Results 41 to 50 of about 369,913 (319)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Daily Fluctuation of Orexin Neuron Activity and Wiring: The Challenge of “Chronoconnectivity”

Frontiers in Pharmacology, 2018
In the heterogeneous hub represented by the lateral hypothalamus, neurons containing the orexin/hypocretin peptides play a key role in vigilance state transitions and wakefulness stability, energy homeostasis, and other functions relevant for motivated ...
Idris A. Azeez, Federico Del Gallo, Luigia Cristino, Marina Bentivoglio, Marina Bentivoglio   +4 more
doaj   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

MultiModal Wireless Sensor Networks based on Wake-up Radio Receivers: An analytical Model for Energy Consumption

Revista Facultad de Ingeniería Universidad de Antioquia, 2019
Algunas técnicas sofisticadas de ahorro de energía se han venido empleando para lograr eficiencia energética en Redes Inalámbricas de Sensores (WSNs), tales como los protocolos de bajo ciclo de trabajo enmarcados en una arquitectura de único radio. Estos
Juan Aranda, Mario Schölzel, Diego Mendez, Henry Carrillo   +3 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Numerical Investigation of the Influence of the Wake of Wind Turbines with Different Scales Based on OpenFOAM

Applied Sciences, 2022
The wake of a wind turbine has an important influence on the output power of wind farms. Staggered height layout is an emerging method for the layout optimization of wind farms.
Wenxin Tian, Hao Tie, Shitang Ke, Jiawei Wan, Xiuyong Zhao, Yuze Zhao, Lidong Zhang, Sheng Wang   +7 more
doaj   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

Effects of Rotor-Rotor Interaction on the Wake Structure and Thrust Generation of a Quadrotor Unmanned Aerial Vehicle

IEEE Access, 2021
In this paper, the effects of rotor-rotor interaction on the wake structure and thrust generation of a quadrotor unmanned aerial vehicle (UAV) are experimentally investigated in the rotor tip Reynolds number range of 34000 – 54000. The interaction
Seungcheol Lee, Seokbong Chae, Seong Yong Woo, Jaesung Jang, Jooha Kim   +4 more
doaj   +1 more source

Modification of three-dimensional transition in the wake of a rotationally oscillating cylinder [PDF]

, 2010
A study of the flow past an oscillatory rotating cylinder has been conducted, where the frequency of oscillation has been matched to the natural frequency of the vortex street generated in the wake of a stationary cylinder, at Reynolds number 300.
Leontini, Justin S., Justin S. Leontini, Mark C. Thompson, Lo Jacono, David, Thompson, Mark C., John Sheridan, David Lo Jacono, Sheridan, John   +7 more
core   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source