest 8%-28% of ischemic strokes present as wake-up strokes (WUS). The unknown time of symptom onset precludes these patients from approved treatments for acute ischemic stroke, but a substantial proportion of patients may be deemed candidates for treatment if other factors are considered.
Josephine F Huang, Jennifer E Fugate, Alejandro A Rabinstein   +2 more
openaire   +1 more source

Abstract TP75: Waking Up To A New Wake-Up Stroke Protocol Is Feasible And Safe

Stroke, 2023
Introduction: Up to 25% of strokes are recognized upon awakening. Recent studies have demonstrated that a “tissue clock” rather than a time clock can be used to identify patients who may benefit from intravenous thrombolytics (IVT) beyond 4.5 hours from last known well (LKW).
Maheen Rana, Tina M Burton, Mahesh Jayaraman, Daniel Mandel, Liqi Shu, Eric D Goldstein, Narendra Kala, Christoph Stretz, Elizabeth Perelstein, Sleiman El Jamal, Krisztina Moldovan, Jeffrey Rogg, Gaurav Jindal, Matthew Alvin, Jerrold Boxerman, Tracy Madsen, Rebecca Karb, David Fussell-Louie, Andrew Buksar, Melissa Harmon, Karen L Furie, Shadi Yaghi   +21 more
openaire   +1 more source

Treating Wake-Up Stroke Patients

Current Radiology Reports, 2013
In 20–25 % of stroke patients, stroke occurs during sleep. Due to the missing information on time of symptom onset, these patients with “wake-up stroke” are excluded from treatment with intravenous thrombolysis based on licensing criteria. Within the past years, however, new approaches to guide treatment in wake-up stroke patients have been suggested ...
Götz Thomalla, Jens Fiehler
openaire   +1 more source

Recanalisation therapies for wake-up stroke

Cochrane Database of Systematic Reviews, 2014
Background About one in five strokes occur during sleep (wake-up stroke). People with wake-up strokes have traditionally been considered ineligible for thrombolytic treatment because the time of stroke onset is unknown. However, some studies suggest that these people may benefit from recanalisation therapies.
Haakon Lindekleiv, Ellisiv B Mathiesen, Eivind Berge   +2 more
openaire   +1 more source